Gene · 835
CASP2: caspase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CASP2: caspase 2. Genes, record 835. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/835
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P42575 | Caspase-2 | 452 | 17 | Ensembl, GeneID, HGNC |
Source UniProt
Patents81
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026031556 A | 2026-02-24 | 11 | P42575 | Espacenet |
| US 12539325 B2 | 2026-02-03 | 19 | P42575 | Espacenet |
| JP 2025183238 A | 2025-12-16 | 3 | P42575 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4854 | P42575 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16528 | P42575 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4854 | P42575 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 12250 | P42575 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 16528 | P42575 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 16528 | P42575 | Espacenet |
| US 12150938 B2 | 2024-11-26 | 18 | P42575 | Espacenet |
1 to 10 of 81
See all 81 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| EMRICASAN | CHEMBL197672 | Caspase inhibitor | INHIBITOR |
Source ChEMBL
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04803227 | EMRICASAN | PHASE1 | ClinicalTrials.gov | |
| NCT03205345 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02686762 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02230683 | EMRICASAN | PHASE2 | 2016-12-21 | ClinicalTrials.gov |
| NCT02230670 | EMRICASAN | PHASE2 | 2017-07-05 | ClinicalTrials.gov |
| NCT02138253 | EMRICASAN | PHASE2 | 2019-12-11 | ClinicalTrials.gov |
| NCT02077374 | EMRICASAN | PHASE2 | 2016-07-21 | ClinicalTrials.gov |
| NCT01937130 | EMRICASAN | PHASE2 | 2016-04-11 | ClinicalTrials.gov |
| NCT01912404 | EMRICASAN | PHASE2 | 2016-11-04 | ClinicalTrials.gov |
| NCT01653899 | EMRICASAN | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants2,142
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CASP2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 12 | 2025 |
| P01CA097132 | Sphingolipids in Cancer Biology and Therapy | 8 | 2025 |
| R01DK120714 | Control of Lipogenesis and Hepatic Steatosis by Caspase-2 | 6 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 5 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P50AA011999 | Southern California Research Center for ALPD and Cirrhosis | 5 | 2025 |
| R01GM135301 | A Non-Canonical IRAK1 Signaling Pathway Triggered by Ionizing Radiation | 5 | 2025 |
1 to 10 of 2,142Source NIH's project files
See all 2,142 nih grantsPapers3,745
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Methods to study PIDDosome and caspase-2 signalling. | Methods Cell Biol | 2026 | 42692556 | PubTator, text mining | PubMed |
| The truncated Tau fragment 315-441 produced by Caspase-2 translocates to the nucleus and alters the proteome of neuroblastoma cells. | Eur J Cell Biol | 2026 | 42659873 | PubTator, text mining | PubMed |
| Caspase-2 is involved in IFN-γ primed THP-1 derived macrophages cell death through regulating caspase-8 activation. | Hum Immunol | 2026 | 42632271 | PubTator, text mining | PubMed |
| A Distinct c-Raf-MEK1/2-p38 MAPK-Caspase Signaling Pathway Mediates TNF-α-Induced Rapid and Non-Lytic Neutrophil Extracellular Trap Formation in Human Neutrophil-Like Cells. | J Interferon Cytokine Res | 2026 | 42565367 | PubTator, text mining | PubMed |
| Apoptosis protein markers in comorbid type 2 diabetes mellitus and depression; relationships with cognitive performance, incident dementia, and white matter hyperintensities. | J Affect Disord | 2026 | 42556583 | PubTator, text mining | PubMed |
| S100A11 regulates hepatic cholesterol metabolism and promotes steatohepatitis via noncanonical SREBP2 signaling. | J Clin Invest | 2026 | 42550612 | PubTator, text mining | PubMed |
| Comprehensive Experimental and Computational Characterization of a Phenylacetamide-Based Molecule. | Biomed Res Int | 2026 | 42446101 | PubTator, text mining | PubMed |
| Correction: An unexpected role for caspase-2 in neuroblastoma. | Cell Death Dis | 2026 | 42414256 | PubTator, text mining | PubMed |
Intervening in p53-Induced Death Domain Protein 1 to Decrease Regulatory T Cell Recruitment Boosts the Effectiveness of Radiofrequency Ablation Combined With Anti-Programmed Cell Death Protein-1 Therapy in Hepatocellular Carcinoma. | Cell Mol Gastroenterol Hepatol | 2026 | 42398821 | PubTator, text mining | PubMed |
| Pulsed Electromagnetic Field Increases Doxorubicin-induced Mitotic Slippage in MDA-MB-231 Breast Cancer Cells. | Anticancer Res | 2026 | 42373288 | PubTator, text mining | PubMed |
1 to 10 of 3,745
See all 3,745 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/835
GET https://conductscience.org/api/genes/v1/835/patents?page=2