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Gene · 835

CASP2: caspase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CASP2: caspase 2. Genes, record 835. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/835

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Gene

Symbol
CASP2
HGNC
Name
caspase 2
HGNC
NCBI Gene ID
835
NCBI Gene
HGNC ID
HGNC:1503
HGNC
Ensembl
ENSG00000106144
NCBI Gene
Aliases
CASP-2, ICH1, MGC2181, MRT80, NEDD-2, NEDD2, PPP1R57
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P42575Caspase-245217Ensembl, GeneID, HGNC

Source UniProt

Patents81

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026031556 A2026-02-2411P42575Espacenet
US 12539325 B22026-02-0319P42575Espacenet
JP 2025183238 A2025-12-163P42575Espacenet
EP 4650780 A22025-11-194854P42575Espacenet
JP 2025147176 A2025-10-0616528P42575Espacenet
JP 2025517970 A2025-06-124854P42575Espacenet
JP 2025062604 A2025-04-1412250P42575Espacenet
JP 2025028160 A2025-02-2816528P42575Espacenet
KR 1020250010750 A2025-01-2116528P42575Espacenet
US 12150938 B22024-11-2618P42575Espacenet

1 to 10 of 81

See all 81 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
EMRICASANCHEMBL197672Caspase inhibitorINHIBITOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04803227EMRICASANPHASE1ClinicalTrials.gov
NCT03205345EMRICASANPHASE2ClinicalTrials.gov
NCT02686762EMRICASANPHASE2ClinicalTrials.gov
NCT02230683EMRICASANPHASE22016-12-21ClinicalTrials.gov
NCT02230670EMRICASANPHASE22017-07-05ClinicalTrials.gov
NCT02138253EMRICASANPHASE22019-12-11ClinicalTrials.gov
NCT02077374EMRICASANPHASE22016-07-21ClinicalTrials.gov
NCT01937130EMRICASANPHASE22016-04-11ClinicalTrials.gov
NCT01912404EMRICASANPHASE22016-11-04ClinicalTrials.gov
NCT01653899EMRICASANPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants2,142

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCASP2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant122025
P01CA097132Sphingolipids in Cancer Biology and Therapy82025
R01DK120714Control of Lipogenesis and Hepatic Steatosis by Caspase-262025
P30CA016056Roswell Park Cancer Center Support Grant52025
P30CA021765Cancer Center Support Grant (CCSG)52025
P30CA054174Mays Cancer Center at UT Health SA52025
P30CA068485Cancer Center Support Grant52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P50AA011999Southern California Research Center for ALPD and Cirrhosis52025
R01GM135301A Non-Canonical IRAK1 Signaling Pathway Triggered by Ionizing Radiation52025

1 to 10 of 2,142Source NIH's project files

See all 2,142 nih grants

Papers3,745

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Methods to study PIDDosome and caspase-2 signalling.Methods Cell Biol202642692556PubTator, text miningPubMed
The truncated Tau fragment 315-441 produced by Caspase-2 translocates to the nucleus and alters the proteome of neuroblastoma cells.Eur J Cell Biol202642659873PubTator, text miningPubMed
Caspase-2 is involved in IFN-γ primed THP-1 derived macrophages cell death through regulating caspase-8 activation.Hum Immunol202642632271PubTator, text miningPubMed
A Distinct c-Raf-MEK1/2-p38 MAPK-Caspase Signaling Pathway Mediates TNF-α-Induced Rapid and Non-Lytic Neutrophil Extracellular Trap Formation in Human Neutrophil-Like Cells.J Interferon Cytokine Res202642565367PubTator, text miningPubMed
Apoptosis protein markers in comorbid type 2 diabetes mellitus and depression; relationships with cognitive performance, incident dementia, and white matter hyperintensities.J Affect Disord202642556583PubTator, text miningPubMed
S100A11 regulates hepatic cholesterol metabolism and promotes steatohepatitis via noncanonical SREBP2 signaling.J Clin Invest202642550612PubTator, text miningPubMed
Comprehensive Experimental and Computational Characterization of a Phenylacetamide-Based Molecule.Biomed Res Int202642446101PubTator, text miningPubMed
Correction: An unexpected role for caspase-2 in neuroblastoma.Cell Death Dis202642414256PubTator, text miningPubMed
Intervening in p53-Induced Death Domain Protein 1 to Decrease Regulatory T Cell Recruitment Boosts the Effectiveness of Radiofrequency Ablation Combined With Anti-Programmed Cell Death Protein-1 Therapy in Hepatocellular Carcinoma.
Cell Mol Gastroenterol Hepatol202642398821PubTator, text miningPubMed
Pulsed Electromagnetic Field Increases Doxorubicin-induced Mitotic Slippage in MDA-MB-231 Breast Cancer Cells.Anticancer Res202642373288PubTator, text miningPubMed

1 to 10 of 3,745

See all 3,745 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/835

GET https://conductscience.org/api/genes/v1/835/patents?page=2