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CASP3: caspase 3

1 protein, 176 patents, 1 drug, 11 trials, 29,773 NIH grants and 140,116 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCASP3HGNC
Namecaspase 3HGNC
NCBI Gene ID836NCBI Gene
HGNC IDHGNC:1504HGNC
EnsemblENSG00000164305NCBI Gene
AliasesCPP32, CPP32B, SCA-1, Yama, apopainNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P42574Caspase-3277135Ensembl, GeneID, HGNCUniProt

Patents 176

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4774398 A12026-07-1552P42574Espacenet
US 12539325 B22026-02-0320P42574Espacenet
JP 2026004568 A2026-01-1440216P42574Espacenet
JP 2026004568 A2026-01-1440219P42574Espacenet
JP 2026000906 A2026-01-06136P42574Espacenet
JP 2025183238 A2025-12-162P42574Espacenet
EP 4650780 A22025-11-194727P42574Espacenet
JP 2025161810 A2025-10-2421P42574Espacenet
JP 2025147176 A2025-10-0616531P42574Espacenet
WO 2025132695 A12025-06-2661P42574Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EMRICASANCHEMBL197672Caspase inhibitorINHIBITORChEMBL

Trials 11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04803227EMRICASANPHASE1ClinicalTrials.gov
NCT03205345EMRICASANPHASE2ClinicalTrials.gov
NCT02686762EMRICASANPHASE2ClinicalTrials.gov
NCT02230683EMRICASANPHASE22016-12-21ClinicalTrials.gov
NCT02230670EMRICASANPHASE22017-07-05ClinicalTrials.gov
NCT02138253EMRICASANPHASE22019-12-11ClinicalTrials.gov
NCT02077374EMRICASANPHASE22016-07-21ClinicalTrials.gov
NCT01937130EMRICASANPHASE22016-04-11ClinicalTrials.gov
NCT01912404EMRICASANPHASE22016-11-04ClinicalTrials.gov
NCT01653899EMRICASANPHASE1/PHASE2ClinicalTrials.gov

NIH grants 29773

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant6102,025NIH's project files
P30CA008748Cancer Center Support Grant2582,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant1102,025NIH's project files
P30CA016058Cancer Center Support Grant1072,025NIH's project files
P30CA047904Cancer Center Support Grant1072,025NIH's project files
P30CA068485Cancer Center Support Grant1012,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant932,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant882,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028842,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program782,025NIH's project files

Papers 140116

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826809PubTator, text miningPubMed
42825943PubTator, text miningPubMed
42823178PubTator, text miningPubMed
42820025PubTator, text miningPubMed
42818881PubTator, text miningPubMed
42817588PubTator, text miningPubMed
42815651PubTator, text miningPubMed
42815581PubTator, text miningPubMed
42815168PubTator, text miningPubMed
42815086PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license