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Gene · 837

CASP4: caspase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CASP4: caspase 4. Genes, record 837. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/837

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Gene

Symbol
CASP4
HGNC
Name
caspase 4
HGNC
NCBI Gene ID
837
NCBI Gene
HGNC ID
HGNC:1505
HGNC
Ensembl
ENSG00000196954
NCBI Gene
Aliases
CASP-4, ICE(rel)II, ICEREL-II, ICH-2, Mih1, Mih1/TX, TX
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49662Caspase-437711Ensembl, GeneID, HGNC

Source UniProt

Patents88

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0321P49662Espacenet
EP 4650780 A22025-11-1912252P49662Espacenet
JP 2025517970 A2025-06-1212252P49662Espacenet
JP 2025062604 A2025-04-1412262P49662Espacenet
JP 2025032204 A2025-03-1125832P49662Espacenet
EP 4461818 A22024-11-1325832P49662Espacenet
US 12133879 B22024-11-0521P49662Espacenet
JP 2024123008 A2024-09-105341P49662Espacenet
US 11926860 B22024-03-121P49662Espacenet
US 11872193 B22024-01-1621P49662Espacenet

1 to 10 of 88

See all 88 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
EMRICASANCHEMBL197672Caspase inhibitorINHIBITOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04803227EMRICASANPHASE1ClinicalTrials.gov
NCT03205345EMRICASANPHASE2ClinicalTrials.gov
NCT02686762EMRICASANPHASE2ClinicalTrials.gov
NCT02230683EMRICASANPHASE22016-12-21ClinicalTrials.gov
NCT02230670EMRICASANPHASE22017-07-05ClinicalTrials.gov
NCT02138253EMRICASANPHASE22019-12-11ClinicalTrials.gov
NCT02077374EMRICASANPHASE22016-07-21ClinicalTrials.gov
NCT01937130EMRICASANPHASE22016-04-11ClinicalTrials.gov
NCT01912404EMRICASANPHASE22016-11-04ClinicalTrials.gov
NCT01653899EMRICASANPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants1,746

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCASP4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
R01AI124491NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing92025
R01AI124346Innate immune signaling and stress response82025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation72025
P30DK034854Integrated Epithelial and Muscosal Biology62025
R01AI118861Innate immune-mediated control of pulmonary Legionella pneumophila infection62025
P30CA008748Cancer Center Support Grant52025
P30CA016058Cancer Center Support Grant52025
P51OD011132Emory National Primate Research Center52025
R01AI108834GBPs in inflammasome activation and host defense to infection52025

1 to 10 of 1,746Source NIH's project files

See all 1,746 nih grants

Papers3,388

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Effects of Propofol-remifentanil on Apoptotic Molecules, Plasma CXCL10, and CXCL13 in Pancreatic Cancer Patients.Iran J Allergy Asthma Immunol202642801781PubTator, text miningPubMed
Machine learning identifies autophagy biomarkers driving microvascular injury in cardiac ischemia/reperfusion.Adv Clin Exp Med202642755100PubTator, text miningPubMed
When folding CARDs wins the game: molecular snapshots of lipopolysaccharide sensing by the non-canonical inflammasome.Biochem Soc Trans202642719947PubTator, text miningPubMed
An integrated systems biology and machine learning framework for identifying potential biomarkers and pathways in autism spectrum disorder.PLoS One202642636188PubTator, text miningPubMed
Association of bronchoalveolar lavage fluid caspase-4 with inflammatory responses in pediatric acute respiratory distress syndrome.Transl Pediatr202642591659PubTator, text miningPubMed
The dynamic and heterogeneous structure of the non-canonical inflammasome.Proc Natl Acad Sci U S A202642546204PubTator, text miningPubMed
Cryo-EM structures of human caspase-4 in complex with full-length gasdermin D.Structure202642442362PubTator, text miningPubMed
Transcriptomics, lifestyle, and autoimmune thyroiditis: an integrated association study.Front Immunol202642421942PubTator, text miningPubMed
Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma.Ann Clin Transl Neurol202642421178PubTator, text miningPubMed
Corrigendum to "Phillyrin ameliorates sepsis via targeting microRNA-203a-mediated caspase-4/caspase-11/caspase-B downregulation to suppress endothelial pyroptosis" [Phytomedicine 152 (2026) 157872].Phytomedicine202642372604PubTator, text miningPubMed

1 to 10 of 3,388

See all 3,388 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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