Gene · 837
CASP4: caspase 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CASP4: caspase 4. Genes, record 837. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/837
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49662 | Caspase-4 | 377 | 11 | Ensembl, GeneID, HGNC |
Source UniProt
Patents88
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12539325 B2 | 2026-02-03 | 21 | P49662 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 12252 | P49662 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 12252 | P49662 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 12262 | P49662 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 25832 | P49662 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 25832 | P49662 | Espacenet |
| US 12133879 B2 | 2024-11-05 | 21 | P49662 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 5341 | P49662 | Espacenet |
| US 11926860 B2 | 2024-03-12 | 1 | P49662 | Espacenet |
| US 11872193 B2 | 2024-01-16 | 21 | P49662 | Espacenet |
1 to 10 of 88
See all 88 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| EMRICASAN | CHEMBL197672 | Caspase inhibitor | INHIBITOR |
Source ChEMBL
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04803227 | EMRICASAN | PHASE1 | ClinicalTrials.gov | |
| NCT03205345 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02686762 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02230683 | EMRICASAN | PHASE2 | 2016-12-21 | ClinicalTrials.gov |
| NCT02230670 | EMRICASAN | PHASE2 | 2017-07-05 | ClinicalTrials.gov |
| NCT02138253 | EMRICASAN | PHASE2 | 2019-12-11 | ClinicalTrials.gov |
| NCT02077374 | EMRICASAN | PHASE2 | 2016-07-21 | ClinicalTrials.gov |
| NCT01937130 | EMRICASAN | PHASE2 | 2016-04-11 | ClinicalTrials.gov |
| NCT01912404 | EMRICASAN | PHASE2 | 2016-11-04 | ClinicalTrials.gov |
| NCT01653899 | EMRICASAN | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants1,746
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CASP4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| R01AI124491 | NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing | 9 | 2025 |
| R01AI124346 | Innate immune signaling and stress response | 8 | 2025 |
| R37AI101935 | Inflammatory Caspases in Innate Immunity and Inflammation | 7 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 6 | 2025 |
| R01AI118861 | Innate immune-mediated control of pulmonary Legionella pneumophila infection | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 5 | 2025 |
| P51OD011132 | Emory National Primate Research Center | 5 | 2025 |
| R01AI108834 | GBPs in inflammasome activation and host defense to infection | 5 | 2025 |
1 to 10 of 1,746Source NIH's project files
See all 1,746 nih grantsPapers3,388
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Effects of Propofol-remifentanil on Apoptotic Molecules, Plasma CXCL10, and CXCL13 in Pancreatic Cancer Patients. | Iran J Allergy Asthma Immunol | 2026 | 42801781 | PubTator, text mining | PubMed |
| Machine learning identifies autophagy biomarkers driving microvascular injury in cardiac ischemia/reperfusion. | Adv Clin Exp Med | 2026 | 42755100 | PubTator, text mining | PubMed |
| When folding CARDs wins the game: molecular snapshots of lipopolysaccharide sensing by the non-canonical inflammasome. | Biochem Soc Trans | 2026 | 42719947 | PubTator, text mining | PubMed |
| An integrated systems biology and machine learning framework for identifying potential biomarkers and pathways in autism spectrum disorder. | PLoS One | 2026 | 42636188 | PubTator, text mining | PubMed |
| Association of bronchoalveolar lavage fluid caspase-4 with inflammatory responses in pediatric acute respiratory distress syndrome. | Transl Pediatr | 2026 | 42591659 | PubTator, text mining | PubMed |
| The dynamic and heterogeneous structure of the non-canonical inflammasome. | Proc Natl Acad Sci U S A | 2026 | 42546204 | PubTator, text mining | PubMed |
| Cryo-EM structures of human caspase-4 in complex with full-length gasdermin D. | Structure | 2026 | 42442362 | PubTator, text mining | PubMed |
| Transcriptomics, lifestyle, and autoimmune thyroiditis: an integrated association study. | Front Immunol | 2026 | 42421942 | PubTator, text mining | PubMed |
| Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma. | Ann Clin Transl Neurol | 2026 | 42421178 | PubTator, text mining | PubMed |
| Corrigendum to "Phillyrin ameliorates sepsis via targeting microRNA-203a-mediated caspase-4/caspase-11/caspase-B downregulation to suppress endothelial pyroptosis" [Phytomedicine 152 (2026) 157872]. | Phytomedicine | 2026 | 42372604 | PubTator, text mining | PubMed |
1 to 10 of 3,388
See all 3,388 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/837
GET https://conductscience.org/api/genes/v1/837/patents?page=2