Gene · 83737
ITCH: itchy E3 ubiquitin protein ligase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ITCH: itchy E3 ubiquitin protein ligase. Genes, record 83737. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/83737
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96J02 | E3 ubiquitin-protein ligase Itchy homolog | 903 | 12 | Ensembl, GeneID, HGNC |
Source UniProt
Patents34
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026509876 A | 2026-03-25 | 31 | Q96J02 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50466 | Q96J02 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2105 | Q96J02 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1666 | Q96J02 | Espacenet |
| JP 2025532963 A | 2025-10-03 | 31 | Q96J02 | Espacenet |
| EP 4593805 A2 | 2025-08-06 | 31 | Q96J02 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1666 | Q96J02 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2105 | Q96J02 | Espacenet |
| EP 4540277 A2 | 2025-04-23 | 31 | Q96J02 | Espacenet |
| EP 4493157 A2 | 2025-01-22 | 34 | Q96J02 | Espacenet |
1 to 10 of 34
See all 34 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,761
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ITCH papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| T32ES012870 | Graduate and Postdoctoral Training in Environmental Health Science and Toxicology | 4 | 2025 |
| K12GM068524 | San Diego IRACDA Scholars Program | 3 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 3 | 2025 |
| P30CA056036 | Translational Research in Cancer | 3 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 3 | 2025 |
1 to 10 of 1,761Source NIH's project files
See all 1,761 nih grantsPapers2,772
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Neddylation-triggered ubiquitination and proteasomal degradation of HELLS inhibits prostate cancer growth via genomic instability. | Biochim Biophys Acta Mol Basis Dis | 2027 | 42607898 | PubTator, text mining | PubMed |
| Analyzing the cytotoxicity and pro-tumorigenic role of acetyl tributyl citrate in prostate through network toxicology and the immune microenvironment. | Front Immunol | 2026 | 42807872 | PubTator, text mining | PubMed |
| Defective ATP13A2-ITCH-ALIX signaling impairs intraluminal vesicle biogenesis and increases neuronal vulnerability. | Cell Signal | 2026 | 42762936 | PubTator, text mining | PubMed |
| Regulation of ubiquitination and degradation of the gap junction channel protein Connexin43 involves the concerted action of multiple members of the NEDD4 family of E3 ubiquitin ligases. | Cancer Lett | 2026 | 42641867 | PubTator, text mining | PubMed |
| circ-ITCH suppresses prostate cancer cell proliferation, migration and invasion in-vitro through the miR-106b-5p/SETD2 axis. | Pak J Pharm Sci | 2026 | 42633546 | PubTator, text mining | PubMed |
| CHFR drives gastric cancer stemness and hepatic metastasis by suppressing ITCH-mediated ubiquitination and degradation of OCT4. | Biol Direct | 2026 | 42618938 | PubTator, text mining | PubMed |
| Development of itch biosensors with engineering membrane receptors that are coupled to field-effect transistors. | Biosens Bioelectron | 2026 | 42531649 | PubTator, text mining | PubMed |
| Integrative Observational and Genetic Evidence From the UK Biobank Supports Carotid Intima-Media Thickness as a Window Into Cardiac Remodeling. | J Am Heart Assoc | 2026 | 42396779 | PubTator, text mining | PubMed |
| WWOX contributes to DNA damage, but not somatic instability in Huntington's disease. | bioRxiv | 2026 | 42395553 | PubTator, text mining | PubMed |
| KSTITCH links cellular morphology and gene expression in spatial transcriptomics. | bioRxiv | 2026 | 42327255 | PubTator, text mining | PubMed |
1 to 10 of 2,772
See all 2,772 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/83737
GET https://conductscience.org/api/genes/v1/83737/patents?page=2