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Gene · 83737

ITCH: itchy E3 ubiquitin protein ligase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ITCH: itchy E3 ubiquitin protein ligase. Genes, record 83737. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/83737

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Gene

Symbol
ITCH
HGNC
Name
itchy E3 ubiquitin protein ligase
HGNC
NCBI Gene ID
83737
NCBI Gene
HGNC ID
HGNC:13890
HGNC
Ensembl
ENSG00000078747
NCBI Gene
Aliases
ADMFD, AIF4, AIP4, NAPP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96J02E3 ubiquitin-protein ligase Itchy homolog90312Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026509876 A2026-03-2531Q96J02Espacenet
JP 2026004568 A2026-01-1450466Q96J02Espacenet
EP 4650780 A22025-11-192105Q96J02Espacenet
EP 4641201 A22025-10-291666Q96J02Espacenet
JP 2025532963 A2025-10-0331Q96J02Espacenet
EP 4593805 A22025-08-0631Q96J02Espacenet
JP 2025517969 A2025-06-121666Q96J02Espacenet
JP 2025517970 A2025-06-122105Q96J02Espacenet
EP 4540277 A22025-04-2331Q96J02Espacenet
EP 4493157 A22025-01-2234Q96J02Espacenet

1 to 10 of 34

See all 34 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,761

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleITCH papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
T32ES012870Graduate and Postdoctoral Training in Environmental Health Science and Toxicology42025
K12GM068524San Diego IRACDA Scholars Program32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA008748Cancer Center Support Grant32025
P30CA014195Cancer Center Support Grant (CCSG)32025
P30CA021765Cancer Center Support Grant (CCSG)32025
P30CA047904Cancer Center Support Grant32025
P30CA056036Translational Research in Cancer32025
P30DK034854Integrated Epithelial and Muscosal Biology32025

1 to 10 of 1,761Source NIH's project files

See all 1,761 nih grants

Papers2,772

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Neddylation-triggered ubiquitination and proteasomal degradation of HELLS inhibits prostate cancer growth via genomic instability.Biochim Biophys Acta Mol Basis Dis202742607898PubTator, text miningPubMed
Analyzing the cytotoxicity and pro-tumorigenic role of acetyl tributyl citrate in prostate through network toxicology and the immune microenvironment.Front Immunol202642807872PubTator, text miningPubMed
Defective ATP13A2-ITCH-ALIX signaling impairs intraluminal vesicle biogenesis and increases neuronal vulnerability.Cell Signal202642762936PubTator, text miningPubMed
Regulation of ubiquitination and degradation of the gap junction channel protein Connexin43 involves the concerted action of multiple members of the NEDD4 family of E3 ubiquitin ligases.Cancer Lett202642641867PubTator, text miningPubMed
circ-ITCH suppresses prostate cancer cell proliferation, migration and invasion in-vitro through the miR-106b-5p/SETD2 axis.Pak J Pharm Sci202642633546PubTator, text miningPubMed
CHFR drives gastric cancer stemness and hepatic metastasis by suppressing ITCH-mediated ubiquitination and degradation of OCT4.Biol Direct202642618938PubTator, text miningPubMed
Development of itch biosensors with engineering membrane receptors that are coupled to field-effect transistors.Biosens Bioelectron202642531649PubTator, text miningPubMed
Integrative Observational and Genetic Evidence From the UK Biobank Supports Carotid Intima-Media Thickness as a Window Into Cardiac Remodeling.J Am Heart Assoc202642396779PubTator, text miningPubMed
WWOX contributes to DNA damage, but not somatic instability in Huntington's disease.bioRxiv202642395553PubTator, text miningPubMed
KSTITCH links cellular morphology and gene expression in spatial transcriptomics.bioRxiv202642327255PubTator, text miningPubMed

1 to 10 of 2,772

See all 2,772 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/83737

GET https://conductscience.org/api/genes/v1/83737/patents?page=2