ConductScience.org, home

Gene · 838

CASP5: caspase 5

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. CASP5: caspase 5. Genes, record 838. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/838

On this page

Gene

Symbol
CASP5
HGNC
Name
caspase 5
HGNC
NCBI Gene ID
838
NCBI Gene
HGNC ID
HGNC:1506
HGNC
Ensembl
ENSG00000137757
NCBI Gene
Aliases
ICE(rel)III, ICEREL-III, ICH-3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51878Caspase-54340Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0322P51878Espacenet
EP 4641201 A22025-10-291378P51878Espacenet
JP 2025517969 A2025-06-121378P51878Espacenet
JP 2025062604 A2025-04-1412266P51878Espacenet
US 12133879 B22024-11-0522P51878Espacenet
JP 2024123008 A2024-09-105342P51878Espacenet
US 11872193 B22024-01-1622P51878Espacenet
JP 2023545821 A2023-10-3129P51878Espacenet
JP 2023545178 A2023-10-2637P51878Espacenet
JP 2023542297 A2023-10-0634P51878Espacenet

1 to 10 of 30

See all 30 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
EMRICASANCHEMBL197672Caspase inhibitorINHIBITOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04803227EMRICASANPHASE1ClinicalTrials.gov
NCT03205345EMRICASANPHASE2ClinicalTrials.gov
NCT02686762EMRICASANPHASE2ClinicalTrials.gov
NCT02230683EMRICASANPHASE22016-12-21ClinicalTrials.gov
NCT02230670EMRICASANPHASE22017-07-05ClinicalTrials.gov
NCT02138253EMRICASANPHASE22019-12-11ClinicalTrials.gov
NCT02077374EMRICASANPHASE22016-07-21ClinicalTrials.gov
NCT01937130EMRICASANPHASE22016-04-11ClinicalTrials.gov
NCT01912404EMRICASANPHASE22016-11-04ClinicalTrials.gov
NCT01653899EMRICASANPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants1,015

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCASP5 papersNewest fiscal year
R01AI124346Innate immune signaling and stress response62025
R01AI124491NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing62025
R01GM100482Center for Critical Assessment of Structure Prediction (CASP)62025
P30DK034854Integrated Epithelial and Muscosal Biology52025
R01AI118861Innate immune-mediated control of pulmonary Legionella pneumophila infection52025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation52025
P30CA008748Cancer Center Support Grant42025
P30CA030199Cancer Center Support Grant (CCSG)42025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA016086Cancer Center Support Grant32025

1 to 10 of 1,015Source NIH's project files

See all 1,015 nih grants

Papers1,806

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
When folding CARDs wins the game: molecular snapshots of lipopolysaccharide sensing by the non-canonical inflammasome.Biochem Soc Trans202642719947PubTator, text miningPubMed
Transcription-protein dissociation reveals disrupted cellular stress pathways in the prefrontal cortex of depression and schizophrenia subjects.Mol Biomed202642606669PubTator, text miningPubMed
The dynamic and heterogeneous structure of the non-canonical inflammasome.Proc Natl Acad Sci U S A202642546204PubTator, text miningPubMed
GSDMB as a Therapeutic and Prognostic Target in Clear Cell Renal Cell Carcinoma: Insights From Pyroptosis-Related Gene Analysis.Front Biosci (Landmark Ed)202642530271PubTator, text miningPubMed
Immune-stromal dysregulation and senescence in chronic spontaneous urticaria.J Allergy Clin Immunol Glob202642436760PubTator, text miningPubMed
Dementia, mood disorders, and aging: Bridging new avenues of care through shared biological pathways.Aging Adv202642370305PubTator, text miningPubMed
Co-expression of MARCKS and GSDMD pathway genes in tuberculous meningitis: a multi-omics analysis of blood-brain barrier disruption.Front Cell Infect Microbiol202642318017PubTator, text miningPubMed
Determination of protein markers of inflammasome formation and ferroptosis in thyroid cancer based on gender.J Cancer202642179791PubTator, text miningPubMed
Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages.PLoS Pathog202642044191PubTator, text miningPubMed
The dynamic and heterogeneous structure of the non-canonical inflammasome.bioRxiv202642039641PubTator, text miningPubMed

1 to 10 of 1,806

See all 1,806 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/838

GET https://conductscience.org/api/genes/v1/838/patents?page=2