Gene · 838
CASP5: caspase 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CASP5: caspase 5. Genes, record 838. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/838
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P51878 | Caspase-5 | 434 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12539325 B2 | 2026-02-03 | 22 | P51878 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1378 | P51878 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1378 | P51878 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 12266 | P51878 | Espacenet |
| US 12133879 B2 | 2024-11-05 | 22 | P51878 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 5342 | P51878 | Espacenet |
| US 11872193 B2 | 2024-01-16 | 22 | P51878 | Espacenet |
| JP 2023545821 A | 2023-10-31 | 29 | P51878 | Espacenet |
| JP 2023545178 A | 2023-10-26 | 37 | P51878 | Espacenet |
| JP 2023542297 A | 2023-10-06 | 34 | P51878 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| EMRICASAN | CHEMBL197672 | Caspase inhibitor | INHIBITOR |
Source ChEMBL
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04803227 | EMRICASAN | PHASE1 | ClinicalTrials.gov | |
| NCT03205345 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02686762 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02230683 | EMRICASAN | PHASE2 | 2016-12-21 | ClinicalTrials.gov |
| NCT02230670 | EMRICASAN | PHASE2 | 2017-07-05 | ClinicalTrials.gov |
| NCT02138253 | EMRICASAN | PHASE2 | 2019-12-11 | ClinicalTrials.gov |
| NCT02077374 | EMRICASAN | PHASE2 | 2016-07-21 | ClinicalTrials.gov |
| NCT01937130 | EMRICASAN | PHASE2 | 2016-04-11 | ClinicalTrials.gov |
| NCT01912404 | EMRICASAN | PHASE2 | 2016-11-04 | ClinicalTrials.gov |
| NCT01653899 | EMRICASAN | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants1,015
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CASP5 papers | Newest fiscal year |
|---|---|---|---|
| R01AI124346 | Innate immune signaling and stress response | 6 | 2025 |
| R01AI124491 | NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing | 6 | 2025 |
| R01GM100482 | Center for Critical Assessment of Structure Prediction (CASP) | 6 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 5 | 2025 |
| R01AI118861 | Innate immune-mediated control of pulmonary Legionella pneumophila infection | 5 | 2025 |
| R37AI101935 | Inflammatory Caspases in Innate Immunity and Inflammation | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,015Source NIH's project files
See all 1,015 nih grantsPapers1,806
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| When folding CARDs wins the game: molecular snapshots of lipopolysaccharide sensing by the non-canonical inflammasome. | Biochem Soc Trans | 2026 | 42719947 | PubTator, text mining | PubMed |
| Transcription-protein dissociation reveals disrupted cellular stress pathways in the prefrontal cortex of depression and schizophrenia subjects. | Mol Biomed | 2026 | 42606669 | PubTator, text mining | PubMed |
| The dynamic and heterogeneous structure of the non-canonical inflammasome. | Proc Natl Acad Sci U S A | 2026 | 42546204 | PubTator, text mining | PubMed |
| GSDMB as a Therapeutic and Prognostic Target in Clear Cell Renal Cell Carcinoma: Insights From Pyroptosis-Related Gene Analysis. | Front Biosci (Landmark Ed) | 2026 | 42530271 | PubTator, text mining | PubMed |
| Immune-stromal dysregulation and senescence in chronic spontaneous urticaria. | J Allergy Clin Immunol Glob | 2026 | 42436760 | PubTator, text mining | PubMed |
| Dementia, mood disorders, and aging: Bridging new avenues of care through shared biological pathways. | Aging Adv | 2026 | 42370305 | PubTator, text mining | PubMed |
| Co-expression of MARCKS and GSDMD pathway genes in tuberculous meningitis: a multi-omics analysis of blood-brain barrier disruption. | Front Cell Infect Microbiol | 2026 | 42318017 | PubTator, text mining | PubMed |
| Determination of protein markers of inflammasome formation and ferroptosis in thyroid cancer based on gender. | J Cancer | 2026 | 42179791 | PubTator, text mining | PubMed |
| Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages. | PLoS Pathog | 2026 | 42044191 | PubTator, text mining | PubMed |
| The dynamic and heterogeneous structure of the non-canonical inflammasome. | bioRxiv | 2026 | 42039641 | PubTator, text mining | PubMed |
1 to 10 of 1,806
See all 1,806 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/838
GET https://conductscience.org/api/genes/v1/838/patents?page=2