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Gene · 839

CASP6: caspase 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CASP6: caspase 6. Genes, record 839. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/839

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Gene

Symbol
CASP6
HGNC
Name
caspase 6
HGNC
NCBI Gene ID
839
NCBI Gene
HGNC ID
HGNC:1507
HGNC
Ensembl
ENSG00000138794
NCBI Gene
Aliases
CSP-6, MCH2, caspase-6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P55212Caspase-629337Ensembl, GeneID, HGNC

Source UniProt

Patents75

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0323P55212Espacenet
JP 2025183238 A2025-12-161P55212Espacenet
EP 4641202 A22025-10-294590P55212Espacenet
EP 4634158 A22025-10-221P55212Espacenet
JP 2025147176 A2025-10-0616532P55212Espacenet
JP 2025062604 A2025-04-1412275P55212Espacenet
JP 2025028160 A2025-02-2816532P55212Espacenet
KR 1020250017231 A2025-02-044590P55212Espacenet
KR 1020250010750 A2025-01-2116532P55212Espacenet
US 12133879 B22024-11-0523P55212Espacenet

1 to 10 of 75

See all 75 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
EMRICASANCHEMBL197672Caspase inhibitorINHIBITOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04803227EMRICASANPHASE1ClinicalTrials.gov
NCT03205345EMRICASANPHASE2ClinicalTrials.gov
NCT02686762EMRICASANPHASE2ClinicalTrials.gov
NCT02230683EMRICASANPHASE22016-12-21ClinicalTrials.gov
NCT02230670EMRICASANPHASE22017-07-05ClinicalTrials.gov
NCT02138253EMRICASANPHASE22019-12-11ClinicalTrials.gov
NCT02077374EMRICASANPHASE22016-07-21ClinicalTrials.gov
NCT01937130EMRICASANPHASE22016-04-11ClinicalTrials.gov
NCT01912404EMRICASANPHASE22016-11-04ClinicalTrials.gov
NCT01653899EMRICASANPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants1,719

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCASP6 papersNewest fiscal year
R01AI124346Innate immune signaling and stress response162025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation152025
R35CA253095Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer122025
P30CA016672Cancer Center Support Grant102025
R01AI160179Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases92025
K24AG053435Neuropathological changes underlying clinical heterogeneity in Alzheimer disease52025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions42025
P30CA016056Roswell Park Cancer Center Support Grant42025
P01CA013106Targeting Transcription and Splicing in Cancer32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025

1 to 10 of 1,719Source NIH's project files

See all 1,719 nih grants

Papers3,659

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated proteomics and network pharmacology reveal autophagy-lysosomal regulation underlying sulforaphane-mediated neuroprotection in Alzheimer's disease.Brain Res202642735792PubTator, text miningPubMed
ScGraphTrans: Pathway-Guided Graph Learning and Domain Adaptation for Cell Type Annotation in Single-Cell RNA-seq.IEEE Trans Comput Biol Bioinform202642721175PubTator, text miningPubMed
Integrated genome-wide high-throughput screening and functional validation identifies Sm proteins as essential splicing regulators for gastric cancer progression.Funct Integr Genomics202642640343PubTator, text miningPubMed
In silico investigation of novel isatin derivatives as potential multi-target anticancer agents targeting VEGFR-2, EGFR, and caspase-6.J Recept Signal Transduct Res202642542991PubTator, text miningPubMed
Structure-activity relationship studies of febuxostat derivatives identify potent anti-lung cancer agents that induce DNA damage and autophagy.Sci Rep202642481535PubTator, text miningPubMed
Construction and validation of a model based on necroptosis-related genes for predicting glioma prognosis.Discov Oncol202642274952PubTator, text miningPubMed
Pathogenic human huntingtin expression causes prolific intramuscular aggregation, leading to nuclear, metabolic, and physiological dysregulation in striated muscle.bioRxiv202642079048PubTator, text miningPubMed
Porcine reproductive and respiratory syndrome virus N protein-mediated viral replication enhancement via interaction with host caspase-6.J Virol202641979901PubTator, text miningPubMed
Targeting BCL-xL in Myeloid Malignancies: From Inhibitors to PROTAC.J Cell Mol Med202641937490PubTator, text miningPubMed
The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design.ChemMedChem202641931005PubTator, text miningPubMed

1 to 10 of 3,659

See all 3,659 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/839

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