Gene · 83933
HDAC10: histone deacetylase 10
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HDAC10: histone deacetylase 10. Genes, record 83933. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/83933
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q969S8 | Polyamine deacetylase HDAC10 | 669 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 246 | Q969S8 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1927 | Q969S8 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1927 | Q969S8 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 246 | Q969S8 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 4704 | Q969S8 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 38556 | Q969S8 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 141527 | Q969S8 | Espacenet |
| JP 2021516765 A | 2021-07-08 | 18 | Q969S8 | Espacenet |
| KR 1020200135994 A | 2020-12-04 | 18 | Q969S8 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 1089 | Q969S8 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs12
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABEXINOSTAT | CHEMBL2103863 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| BELINOSTAT | CHEMBL408513 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| CUDC-101 | CHEMBL598797 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| ENTINOSTAT | CHEMBL27759 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| FIMEPINOSTAT | CHEMBL3622533 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| GIVINOSTAT | CHEMBL1213492 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| GIVINOSTAT HYDROCHLORIDE | CHEMBL6068400 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| PANOBINOSTAT | CHEMBL483254 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| PANOBINOSTAT LACTATE | CHEMBL3545368 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| QUISINOSTAT | CHEMBL2105763 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
1 to 10 of 12
See all 12 drugsTrials389
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07492394 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT07441486 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT07330544 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT07261592 | ENTINOSTAT | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07235618 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT06824662 | QUISINOSTAT | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT06769633 | GIVINOSTAT HYDROCHLORIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06561048 | BELINOSTAT | PHASE3 | ClinicalTrials.gov | |
| NCT06406465 | BELINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT06240520 | PANOBINOSTAT | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 389
See all 389 trialsNIH grants687
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HDAC10 papers | Newest fiscal year |
|---|---|---|---|
| R01GM049758 | Structure and Function of Metalloenzymes | 21 | 2025 |
| P30GM124165 | NE-CAT: A Resource for Advanced Macromolecular Crystallography | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30GM133893 | Center for Biomolecular Structure (CBMS) | 4 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 3 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 2 | 2025 |
| P30CA022453 | CANCER CENTER SUPPORT GRANT | 2 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 687Source NIH's project files
See all 687 nih grantsPapers1,263
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Discovery of first histone deacetylase 10 fluorescent probe. | Bioorg Chem | 2026 | 42826658 | PubTator, text mining | PubMed |
| Molecular mechanisms of maturation in neurogenic embryonal tumors of peripheral and central localization. | J Neuropathol Exp Neurol | 2026 | 42727056 | PubTator, text mining | PubMed |
| Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart. | J Precis Med (Amst) | 2026 | 42644057 | PubTator, text mining | PubMed |
| HDAC inhibitors as ferroptosis sensitizers in cancer: Epigenetic regulation of redox balance and iron metabolism. | EXCLI J | 2026 | 42517085 | PubTator, text mining | PubMed |
| miR-320d Is Associated with Reduced Nasopharyngeal Carcinoma Progression, Potentially through the NF-κB/IL-8 Axis-Mediated Inhibition of Neutrophil Extracellular Trap Formation. | Oncol Res | 2026 | 42500573 | PubTator, text mining | PubMed |
| Design, Synthesis, and Biological Evaluation of Novel PAK1/HDAC10 Dual Inhibitors That Activate Antitumor Immunity for Triple-Negative Breast Cancer Treatment. | J Med Chem | 2026 | 42418247 | PubTator, text mining | PubMed |
| HDAC10 promotes Th17 differentiation and IL-17A-driven neutrophilic airway inflammation in severe asthma. | Cell Rep | 2026 | 42384487 | PubTator, text mining | PubMed |
| Monocytes from patients with chronic non-bacterial osteomyelitis (CNO) exhibit increased 'classically activated' phenotypes and altered DNA methylation patterns. | Clin Immunol | 2026 | 42142821 | PubTator, text mining | PubMed |
| Histone Deacetylase 10 Inhibitors Suppress Progression of Endometriosis via Activation of Interferon Regulatory Factor 6 and Dachshund Homolog 1. | J Obstet Gynaecol Res | 2026 | 42091420 | PubTator, text mining | PubMed |
| Estrogen, Epigenetics, and Cardiometabolic Health: Mechanisms and Therapeutic Strategies in Postmenopausal Women. | Cells | 2026 | 41892319 | PubTator, text mining | PubMed |
1 to 10 of 1,263
See all 1,263 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/83933
GET https://conductscience.org/api/genes/v1/83933/patents?page=2