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Gene · 8398

PLA2G6: phospholipase A2 group VI

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PLA2G6: phospholipase A2 group VI. Genes, record 8398. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8398

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Gene

Symbol
PLA2G6
HGNC
Name
phospholipase A2 group VI
HGNC
NCBI Gene ID
8398
NCBI Gene
HGNC ID
HGNC:9039
HGNC
Ensembl
ENSG00000184381
NCBI Gene
Aliases
CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2, iPLA2beta
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O6073385/88 kDa calcium-independent phospholipase A28060Ensembl, GeneID, HGNC

Source UniProt

Patents64

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026108757 A2026-06-3072O60733Espacenet
JP 2026108757 A2026-06-3075O60733Espacenet
EP 4641201 A22025-10-295740O60733Espacenet
JP 2025529142 A2025-09-043509O60733Espacenet
US 12371689 B22025-07-293509O60733Espacenet
US 12351611 B22025-07-0872O60733Espacenet
US 12351611 B22025-07-0875O60733Espacenet
JP 2025517969 A2025-06-125740O60733Espacenet
US 12091437 B22024-09-1772O60733Espacenet
US 12091437 B22024-09-1775O60733Espacenet

1 to 10 of 64

See all 64 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,463

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLA2G6 papersNewest fiscal year
P30DK056341Washington University Nutrition Obesity Research Center302025
P30DK020579Diabetes Research Center142025
P30CA008748Cancer Center Support Grant82025
P30CA016086Cancer Center Support Grant72025
R01NS076511Lipid Imaging in Traumatic Brain Injury by High Resolution GCIB-secondary Ion Mass Spectrometry72025
R35GM139641Action of Lipolytic Enzymes72025
P30DK079626UAB Diabetes Research Center52025
ZIAHG000215Human Biochemical Genetics52025
P30AG066530Alzheimer's Disease Research Centers42025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)42025

1 to 10 of 1,463Source NIH's project files

See all 1,463 nih grants

Papers2,402

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical, Neuroimaging, and Molecular Characterization of a Juvenile PLAN-like Phenotype in Two Siblings Carrying p.Arg645Gln and an Unresolved Exon 4-7 Copy-Number Gain: A Case Report.Genes (Basel)202642793026PubTator, text miningPubMed
Placental trophoblasts exhibit iron dysregulation and ferroptosis signaling associated with SARS-CoV-2 restriction.Cell Rep202642784456PubTator, text miningPubMed
Camphorquinone-induced phospholipase A2 and cyclooxygenase -2 expression and its roles in 8-isoprostane and prostaglandin E2 production of human dental pulp cells.J Dent Sci202642688640PubTator, text miningPubMed
Regression, Ataxia, and Nystagmus in a Toddler: Unraveling a Rare Neurodegenerative Disorder.Clin Case Rep202642571118PubTator, text miningPubMed
A Case Report: Diagnostic Route of a Patient with PLA2G6-Infantile Neuroaxonal Dystrophy and Familial Hyperlipidemia.Mol Syndromol202642541127PubTator, text miningPubMed
iPLA2β-dependent phospholipid remodeling drives ZIKV-induced neuroinflammation and neurological injury.J Neuroinflammation202642477773PubTator, text miningPubMed
Neurodevelopmental regression Due to PLA2G6-associated neurodegeneration despite normal brain MRI: a case report.Front Pediatr202642453380PubTator, text miningPubMed
Whole-genome sequencing of 197 cases with Parkinson's disease reveals novel pathogenic variants in the Indian population.NPJ Parkinsons Dis202642409815PubTator, text miningPubMed
The Dual Role of Ferroptosis in Cancer: Molecular Mechanisms, Microenvironment Crosstalk, and Precision Therapeutics.Cancers (Basel)202642279414PubTator, text miningPubMed
Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures.Genome Biol202642271430PubTator, text miningPubMed

1 to 10 of 2,402

See all 2,402 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8398

GET https://conductscience.org/api/genes/v1/8398/patents?page=2