Gene · 8399
PLA2G10: phospholipase A2 group X
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PLA2G10: phospholipase A2 group X. Genes, record 8399. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8399
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15496 | Group 10 secretory phospholipase A2 | 165 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents53
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 12608 | O15496 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 10448 | O15496 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7358 | O15496 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7358 | O15496 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 12608 | O15496 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 10448 | O15496 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 10448 | O15496 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7663 | O15496 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7664 | O15496 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 10455 | O15496 | Espacenet |
1 to 10 of 53
See all 53 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| VARESPLADIB METHYL | CHEMBL2105659 | Group X secretory phospholipase A2 inhibitor | INHIBITOR |
Source ChEMBL
Trials4
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT01130246 | VARESPLADIB METHYL | PHASE3 | ClinicalTrials.gov | |
| NCT00743925 | VARESPLADIB METHYL | PHASE2 | ClinicalTrials.gov | |
| NCT00525954 | VARESPLADIB METHYL | PHASE2 | ClinicalTrials.gov | |
| NCT00455546 | VARESPLADIB METHYL | PHASE2 | ClinicalTrials.gov |
NIH grants728
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PLA2G10 papers | Newest fiscal year |
|---|---|---|---|
| K24AI130263 | Immunopathology of Indirect Airway Hyperresponsiveness in Asthma | 4 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 3 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 3 | 2025 |
| T32GM008315 | Mechanisms of Trauma-Induced Coagulopathy | 3 | 2025 |
| K24HL136852 | Mentored Patient-Oriented Research for Preventing ASCVD Events | 2 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 2 | 2025 |
| P30DK020593 | Vanderbilt Diabetes Research Center | 2 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 2 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 2 | 2025 |
| R01GM135158 | Structure and Function of Serum Amyloid A in Health and Disease | 2 | 2025 |
1 to 10 of 728Source NIH's project files
See all 728 nih grantsPapers1,406
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Biological Effects of Secretory Phospholipase A2 from Venoms of Gloydius blomhoffii and Gloydius halys. | Bull Exp Biol Med | 2026 | 42816689 | PubTator, text mining | PubMed |
| Integrated LC-MS and Computer-aided Drug Design Evaluation of Sida cordifolia Herbal Microemulsion Targeting Inflammatory Enzymes through Molecular Docking, MM-GBSA, DFT, and ADMET Profiling. | Curr Comput Aided Drug Des | 2026 | 42786864 | PubTator, text mining | PubMed |
| Secretory Phospholipase A2 in Patients With Sickle Cell Disease Hospitalized for Vaso-Occlusive Pain Episodes. | Pediatr Blood Cancer | 2026 | 42549972 | PubTator, text mining | PubMed |
| sPLA2-reacted extracellular vesicles (SPLEVs) as a therapeutic modality for cytokine storm syndromes. | Sci Adv | 2026 | 42536729 | PubTator, text mining | PubMed |
| A Pseudoenzymatic Regulatory Role of the Noncatalytic Subunit of the Neurotoxin Vipoxin at Arachidonic-Acid-Containing Membrane Interfaces. | Membranes (Basel) | 2026 | 42506206 | PubTator, text mining | PubMed |
Retraction notice to "The molecular structure of secretory phospholipase A2 (sPLA2) and its clinical impact on hepatocellular carcinoma: Regulatory effect of PLA2G12B protein level" [Int. J. Biol. Macromol. 303 (2025) 140663]. | Int J Biol Macromol | 2026 | 42486761 | PubTator, text mining | PubMed |
| [Potent Tissue Protection by Lipid-modified Extracellular Vesicles SPLEVs]. | Yakugaku Zasshi | 2026 | 42091532 | PubTator, text mining | PubMed |
| Oxidized Phosphatidylcholines Regulate Secretory Phospholipase A2 Through Membrane Nanodomain Remodeling. | Molecules | 2026 | 42075976 | PubTator, text mining | PubMed |
| Lessons Learned from a Military-Biotechnology Partnership to Develop a Broad-Spectrum Small-Molecule Inhibitor for Snakebite Envenoming. | Toxins (Basel) | 2026 | 42043044 | PubTator, text mining | PubMed |
| Identification of suicide brain transcriptomic signatures using meta-analysis of multiple cohorts. | Transl Psychiatry | 2026 | 41916959 | PubTator, text mining | PubMed |
1 to 10 of 1,406
See all 1,406 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8399
GET https://conductscience.org/api/genes/v1/8399/patents?page=2