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Gene · 8399

PLA2G10: phospholipase A2 group X

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PLA2G10: phospholipase A2 group X. Genes, record 8399. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8399

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Gene

Symbol
PLA2G10
HGNC
Name
phospholipase A2 group X
HGNC
NCBI Gene ID
8399
NCBI Gene
HGNC ID
HGNC:9029
HGNC
Ensembl
ENSG00000069764
NCBI Gene
Aliases
GXPLA2, GXSPLA2, SPLA2, sPLA2-X
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15496Group 10 secretory phospholipase A21657Ensembl, GeneID, HGNC

Source UniProt

Patents53

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1912608O15496Espacenet
JP 2025147176 A2025-10-0610448O15496Espacenet
JP 2025529142 A2025-09-047358O15496Espacenet
US 12371689 B22025-07-297358O15496Espacenet
JP 2025517970 A2025-06-1212608O15496Espacenet
JP 2025028160 A2025-02-2810448O15496Espacenet
KR 1020250010750 A2025-01-2110448O15496Espacenet
JP 2024123008 A2024-09-107663O15496Espacenet
JP 2024123008 A2024-09-107664O15496Espacenet
JP 2024109657 A2024-08-1410455O15496Espacenet

1 to 10 of 53

See all 53 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
VARESPLADIB METHYLCHEMBL2105659Group X secretory phospholipase A2 inhibitorINHIBITOR

Source ChEMBL

Trials4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01130246VARESPLADIB METHYLPHASE3ClinicalTrials.gov
NCT00743925VARESPLADIB METHYLPHASE2ClinicalTrials.gov
NCT00525954VARESPLADIB METHYLPHASE2ClinicalTrials.gov
NCT00455546VARESPLADIB METHYLPHASE2ClinicalTrials.gov

NIH grants728

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLA2G10 papersNewest fiscal year
K24AI130263Immunopathology of Indirect Airway Hyperresponsiveness in Asthma42025
P30CA016520Abramson Cancer Center Support Grant32025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital32025
T32GM008315Mechanisms of Trauma-Induced Coagulopathy32025
K24HL136852Mentored Patient-Oriented Research for Preventing ASCVD Events22025
P30CA015704Cancer Center Support Grant22025
P30DK020593Vanderbilt Diabetes Research Center22025
P30DK063491Diabetes Research Center (DRC)22025
P30ES013508Center of Excellence in Environmental Toxicology22025
R01GM135158Structure and Function of Serum Amyloid A in Health and Disease22025

1 to 10 of 728Source NIH's project files

See all 728 nih grants

Papers1,406

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Biological Effects of Secretory Phospholipase A2 from Venoms of Gloydius blomhoffii and Gloydius halys.Bull Exp Biol Med202642816689PubTator, text miningPubMed
Integrated LC-MS and Computer-aided Drug Design Evaluation of Sida cordifolia Herbal Microemulsion Targeting Inflammatory Enzymes through Molecular Docking, MM-GBSA, DFT, and ADMET Profiling.Curr Comput Aided Drug Des202642786864PubTator, text miningPubMed
Secretory Phospholipase A2 in Patients With Sickle Cell Disease Hospitalized for Vaso-Occlusive Pain Episodes.Pediatr Blood Cancer202642549972PubTator, text miningPubMed
sPLA2-reacted extracellular vesicles (SPLEVs) as a therapeutic modality for cytokine storm syndromes.Sci Adv202642536729PubTator, text miningPubMed
A Pseudoenzymatic Regulatory Role of the Noncatalytic Subunit of the Neurotoxin Vipoxin at Arachidonic-Acid-Containing Membrane Interfaces.Membranes (Basel)202642506206PubTator, text miningPubMed
Retraction notice to "The molecular structure of secretory phospholipase A2 (sPLA2) and its clinical impact on hepatocellular carcinoma: Regulatory effect of PLA2G12B protein level" [Int. J. Biol. Macromol. 303 (2025) 140663].
Int J Biol Macromol202642486761PubTator, text miningPubMed
[Potent Tissue Protection by Lipid-modified Extracellular Vesicles SPLEVs].Yakugaku Zasshi202642091532PubTator, text miningPubMed
Oxidized Phosphatidylcholines Regulate Secretory Phospholipase A2 Through Membrane Nanodomain Remodeling.Molecules202642075976PubTator, text miningPubMed
Lessons Learned from a Military-Biotechnology Partnership to Develop a Broad-Spectrum Small-Molecule Inhibitor for Snakebite Envenoming.Toxins (Basel)202642043044PubTator, text miningPubMed
Identification of suicide brain transcriptomic signatures using meta-analysis of multiple cohorts.Transl Psychiatry202641916959PubTator, text miningPubMed

1 to 10 of 1,406

See all 1,406 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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