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Gene · 8405

SPOP: speckle type BTB/POZ protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SPOP: speckle type BTB/POZ protein. Genes, record 8405. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8405

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Gene

Symbol
SPOP
HGNC
Name
speckle type BTB/POZ protein
HGNC
NCBI Gene ID
8405
NCBI Gene
HGNC ID
HGNC:11254
HGNC
Ensembl
ENSG00000121067
NCBI Gene
Aliases
BTBD32, NEDMACE, NEDMIDF, NSDVS1, NSDVS2, TEF2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43791Speckle-type POZ protein37436Ensembl, GeneID, HGNC

Source UniProt

Patents111

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025244125 A2025-11-2727O43791Espacenet
EP 4650780 A22025-11-191023O43791Espacenet
EP 4641201 A22025-10-29710O43791Espacenet
JP 2025517969 A2025-06-12710O43791Espacenet
JP 2025517970 A2025-06-121023O43791Espacenet
WO 2025101862 A12025-05-1533O43791Espacenet
EP 4509607 A22025-02-19109O43791Espacenet
JP 2024178154 A2024-12-24109O43791Espacenet
US 11459613 B22022-10-0446O43791Espacenet
KR 1020220127513 A2022-09-201O43791Espacenet

1 to 10 of 111

See all 111 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,321

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSPOP papersNewest fiscal year
P30CA008748Cancer Center Support Grant582025
P50CA097186The Pacific Northwest Prostate Cancer SPORE402025
P30CA016672Cancer Center Support Grant232025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer222025
P30CA006973Regional Oncology Research Center212025
P50CA186786Michigan Prostate SPORE 2025-2030202025
P50CA092629SPORE in Prostate Cancer182025
P30CA015704Cancer Center Support Grant152025
R01CA193837Role of ETS factors in specifying prostate luminal cell identity and androgen receptor dependence112025
P30CA021765Cancer Center Support Grant (CCSG)92025

1 to 10 of 1,321Source NIH's project files

See all 1,321 nih grants

Papers2,215

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Association of ATM Alterations with Outcomes After 177Lu-PSMA-617 Treatment in Patients with Metastatic Castration-Resistant Prostate Cancer.J Nucl Med202642785951PubTator, text miningPubMed
SPOP-mediated ZMYND8 ubiquitination and phase separation exclusion drives mTOR inhibitor resistance in kidney cancer.Nat Commun202642778578PubTator, text miningPubMed
Genomic and transcriptomic correlates of deep prostate-specific antigen response in patients with metastatic androgen pathway modulation-sensitive prostate cancer.Oncologist202642752828PubTator, text miningPubMed
Intratumoral Human Papillomavirus in Advanced Prostate Cancer: Systematic Review, Meta-Analysis, and Real-World Evidence from the Largest Cohort to Date.Int J Mol Sci202642737728PubTator, text miningPubMed
Erratum: The RNA helicase DDX17 enhances androgen receptor stability by interacting with the E3 ubiquitin ligase SPOP in prostate cancer.Transl Androl Urol202642729183PubTator, text miningPubMed
IL-23 promotes PD-L1 expression and tumor immune evasion via METTL16 pathway.Am J Cancer Res202642724552PubTator, text miningPubMed
Association between smoking, tumor genetics, and outcomes in men with metastatic prostate cancer.Prostate Cancer Prostatic Dis202642697914PubTator, text miningPubMed
Proteo-genomics-guided interpretation of somatic mutations in cancer genomes.Cancer Cell202642628524PubTator, text miningPubMed
Double donut versus filament: How structural shapes regulate SPOP activity and cancer pathogenesis.Mol Cell202642561922PubTator, text miningPubMed
Early-Onset Prostate Cancer: Epidemiology, Risk Factors, Biology, Clinical Features, Management, and Early Detection.MedComm (2020)202642488705PubTator, text miningPubMed

1 to 10 of 2,215

See all 2,215 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8405

GET https://conductscience.org/api/genes/v1/8405/patents?page=2