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ULK1: unc-51 like autophagy activating kinase 1

1 protein, 12 patents, 0 drugs, 0 trials, 3,938 NIH grants and 9,890 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolULK1HGNC
Nameunc-51 like autophagy activating kinase 1HGNC
NCBI Gene ID8408NCBI Gene
HGNC IDHGNC:12558HGNC
EnsemblENSG00000177169NCBI Gene
AliasesATG1, ATG1A, UNC51, Unc51.1, hATG1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O75385Serine/threonine-protein kinase ULK11,05018Ensembl, GeneID, HGNCUniProt

Patents 12

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469292O75385Espacenet
EP 4650780 A22025-11-195558O75385Espacenet
EP 4641201 A22025-10-295184O75385Espacenet
JP 2025517969 A2025-06-125184O75385Espacenet
JP 2025517970 A2025-06-125558O75385Espacenet
US 11446398 B22022-09-2095725O75385Espacenet
JP 2022524081 A2022-04-27198696O75385Espacenet
JP 2020536513 A2020-12-176O75385Espacenet
JP 2019054813 A2019-04-11249727O75385Espacenet
WO 2019070638 A12019-04-112O75385Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3938

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant312,025NIH's project files
R35GM131919The mechanism and regulation of autophagy272,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes242,025NIH's project files
P20GM121176Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.192,025NIH's project files
P30CA008748Cancer Center Support Grant182,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)182,025NIH's project files
R37AI042999Pattern Recognition Receptors and Autophagy in Mtb Control in AIDS172,025NIH's project files
P40OD010440Caenorhabditis Genetics Center152,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program142,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center142,025NIH's project files

Papers 9890

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42817119PubTator, text miningPubMed
42817098PubTator, text miningPubMed
42816627PubTator, text miningPubMed
42815263PubTator, text miningPubMed
42812057PubTator, text miningPubMed
42810055PubTator, text miningPubMed
42803943PubTator, text miningPubMed
42787402PubTator, text miningPubMed
42785625PubTator, text miningPubMed
42768744PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license