ConductScience.org, home

Library / Genes

CASP8: caspase 8

1 protein, 124 patents, 2 drugs, 14 trials, 11,078 NIH grants and 36,248 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCASP8HGNC
Namecaspase 8HGNC
NCBI Gene ID841NCBI Gene
HGNC IDHGNC:1509HGNC
EnsemblENSG00000064012NCBI Gene
AliasesALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q14790Caspase-847936Ensembl, GeneID, HGNCUniProt

Patents 124

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026128487 A12026-06-18274Q14790Espacenet
US 12539325 B22026-02-0325Q14790Espacenet
JP 2026000906 A2026-01-0652Q14790Espacenet
EP 4650780 A22025-11-1913759Q14790Espacenet
JP 2025537284 A2025-11-14274Q14790Espacenet
EP 4641201 A22025-10-2915894Q14790Espacenet
JP 2025161810 A2025-10-2422Q14790Espacenet
JP 2025147176 A2025-10-0616529Q14790Espacenet
JP 2025517969 A2025-06-1215894Q14790Espacenet
JP 2025517970 A2025-06-1213759Q14790Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EMRICASANCHEMBL197672Caspase inhibitorINHIBITORChEMBL
NIVOCASANCHEMBL2105721Caspase-8 inhibitorINHIBITORChEMBL

Trials 14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04803227EMRICASANPHASE1ClinicalTrials.gov
NCT03205345EMRICASANPHASE2ClinicalTrials.gov
NCT02686762EMRICASANPHASE2ClinicalTrials.gov
NCT02230683EMRICASANPHASE22016-12-21ClinicalTrials.gov
NCT02230670EMRICASANPHASE22017-07-05ClinicalTrials.gov
NCT02138253EMRICASANPHASE22019-12-11ClinicalTrials.gov
NCT02077374EMRICASANPHASE22016-07-21ClinicalTrials.gov
NCT01937130EMRICASANPHASE22016-04-11ClinicalTrials.gov
NCT01912404EMRICASANPHASE22016-11-04ClinicalTrials.gov
NCT01653899EMRICASANPHASE1/PHASE2ClinicalTrials.gov

NIH grants 11078

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1912,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)622,025NIH's project files
P30CA008748Cancer Center Support Grant582,025NIH's project files
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation532,025NIH's project files
R01AI124346Innate immune signaling and stress response522,025NIH's project files
P30CA047904Cancer Center Support Grant512,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant372,025NIH's project files
P30CA016058Cancer Center Support Grant342,025NIH's project files
R35CA253095Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer342,025NIH's project files
P01CA155258Integrative Oncogenomics of Multiple Myeloma302,025NIH's project files

Papers 36248

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826809PubTator, text miningPubMed
42808676PubTator, text miningPubMed
42808385PubTator, text miningPubMed
42807813PubTator, text miningPubMed
42797376PubTator, text miningPubMed
42797298PubTator, text miningPubMed
42791244PubTator, text miningPubMed
42786987PubTator, text miningPubMed
42774323PubTator, text miningPubMed
42772652PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license