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CASP9: caspase 9

1 protein, 93 patents, 2 drugs, 14 trials, 8,928 NIH grants and 41,082 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCASP9HGNC
Namecaspase 9HGNC
NCBI Gene ID842NCBI Gene
HGNC IDHGNC:1511HGNC
EnsemblENSG00000132906NCBI Gene
AliasesAPAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P55211Caspase-941611Ensembl, GeneID, HGNCUniProt

Patents 93

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4774398 A12026-07-1554P55211Espacenet
WO 2026128487 A12026-06-18278P55211Espacenet
US 12539325 B22026-02-0326P55211Espacenet
JP 2026000906 A2026-01-0680P55211Espacenet
JP 2025537284 A2025-11-14278P55211Espacenet
JP 2025147176 A2025-10-0616527P55211Espacenet
JP 2025062604 A2025-04-1412309P55211Espacenet
WO 2025059385 A22025-03-20213P55211Espacenet
JP 2025032204 A2025-03-1125837P55211Espacenet
JP 2025028160 A2025-02-2816527P55211Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EMRICASANCHEMBL197672Caspase inhibitorINHIBITORChEMBL
NIVOCASANCHEMBL2105721Caspase-9 inhibitorINHIBITORChEMBL

Trials 14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04803227EMRICASANPHASE1ClinicalTrials.gov
NCT03205345EMRICASANPHASE2ClinicalTrials.gov
NCT02686762EMRICASANPHASE2ClinicalTrials.gov
NCT02230683EMRICASANPHASE22016-12-21ClinicalTrials.gov
NCT02230670EMRICASANPHASE22017-07-05ClinicalTrials.gov
NCT02138253EMRICASANPHASE22019-12-11ClinicalTrials.gov
NCT02077374EMRICASANPHASE22016-07-21ClinicalTrials.gov
NCT01937130EMRICASANPHASE22016-04-11ClinicalTrials.gov
NCT01912404EMRICASANPHASE22016-11-04ClinicalTrials.gov
NCT01653899EMRICASANPHASE1/PHASE2ClinicalTrials.gov

NIH grants 8928

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2012,025NIH's project files
P30CA008748Cancer Center Support Grant592,025NIH's project files
P30CA047904Cancer Center Support Grant392,025NIH's project files
P50CA126752SPORE in Lymphoma392,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant322,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant302,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)262,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028252,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT242,025NIH's project files
P01CA155258Integrative Oncogenomics of Multiple Myeloma222,025NIH's project files

Papers 41082

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819741PubTator, text miningPubMed
42812828PubTator, text miningPubMed
42812611PubTator, text miningPubMed
42807991PubTator, text miningPubMed
42807813PubTator, text miningPubMed
42806296PubTator, text miningPubMed
42799649PubTator, text miningPubMed
42798740PubTator, text miningPubMed
42797376PubTator, text miningPubMed
42796408PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license