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Gene · 843

CASP10: caspase 10

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CASP10: caspase 10. Genes, record 843. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/843

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Gene

Symbol
CASP10
HGNC
Name
caspase 10
HGNC
NCBI Gene ID
843
NCBI Gene
HGNC ID
HGNC:1500
HGNC
Ensembl
ENSG00000003400
NCBI Gene
Aliases
ALPS2, FLICE-2, FLICE2, MCH4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92851Caspase-105210Ensembl, GeneID, HGNC

Source UniProt

Patents79

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0327Q92851Espacenet
EP 4650780 A22025-11-192836Q92851Espacenet
EP 4641201 A22025-10-292405Q92851Espacenet
JP 2025147176 A2025-10-0616530Q92851Espacenet
JP 2025517969 A2025-06-122405Q92851Espacenet
JP 2025517970 A2025-06-122836Q92851Espacenet
JP 2025062604 A2025-04-1412230Q92851Espacenet
JP 2025028160 A2025-02-2816530Q92851Espacenet
KR 1020250010750 A2025-01-2116530Q92851Espacenet
US 12133879 B22024-11-0527Q92851Espacenet

1 to 10 of 79

See all 79 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
EMRICASANCHEMBL197672Caspase inhibitorINHIBITOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04803227EMRICASANPHASE1ClinicalTrials.gov
NCT03205345EMRICASANPHASE2ClinicalTrials.gov
NCT02686762EMRICASANPHASE2ClinicalTrials.gov
NCT02230683EMRICASANPHASE22016-12-21ClinicalTrials.gov
NCT02230670EMRICASANPHASE22017-07-05ClinicalTrials.gov
NCT02138253EMRICASANPHASE22019-12-11ClinicalTrials.gov
NCT02077374EMRICASANPHASE22016-07-21ClinicalTrials.gov
NCT01937130EMRICASANPHASE22016-04-11ClinicalTrials.gov
NCT01912404EMRICASANPHASE22016-11-04ClinicalTrials.gov
NCT01653899EMRICASANPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants1,520

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCASP10 papersNewest fiscal year
R01GM100482Center for Critical Assessment of Structure Prediction (CASP)152025
ZIAAI000732Clinical, Immunological and Genetic Analyses of ALPS and Related Immunedysregulatory Disorders132025
P30CA016672Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant82025
P30CA021765Cancer Center Support Grant (CCSG)72025
R01AI124346Innate immune signaling and stress response72025
ZIAAI000717Molecular Mechanisms and Treatment Of Autoimmunity In Humans And Animal Models62025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures62025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation52025
R01AI160179Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases42025

1 to 10 of 1,520Source NIH's project files

See all 1,520 nih grants

Papers2,703

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Association of CASP10 rs13006529 with response to PEG-IFN-α-based therapy in chronic hepatitis B: Enhanced activity of caspase in HBV burden.Biochem Biophys Res Commun202642623843PubTator, text miningPubMed
Could we discuss the molecular signature of immune dysregulation?Clin Exp Immunol202642400499PubTator, text miningPubMed
Soluble CD95L triggers Caspase-10-driven reactive oxygen species production in neutrophils and aggravates anti-neutrophil cytoplasmic antibody-vasculitis.Nat Commun202642321206PubTator, text miningPubMed
Selective HDAC6 inhibition perturbs autophagy and enhances integrated stress response-mediated immunogenic apoptosis in chronic myeloid leukemia.Biomed Pharmacother202642284888PubTator, text miningPubMed
GWAS Meta-analysis Identifies Novel Associated Loci and Points to Causal Tissues in Central Serous Chorioretinopathy.medRxiv202642238393PubTator, text miningPubMed
In Vitro Effects of Amygdalin on Proliferation and Apoptosis in SH-SY5Y Neuroblastoma Cells.Curr Issues Mol Biol202642193125PubTator, text miningPubMed
Transcriptomic and bioinformatics analysis reveals the host response feature and potential treatment strategy of patients with dengue fever.Front Immunol202642148122PubTator, text miningPubMed
LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal integrity via phosphorylation within its lipid-sensing ALPS2 motif.Front Mol Neurosci202642094986PubTator, text miningPubMed
Molecular subtyping of small-cell lung cancer in clinical practice: Primary tumor-lymph node concordance, intratumoral heterogeneity, and genomic context in a Chinese cohort.Lung Cancer202641887131PubTator, text miningPubMed
Chicken caspase-3 promotes IBDV replication via the cleavage of IRF7.Front Microbiol202641809602PubTator, text miningPubMed

1 to 10 of 2,703

See all 2,703 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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