Gene · 843
CASP10: caspase 10
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CASP10: caspase 10. Genes, record 843. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/843
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q92851 | Caspase-10 | 521 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents79
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12539325 B2 | 2026-02-03 | 27 | Q92851 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2836 | Q92851 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2405 | Q92851 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16530 | Q92851 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2405 | Q92851 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2836 | Q92851 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 12230 | Q92851 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 16530 | Q92851 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 16530 | Q92851 | Espacenet |
| US 12133879 B2 | 2024-11-05 | 27 | Q92851 | Espacenet |
1 to 10 of 79
See all 79 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| EMRICASAN | CHEMBL197672 | Caspase inhibitor | INHIBITOR |
Source ChEMBL
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04803227 | EMRICASAN | PHASE1 | ClinicalTrials.gov | |
| NCT03205345 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02686762 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02230683 | EMRICASAN | PHASE2 | 2016-12-21 | ClinicalTrials.gov |
| NCT02230670 | EMRICASAN | PHASE2 | 2017-07-05 | ClinicalTrials.gov |
| NCT02138253 | EMRICASAN | PHASE2 | 2019-12-11 | ClinicalTrials.gov |
| NCT02077374 | EMRICASAN | PHASE2 | 2016-07-21 | ClinicalTrials.gov |
| NCT01937130 | EMRICASAN | PHASE2 | 2016-04-11 | ClinicalTrials.gov |
| NCT01912404 | EMRICASAN | PHASE2 | 2016-11-04 | ClinicalTrials.gov |
| NCT01653899 | EMRICASAN | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants1,520
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CASP10 papers | Newest fiscal year |
|---|---|---|---|
| R01GM100482 | Center for Critical Assessment of Structure Prediction (CASP) | 15 | 2025 |
| ZIAAI000732 | Clinical, Immunological and Genetic Analyses of ALPS and Related Immunedysregulatory Disorders | 13 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 7 | 2025 |
| R01AI124346 | Innate immune signaling and stress response | 7 | 2025 |
| ZIAAI000717 | Molecular Mechanisms and Treatment Of Autoimmunity In Humans And Animal Models | 6 | 2025 |
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 6 | 2025 |
| R37AI101935 | Inflammatory Caspases in Innate Immunity and Inflammation | 5 | 2025 |
| R01AI160179 | Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases | 4 | 2025 |
1 to 10 of 1,520Source NIH's project files
See all 1,520 nih grantsPapers2,703
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Association of CASP10 rs13006529 with response to PEG-IFN-α-based therapy in chronic hepatitis B: Enhanced activity of caspase in HBV burden. | Biochem Biophys Res Commun | 2026 | 42623843 | PubTator, text mining | PubMed |
| Could we discuss the molecular signature of immune dysregulation? | Clin Exp Immunol | 2026 | 42400499 | PubTator, text mining | PubMed |
| Soluble CD95L triggers Caspase-10-driven reactive oxygen species production in neutrophils and aggravates anti-neutrophil cytoplasmic antibody-vasculitis. | Nat Commun | 2026 | 42321206 | PubTator, text mining | PubMed |
| Selective HDAC6 inhibition perturbs autophagy and enhances integrated stress response-mediated immunogenic apoptosis in chronic myeloid leukemia. | Biomed Pharmacother | 2026 | 42284888 | PubTator, text mining | PubMed |
| GWAS Meta-analysis Identifies Novel Associated Loci and Points to Causal Tissues in Central Serous Chorioretinopathy. | medRxiv | 2026 | 42238393 | PubTator, text mining | PubMed |
| In Vitro Effects of Amygdalin on Proliferation and Apoptosis in SH-SY5Y Neuroblastoma Cells. | Curr Issues Mol Biol | 2026 | 42193125 | PubTator, text mining | PubMed |
| Transcriptomic and bioinformatics analysis reveals the host response feature and potential treatment strategy of patients with dengue fever. | Front Immunol | 2026 | 42148122 | PubTator, text mining | PubMed |
| LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal integrity via phosphorylation within its lipid-sensing ALPS2 motif. | Front Mol Neurosci | 2026 | 42094986 | PubTator, text mining | PubMed |
| Molecular subtyping of small-cell lung cancer in clinical practice: Primary tumor-lymph node concordance, intratumoral heterogeneity, and genomic context in a Chinese cohort. | Lung Cancer | 2026 | 41887131 | PubTator, text mining | PubMed |
| Chicken caspase-3 promotes IBDV replication via the cleavage of IRF7. | Front Microbiol | 2026 | 41809602 | PubTator, text mining | PubMed |
1 to 10 of 2,703
See all 2,703 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/843
GET https://conductscience.org/api/genes/v1/843/patents?page=2