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Gene · 84335

AKT1S1: AKT1 substrate 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AKT1S1: AKT1 substrate 1. Genes, record 84335. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/84335

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Gene

Symbol
AKT1S1
HGNC
Name
AKT1 substrate 1
HGNC
NCBI Gene ID
84335
NCBI Gene
HGNC ID
HGNC:28426
HGNC
Ensembl
ENSG00000204673
NCBI Gene
Aliases
Lobe, MGC2865, PRAS40
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96B36Proline-rich AKT1 substrate 12564Ensembl, GeneID, HGNC

Source UniProt

Patents54

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025199077 A12025-09-25160Q96B36Espacenet
JP 2025062604 A2025-04-143698Q96B36Espacenet
JP 2025062604 A2025-04-143700Q96B36Espacenet
JP 2025062604 A2025-04-143701Q96B36Espacenet
JP 2025062604 A2025-04-143702Q96B36Espacenet
JP 2025062604 A2025-04-143703Q96B36Espacenet
US 11564998 B22023-01-315767Q96B36Espacenet
US 11564998 B22023-01-316758Q96B36Espacenet
US 11564998 B22023-01-316759Q96B36Espacenet
US 11564998 B22023-01-316760Q96B36Espacenet

1 to 10 of 54

See all 54 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,112

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAKT1S1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant572025
P30CA008748Cancer Center Support Grant472025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes202025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center142025
P30CA068485Cancer Center Support Grant82025
P30DK020572Michigan Diabetes Research Center (MDRC)82025
P50CA097257Brain Tumor SPORE Grant82025
P30CA016056Roswell Park Cancer Center Support Grant72025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant72025
P50CA092629SPORE in Prostate Cancer72025

1 to 10 of 2,112Source NIH's project files

See all 2,112 nih grants

Papers2,881

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Rutaecarpine suppresses osteosarcoma progression and tumor-induced bone destruction by targeting the PRAS40-associated signaling network in an ex vivo metastasis model.Biochim Biophys Acta Mol Basis Dis202742679911PubTator, text miningPubMed
Targeting PIM kinases in cancer and inflammatory disorders: From mechanisms to clinical translation.Eur J Med Chem202642822254PubTator, text miningPubMed
Single-cell and bulk transcriptomic integration identifies a high-CNV, dark-zone-enriched malignant cell state associated with adverse prognosis in GCB-DLBCL.Hematology202642803950PubTator, text miningPubMed
Brain region-resolved pharmacodynamics of an antisense oligonucleotide targeting human SNCA 3'UTR in BAC-hSNCA rats.Transl Neurodegener202642750047PubTator, text miningPubMed
Reprogramming-driven Proteomic Shifts Mirror Bladder Cancer Progression and Reveal Biomarker Candidates Across Disease Grades.Cancer Genomics Proteomics202642373219PubTator, text miningPubMed
Differential DNA methylation in blood as potential mediator of the association between ambient PM2.5 and cerebrospinal fluid biomarkers of Alzheimer's disease among a cognitively normal population-based cohort.
Mol Psychiatry202642270761PubTator, text miningPubMed
Identification of suicide brain transcriptomic signatures using meta-analysis of multiple cohorts.Transl Psychiatry202641916959PubTator, text miningPubMed
Evolutionary Restructuring and Systematic Review of the NBPF Gene Family: Comparative Genomics, Functional Divergence, and Disease-Linked Pathways.J Dev Biol202641892808PubTator, text miningPubMed
The METTL3 inhibitor STM2457 suppresses gastric cancer progression by modulating m6A RNA modification.PLoS One202641875089PubTator, text miningPubMed
PRAS40 activates the IRE1α-XBP-1-mediated unfolded protein response to exacerbate colorectal cancer by enhancing ST6Gal1-dependent α-2, 6 sialylation of GRP78.Neoplasia202641865639PubTator, text miningPubMed

1 to 10 of 2,881

See all 2,881 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/84335

GET https://conductscience.org/api/genes/v1/84335/patents?page=2