Gene · 84335
AKT1S1: AKT1 substrate 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. AKT1S1: AKT1 substrate 1. Genes, record 84335. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/84335
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96B36 | Proline-rich AKT1 substrate 1 | 256 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents54
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2025199077 A1 | 2025-09-25 | 160 | Q96B36 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3698 | Q96B36 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3700 | Q96B36 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3701 | Q96B36 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3702 | Q96B36 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3703 | Q96B36 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5767 | Q96B36 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 6758 | Q96B36 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 6759 | Q96B36 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 6760 | Q96B36 | Espacenet |
1 to 10 of 54
See all 54 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,112
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | AKT1S1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 57 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 47 | 2025 |
| P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 20 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 14 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 8 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 8 | 2025 |
| P50CA097257 | Brain Tumor SPORE Grant | 8 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 7 | 2025 |
| P30CA138313 | Medical University of South Carolina - Cancer Center Support Grant | 7 | 2025 |
| P50CA092629 | SPORE in Prostate Cancer | 7 | 2025 |
1 to 10 of 2,112Source NIH's project files
See all 2,112 nih grantsPapers2,881
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Rutaecarpine suppresses osteosarcoma progression and tumor-induced bone destruction by targeting the PRAS40-associated signaling network in an ex vivo metastasis model. | Biochim Biophys Acta Mol Basis Dis | 2027 | 42679911 | PubTator, text mining | PubMed |
| Targeting PIM kinases in cancer and inflammatory disorders: From mechanisms to clinical translation. | Eur J Med Chem | 2026 | 42822254 | PubTator, text mining | PubMed |
| Single-cell and bulk transcriptomic integration identifies a high-CNV, dark-zone-enriched malignant cell state associated with adverse prognosis in GCB-DLBCL. | Hematology | 2026 | 42803950 | PubTator, text mining | PubMed |
| Brain region-resolved pharmacodynamics of an antisense oligonucleotide targeting human SNCA 3'UTR in BAC-hSNCA rats. | Transl Neurodegener | 2026 | 42750047 | PubTator, text mining | PubMed |
| Reprogramming-driven Proteomic Shifts Mirror Bladder Cancer Progression and Reveal Biomarker Candidates Across Disease Grades. | Cancer Genomics Proteomics | 2026 | 42373219 | PubTator, text mining | PubMed |
Differential DNA methylation in blood as potential mediator of the association between ambient PM2.5 and cerebrospinal fluid biomarkers of Alzheimer's disease among a cognitively normal population-based cohort. | Mol Psychiatry | 2026 | 42270761 | PubTator, text mining | PubMed |
| Identification of suicide brain transcriptomic signatures using meta-analysis of multiple cohorts. | Transl Psychiatry | 2026 | 41916959 | PubTator, text mining | PubMed |
| Evolutionary Restructuring and Systematic Review of the NBPF Gene Family: Comparative Genomics, Functional Divergence, and Disease-Linked Pathways. | J Dev Biol | 2026 | 41892808 | PubTator, text mining | PubMed |
| The METTL3 inhibitor STM2457 suppresses gastric cancer progression by modulating m6A RNA modification. | PLoS One | 2026 | 41875089 | PubTator, text mining | PubMed |
| PRAS40 activates the IRE1α-XBP-1-mediated unfolded protein response to exacerbate colorectal cancer by enhancing ST6Gal1-dependent α-2, 6 sialylation of GRP78. | Neoplasia | 2026 | 41865639 | PubTator, text mining | PubMed |
1 to 10 of 2,881
See all 2,881 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/84335
GET https://conductscience.org/api/genes/v1/84335/patents?page=2