Gene · 84444
DOT1L: DOT1 like histone lysine methyltransferase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DOT1L: DOT1 like histone lysine methyltransferase. Genes, record 84444. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/84444
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8TEK3 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 1,537 | 48 | Ensembl, GeneID, HGNC |
Source UniProt
Patents33
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 44213 | Q8TEK3 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1826 | Q8TEK3 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 12195 | Q8TEK3 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5996 | Q8TEK3 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1826 | Q8TEK3 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 12195 | Q8TEK3 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 5996 | Q8TEK3 | Espacenet |
| US 11920164 B2 | 2024-03-05 | 149 | Q8TEK3 | Espacenet |
| US 11860162 B2 | 2024-01-02 | 1191 | Q8TEK3 | Espacenet |
| EP 4223770 A2 | 2023-08-09 | 40 | Q8TEK3 | Espacenet |
1 to 10 of 33
See all 33 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,200
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DOT1L papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 57 | 2025 |
| P01CA066996 | Development of Novel Therapeutic Strategies in Human Leukemias | 26 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 22 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 10 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 10 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 9 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 9 | 2025 |
| P30CA045508 | CSHL Cancer Center Support Grant | 8 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 8 | 2025 |
| R01AI118891 | Viral modulation of epitranscriptomic mechanisms | 8 | 2025 |
1 to 10 of 2,200Source NIH's project files
See all 2,200 nih grantsPapers2,742
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Shared genetic architecture of schizophrenia and lupus identifies pleiotropic loci with distinct downstream mechanisms. | Hum Mol Genet | 2026 | 42822865 | PubTator, text mining | PubMed |
| Targeting the Epigenetic-Immune Axis in Acute Myeloid Leukemia: Current Advances and Future Directions. | Curr Oncol Rep | 2026 | 42809184 | PubTator, text mining | PubMed |
| Erratum: DOT1L promotes cell proliferation and invasion by epigenetically regulating STAT5B in renal cell carcinoma. | Am J Cancer Res | 2026 | 42724530 | PubTator, text mining | PubMed |
| Correction for Sepulveda et al., Proteolytic activation of c-MYC facilitated by DOT1L. | Proc Natl Acad Sci U S A | 2026 | 42709827 | PubTator, text mining | PubMed |
| Engineered Cyanobacteria-Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy. | Adv Sci (Weinh) | 2026 | 42671032 | PubTator, text mining | PubMed |
| Genome-Wide Identification of a Chromatin-Splicing Regulatory Axis Driven by DOT1L in MLL-Rearranged Acute Myeloid Leukemia. | Genes (Basel) | 2026 | 42650050 | PubTator, text mining | PubMed |
| Targeting DOT1L Epigenetic Moonlighting in MLL-Rearranged Leukemia. | Cells | 2026 | 42587807 | PubTator, text mining | PubMed |
| A Comprehensive Reactive-Oxygen-Species-Scavenging Metal-Organic Framework Orchestrates the AMPK-DOT1L-H3K79me3 Cascade to Alleviate Osteoarthritis. | Biomater Res | 2026 | 42582552 | PubTator, text mining | PubMed |
| Degraders of histone lysine methyltransferases: Progress, challenges, and opportunities. | Drug Discov Today | 2026 | 42542162 | PubTator, text mining | PubMed |
| Targeting senescence-associated secretory phenotype macrophage: apigenin inhibits DOT1L-dependent H3K79me2 at IL1A to fight SASP in senescent macrophages. | Front Mol Biosci | 2026 | 42534541 | PubTator, text mining | PubMed |
1 to 10 of 2,742
See all 2,742 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/84444
GET https://conductscience.org/api/genes/v1/84444/patents?page=2