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Gene · 84444

DOT1L: DOT1 like histone lysine methyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DOT1L: DOT1 like histone lysine methyltransferase. Genes, record 84444. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/84444

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Gene

Symbol
DOT1L
HGNC
Name
DOT1 like histone lysine methyltransferase
HGNC
NCBI Gene ID
84444
NCBI Gene
HGNC ID
HGNC:24948
HGNC
Ensembl
ENSG00000104885
NCBI Gene
Aliases
DOT1, KIAA1814, KMT4, NDNS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8TEK3Histone-lysine N-methyltransferase, H3 lysine-79 specific1,53748Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444213Q8TEK3Espacenet
EP 4640849 A22025-10-291826Q8TEK3Espacenet
EP 4641201 A22025-10-2912195Q8TEK3Espacenet
EP 4641202 A22025-10-295996Q8TEK3Espacenet
JP 2025519096 A2025-06-241826Q8TEK3Espacenet
JP 2025517969 A2025-06-1212195Q8TEK3Espacenet
KR 1020250017231 A2025-02-045996Q8TEK3Espacenet
US 11920164 B22024-03-05149Q8TEK3Espacenet
US 11860162 B22024-01-021191Q8TEK3Espacenet
EP 4223770 A22023-08-0940Q8TEK3Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,200

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDOT1L papersNewest fiscal year
P30CA008748Cancer Center Support Grant572025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias262025
P30CA016672Cancer Center Support Grant222025
P30CA016086Cancer Center Support Grant102025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center102025
P01CA013106Targeting Transcription and Splicing in Cancer92025
P30CA010815Consolidated Basic Cancer Research Program92025
P30CA045508CSHL Cancer Center Support Grant82025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant82025
R01AI118891Viral modulation of epitranscriptomic mechanisms82025

1 to 10 of 2,200Source NIH's project files

See all 2,200 nih grants

Papers2,742

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Shared genetic architecture of schizophrenia and lupus identifies pleiotropic loci with distinct downstream mechanisms.Hum Mol Genet202642822865PubTator, text miningPubMed
Targeting the Epigenetic-Immune Axis in Acute Myeloid Leukemia: Current Advances and Future Directions.Curr Oncol Rep202642809184PubTator, text miningPubMed
Erratum: DOT1L promotes cell proliferation and invasion by epigenetically regulating STAT5B in renal cell carcinoma.Am J Cancer Res202642724530PubTator, text miningPubMed
Correction for Sepulveda et al., Proteolytic activation of c-MYC facilitated by DOT1L.Proc Natl Acad Sci U S A202642709827PubTator, text miningPubMed
Engineered Cyanobacteria-Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy.Adv Sci (Weinh)202642671032PubTator, text miningPubMed
Genome-Wide Identification of a Chromatin-Splicing Regulatory Axis Driven by DOT1L in MLL-Rearranged Acute Myeloid Leukemia.Genes (Basel)202642650050PubTator, text miningPubMed
Targeting DOT1L Epigenetic Moonlighting in MLL-Rearranged Leukemia.Cells202642587807PubTator, text miningPubMed
A Comprehensive Reactive-Oxygen-Species-Scavenging Metal-Organic Framework Orchestrates the AMPK-DOT1L-H3K79me3 Cascade to Alleviate Osteoarthritis.Biomater Res202642582552PubTator, text miningPubMed
Degraders of histone lysine methyltransferases: Progress, challenges, and opportunities.Drug Discov Today202642542162PubTator, text miningPubMed
Targeting senescence-associated secretory phenotype macrophage: apigenin inhibits DOT1L-dependent H3K79me2 at IL1A to fight SASP in senescent macrophages.Front Mol Biosci202642534541PubTator, text miningPubMed

1 to 10 of 2,742

See all 2,742 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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