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Gene · 84447

SYVN1: synoviolin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SYVN1: synoviolin 1. Genes, record 84447. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/84447

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Gene

Symbol
SYVN1
HGNC
Name
synoviolin 1
HGNC
NCBI Gene ID
84447
NCBI Gene
HGNC ID
HGNC:20738
HGNC
Ensembl
ENSG00000162298
NCBI Gene
Aliases
DER3, HRD1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q86TM6E3 ubiquitin-protein ligase synoviolin6177Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1466162Q86TM6Espacenet
EP 4650780 A22025-11-199886Q86TM6Espacenet
JP 2025529142 A2025-09-044564Q86TM6Espacenet
US 12371689 B22025-07-294564Q86TM6Espacenet
JP 2025517970 A2025-06-129886Q86TM6Espacenet
US 11446398 B22022-09-2085873Q86TM6Espacenet
JP 2022524081 A2022-04-27188844Q86TM6Espacenet
JP 2019054813 A2019-04-11246597Q86TM6Espacenet
JP 2017121241 A2017-07-13246597Q86TM6Espacenet
JP 2015516143 A2015-06-08246597Q86TM6Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,028

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSYVN1 papersNewest fiscal year
R01DK120330Novel role of hepatic SEL1L-HRD1 ERAD in bile acid metabolism222025
P30DK020572Michigan Diabetes Research Center (MDRC)172025
P30ES006694Southwest Environmental Health Sciences Center122025
R01GM052586Protein Transport Across Membranes102025
R01DK128077Novel role of endoplasmic reticulum-associated degradation in iron metabolism92025
P30CA016672Cancer Center Support Grant72025
ZIADK033008Mechanism of protein quality control at the endoplasmic reticulum72025
P30DK054759Precision Medicine Center for Cystic Fibrosis62025
P30DK089503Michigan Nutrition Obesity Research Center62025
R35GM128592Protein quality control at eukaryotic membranes62025

1 to 10 of 1,028Source NIH's project files

See all 1,028 nih grants

Papers1,633

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Reanalysis of a published cryo-EM dataset reveals domain-level variability in the Hrd1-Hrd3 complex.Biochem Biophys Res Commun202642826650PubTator, text miningPubMed
SYVN1-mediated succinate accumulation exacerbates heart failure.Sci China Life Sci202642804134PubTator, text miningPubMed
Bardoxolone methyl induces mitochondrial dysfunction, activation of the cytosolic stress response, and increased chaperone capacity in SH-SY5Y cells. Focus on mitochondrial protease LONP1.Gen Physiol Biophys202642717783PubTator, text miningPubMed
Flavokawain B inhibits ER-associated protein dislocation and reduces infectious Zika virus production.Biochem Biophys Res Commun202642679751PubTator, text miningPubMed
E3 ubiquitin ligase SYVN1 promotes the malignant phenotype of A549 cells by upregulating GATA3 expression via NRP1.In Vitro Cell Dev Biol Anim202642613558PubTator, text miningPubMed
ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER-Mitochondria Contact Sites.Adv Sci (Weinh)202642531701PubTator, text miningPubMed
Identification of Clofibric Acid as a Synoviolin (SYVN1) Ligand for Proteolysis-Targeting Chimera (PROTAC) Development.ACS Med Chem Lett202642445038PubTator, text miningPubMed
Beyond KEAP1: The Context-Specific NRF2 Partner Code in Disease and Therapy.Antioxidants (Basel)202642352065PubTator, text miningPubMed
HERPUD1 suppresses porcine epidemic diarrhea virus replication by recruiting HRD1 to degrade viral ORF3 protein.J Virol202642307246PubTator, text miningPubMed
Nanoplastics and Benzo[a]pyrene Co-pollution aggravates pulmonary ferroptosis via endoplasmic reticulum stress-triggered IRE1α liquid-liquid phase separation.Ecotoxicol Environ Saf202642259117PubTator, text miningPubMed

1 to 10 of 1,633

See all 1,633 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/84447

GET https://conductscience.org/api/genes/v1/84447/patents