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Gene · 84464

SLX4: SLX4 structure-specific endonuclease subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLX4: SLX4 structure-specific endonuclease subunit. Genes, record 84464. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/84464

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Gene

Symbol
SLX4
HGNC
Name
SLX4 structure-specific endonuclease subunit
HGNC
NCBI Gene ID
84464
NCBI Gene
HGNC ID
HGNC:23845
HGNC
Ensembl
ENSG00000188827
NCBI Gene
Aliases
BTBD12, FANCP, KIAA1784, KIAA1987, MUS312
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8IY92Structure-specific endonuclease subunit SLX41,8347Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-293134Q8IY92Espacenet
JP 2025517969 A2025-06-123134Q8IY92Espacenet
EP 4464338 A22024-11-20197Q8IY92Espacenet
JP 2024123008 A2024-09-108455Q8IY92Espacenet
US 11976334 B22024-05-07202Q8IY92Espacenet
US 11680268 B22023-06-20197Q8IY92Espacenet
JP 2022141755 A2022-09-29577Q8IY92Espacenet
US 11446398 B22022-09-2079641Q8IY92Espacenet
JP 2022524081 A2022-04-27182612Q8IY92Espacenet
US 11078247 B22021-08-0310655Q8IY92Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,105

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLX4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant272025
P30CA016672Cancer Center Support Grant132025
P01CA092584Structural Cell Biology of DNA Repair Machines122025
ZIAHG000029Fanconi Anemia: Genotype-Phenotype Correlations102025
ZIACP010144Clinical Genetic Studies of Familial and Hereditary Cancer Syndromes92025
R01GM058015Recombinational Mechanisms of DNA Repair72025
ZIAAG000746Repair of localized DNA damage72025
R01HL052725Molecular Pathogenesis of Fanconi Anemia62025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success62025
ZICHG200346NHGRI/DIR Genomics Core62025

1 to 10 of 1,105Source NIH's project files

See all 1,105 nih grants

Papers1,453

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Scutellarin as a specific GEN1 inhibitor synergizes with olaparib to induce synthetic lethality in human tumor cells.Bioorg Chem202642632200PubTator, text miningPubMed
CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency.Nucleic Acids Res202642598853PubTator, text miningPubMed
Fulminant extraneural metastases in MYC-amplified Group 3 medulloblastoma: a pediatric case report.Childs Nerv Syst202642399488PubTator, text miningPubMed
Transcriptomics identifies mild hyperthermia-conditioned tumor supernatant as an inducer of HepG2 transition.Cytotechnology202642358519PubTator, text miningPubMed
CIP2A recruits SLX4-MUS81-XPF in mitosis and protects against replication stress.EMBO Rep202642192029PubTator, text miningPubMed
Phosphorylation by CDK1 switches the function of the human SLX4 SAP domain from DNA binding to MUS81 binding.Nucleic Acids Res202642130070PubTator, text miningPubMed
Genome-Scale CRISPR Screens Reveal DNA Repair Dependencies That Sensitize Hepatocellular Carcinoma to Oxaliplatin.Cancers (Basel)202642122158PubTator, text miningPubMed
Efficacy of olaparib in advanced cancers with somatic or germline mutations in BAP1, BARD1, BRIP1 and PALB2.ESMO Open202642105598PubTator, text miningPubMed
COSA-1-SLX-4 interaction directly links crossover designation with Holliday junction resolution.Sci Adv202642030394PubTator, text miningPubMed
Slx4 and Fun30/SMARCAD1 coordinate S-phase checkpoint regulation and replication fork protection in response to Top1-DNA crosslinks.Nucleic Acids Res202641978269PubTator, text miningPubMed

1 to 10 of 1,453

See all 1,453 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/84464

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