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Gene · 8451

CUL4A: cullin 4A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CUL4A: cullin 4A. Genes, record 8451. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8451

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Gene

Symbol
CUL4A
HGNC
Name
cullin 4A
HGNC
NCBI Gene ID
8451
NCBI Gene
HGNC ID
HGNC:2554
HGNC
Ensembl
ENSG00000139842
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13619Cullin-4A75916Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442553Q13619Espacenet
EP 4650780 A22025-11-199624Q13619Espacenet
EP 4641201 A22025-10-299888Q13619Espacenet
JP 2025517969 A2025-06-129888Q13619Espacenet
JP 2025517970 A2025-06-129624Q13619Espacenet
US 11879000 B22024-01-2314Q13619Espacenet
US 11446398 B22022-09-2020789Q13619Espacenet
JP 2022524081 A2022-04-27123760Q13619Espacenet
US 11078247 B22021-08-032738Q13619Espacenet
WO 2020043864 A12020-03-05606Q13619Espacenet

1 to 10 of 17

See all 17 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IBERDOMIDECHEMBL3989927CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
LENALIDOMIDECHEMBL848CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL
LENALIDOMIDECHEMBL848CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
LENALIDOMIDE HYDROCHLORIDE MONOHYDRATECHEMBL6068337CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
POMALIDOMIDECHEMBL43452CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL
THALIDOMIDECHEMBL468CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL

Trials1,695

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416LENALIDOMIDEPHASE2ClinicalTrials.gov
NCT07601100IBERDOMIDEPHASE1/PHASE2ClinicalTrials.gov
NCT07600151LENALIDOMIDEPHASE1/PHASE2ClinicalTrials.gov
NCT07585747LENALIDOMIDEPHASE2ClinicalTrials.gov
NCT07569757POMALIDOMIDEPHASE3ClinicalTrials.gov
NCT07562022LENALIDOMIDEPHASE3ClinicalTrials.gov
NCT07555938POMALIDOMIDEPHASE3ClinicalTrials.gov
NCT07532525POMALIDOMIDEPHASE1ClinicalTrials.gov
NCT07523737POMALIDOMIDEPHASE2ClinicalTrials.gov
NCT07505849LENALIDOMIDEPHASE2ClinicalTrials.gov

1 to 10 of 1,695

See all 1,695 trials

NIH grants1,323

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCUL4A papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)112025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control112025
P30CA008748Cancer Center Support Grant102025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202882025
P30CA016672Cancer Center Support Grant72025
P01CA155258Integrative Oncogenomics of Multiple Myeloma62025
R35ES031638Watching cooperative interactions between base and nucleotide excision repair proteins62025
T32CA009109Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies62025
P01CA092584Structural Cell Biology of DNA Repair Machines52025
P30CA016058Cancer Center Support Grant52025

1 to 10 of 1,323Source NIH's project files

See all 1,323 nih grants

Papers1,929

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
HBx Downregulates TFEB via the CUL4A/CUL4B-DDB1 Axis to Disrupt Lysosomal Function in Hepatocellular Carcinoma Cells.Cells202642505369PubTator, text miningPubMed
TMEM161B-AS1: a pivotal long non-coding RNA in the pathogenesis of glioblastoma revealed by Mendelian randomization analysis.Int J Clin Exp Pathol202642466213PubTator, text miningPubMed
Identification of exosome-related genes signature based on bioinformatics and machine learning for prognostic prediction in colorectal cancer.Discov Oncol202642400715PubTator, text miningPubMed
TDTAC: a generalized time-dependent torsion angle correlation framework for resolving directional coordination in large biomolecular assemblies.Front Mol Biosci202642311447PubTator, text miningPubMed
Correction to 'Cul4A is an oncogene in malignant pleural mesothelioma'.J Cell Mol Med202642012616PubTator, text miningPubMed
Targeting IP6 signaling to destabilize homologous recombination proteins to overcome PARP inhibitor resistance.Nat Commun202641935081PubTator, text miningPubMed
Stability of c-Myc Protein in Early S Phase Is Regulated by the Interaction with PCNA.Int J Mol Sci202641898606PubTator, text miningPubMed
The Role of A-Kinase Anchoring Proteins for Inhibitory cAMP Signalling in Platelets.Cells202641892342PubTator, text miningPubMed
The JMJD family histone demethylases: structure, mechanism of action, diseases and therapeutic targets.Mol Biomed202641857315PubTator, text miningPubMed
Molecular profiling of breast cancer in native American women reveals distinct genomic and transcriptomic features.NPJ Precis Oncol202641844957PubTator, text miningPubMed

1 to 10 of 1,929

See all 1,929 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8451

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