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CASR: calcium sensing receptor

1 protein, 25 patents, 9 drugs, 84 trials, 2,315 NIH grants and 6,345 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCASRHGNC
Namecalcium sensing receptorHGNC
NCBI Gene ID846NCBI Gene
HGNC IDHGNC:1514HGNC
EnsemblENSG00000036828NCBI Gene
AliasesCAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1, hCasRNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P41180Extracellular calcium-sensing receptor1,07831Ensembl, GeneID, HGNCUniProt

Patents 25

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026168538 A2026-08-134P41180Espacenet
JP 2026004568 A2026-01-1439739P41180Espacenet
JP 2026004568 A2026-01-1439740P41180Espacenet
EP 4650780 A22025-11-1919250P41180Espacenet
EP 4640849 A22025-10-293917P41180Espacenet
EP 4641201 A22025-10-2924344P41180Espacenet
JP 2025529142 A2025-09-04734P41180Espacenet
US 12371689 B22025-07-29734P41180Espacenet
JP 2025519096 A2025-06-243917P41180Espacenet
JP 2025517969 A2025-06-1224344P41180Espacenet

Drugs 9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASP7991CHEMBL3545100Calcium sensing receptor positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CINACALCETCHEMBL1201284Calcium sensing receptor positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
CINACALCET HYDROCHLORIDECHEMBL1200776Calcium sensing receptor positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
ETELCALCETIDECHEMBL3545184Calcium sensing receptor agonistAGONISTChEMBL
ETELCALCETIDE HYDROCHLORIDECHEMBL3545183Calcium sensing receptor agonistAGONISTChEMBL
EVOCALCETCHEMBL4297621Calcium sensing receptor positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
RONACALERETCHEMBL1198855Calcium sensing receptor antagonistANTAGONISTChEMBL
TECALCETCHEMBL292376Calcium sensing receptor modulatorMODULATORChEMBL
TECALCET HYDROCHLORIDECHEMBL2107572Calcium sensing receptor modulatorMODULATORChEMBL

Trials 84

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07122401CINACALCETPHASE3ClinicalTrials.gov
NCT07007338CINACALCETClinicalTrials.gov
NCT06690242ETELCALCETIDE HYDROCHLORIDEPHASE2ClinicalTrials.gov
NCT06288451CINACALCETPHASE2ClinicalTrials.gov
NCT05663411CINACALCETPHASE2ClinicalTrials.gov
NCT04637360CINACALCETClinicalTrials.gov
NCT03969329ETELCALCETIDEPHASE3ClinicalTrials.gov
NCT03960437ETELCALCETIDEPHASE22023-09-21ClinicalTrials.gov
NCT03822507CINACALCET HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT03822507EVOCALCETPHASE3ClinicalTrials.gov

NIH grants 2315

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIADK043012Clinical Investigation of FIHP, Parathyroid Cancer & the HPT-JT Syndrome152,025NIH's project files
IK6BX004835BLRD Research Career Scientist Award Application92,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award92,025NIH's project files
ZIADE000649Skeletal Disorders and Mineral Homeostasis Section92,025NIH's project files
ZIADK043006Hyperparathyroidism -- Etiology, Diagnosis and Treatment82,025NIH's project files
P30DK063491Diabetes Research Center (DRC)72,025NIH's project files
R01NS031373Functions of Metabotropic Glutamate Receptor Subtypes72,025NIH's project files
U01DK108334INSPPIRE: Using the natural history of pediatric chronic pancreatitis to identify disease predictors and design therapies72,025NIH's project files
P30CA016672Cancer Center Support Grant62,025NIH's project files
R01MH062646Regulation of Signaling by mGluR562,025NIH's project files

Papers 6345

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42811434PubTator, text miningPubMed
42787214PubTator, text miningPubMed
42775144PubTator, text miningPubMed
42736679PubTator, text miningPubMed
42731651PubTator, text miningPubMed
42725042PubTator, text miningPubMed
42709961PubTator, text miningPubMed
42705258PubTator, text miningPubMed
42703929PubTator, text miningPubMed
42689986PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license