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HAVCR2: hepatitis A virus cellular receptor 2

1 protein, 312 patents, 3 drugs, 22 trials, 5,610 NIH grants and 17,882 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHAVCR2HGNC
Namehepatitis A virus cellular receptor 2HGNC
NCBI Gene ID84868NCBI Gene
HGNC IDHGNC:18437HGNC
EnsemblENSG00000135077NCBI Gene
AliasesCD366, FLJ14428, HAVcr-2, KIM-3, SPTCL, TIM3, TIMD-3, TIMD3, Tim-3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q8TDQ0Hepatitis A virus cellular receptor 230111Ensembl, GeneID, HGNCUniProt

Patents 312

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4831196 A22026-10-2817Q8TDQ0Espacenet
EP 4806462 A22026-09-1636Q8TDQ0Espacenet
EP 4791793 A12026-08-1996Q8TDQ0Espacenet
US 12624087 B22026-05-1217Q8TDQ0Espacenet
US 12612446 B22026-04-28458Q8TDQ0Espacenet
JP 2026506893 A2026-02-27128Q8TDQ0Espacenet
WO 2025262045 A12025-12-2634Q8TDQ0Espacenet
WO 2025262304 A12025-12-2642Q8TDQ0Espacenet
US 12497458 B22025-12-162Q8TDQ0Espacenet
JP 2025172069 A2025-11-20312Q8TDQ0Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COBOLIMABCHEMBL4298123Hepatitis A virus cellular receptor 2 inhibitorINHIBITORChEMBL
LOMVASTOMIGCHEMBL4594602Hepatitis A virus cellular receptor 2 inhibitorINHIBITORChEMBL
SABATOLIMABCHEMBL4594575Hepatitis A virus cellular receptor 2 inhibitorINHIBITORChEMBL

Trials 22

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06664879SABATOLIMABPHASE1/PHASE2ClinicalTrials.gov
NCT06238635COBOLIMABPHASE2ClinicalTrials.gov
NCT05367401SABATOLIMABPHASE1/PHASE2ClinicalTrials.gov
NCT04878432SABATOLIMABPHASE22025-07-31ClinicalTrials.gov
NCT04823624SABATOLIMABPHASE22026-02-27ClinicalTrials.gov
NCT04812548SABATOLIMABPHASE22024-06-11ClinicalTrials.gov
NCT04810611SABATOLIMABPHASE1ClinicalTrials.gov
NCT04785820LOMVASTOMIGPHASE2ClinicalTrials.gov
NCT04655976COBOLIMABPHASE2/PHASE3ClinicalTrials.gov
NCT04623216SABATOLIMABPHASE1/PHASE22025-06-03ClinicalTrials.gov

NIH grants 5610

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1592,025NIH's project files
P30CA016672Cancer Center Support Grant1272,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award612,025NIH's project files
P30CA047904Cancer Center Support Grant472,025NIH's project files
P30CA006973Regional Oncology Research Center432,025NIH's project files
P01AI039671Costimulatory Mechanisms of Autoimmunity362,025NIH's project files
P30CA016359Cancer Center Support Grant312,025NIH's project files
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy302,025NIH's project files
P51OD011132Emory National Primate Research Center262,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies252,025NIH's project files

Papers 17882

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826489PubTator, text miningPubMed
42825905PubTator, text miningPubMed
42823731PubTator, text miningPubMed
42819567PubTator, text miningPubMed
42816994PubTator, text miningPubMed
42814600PubTator, text miningPubMed
42813315PubTator, text miningPubMed
42812382PubTator, text miningPubMed
42806659PubTator, text miningPubMed
42801723PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license