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Gene · 84876

ORAI1: ORAI calcium release-activated calcium modulator 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ORAI1: ORAI calcium release-activated calcium modulator 1. Genes, record 84876. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/84876

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Gene

Symbol
ORAI1
HGNC
Name
ORAI calcium release-activated calcium modulator 1
HGNC
NCBI Gene ID
84876
NCBI Gene
HGNC ID
HGNC:25896
HGNC
Ensembl
ENSG00000276045
NCBI Gene
Aliases
CRACM1, FLJ14466, IMD9, ORAT1, TAM2, TMEM142A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96D31Calcium release-activated calcium channel protein 13012Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-293768Q96D31Espacenet
EP 4641201 A22025-10-2923303Q96D31Espacenet
JP 2025158948 A2025-10-175Q96D31Espacenet
JP 2025147176 A2025-10-069820Q96D31Espacenet
JP 2025519096 A2025-06-243768Q96D31Espacenet
JP 2025517969 A2025-06-1223303Q96D31Espacenet
JP 2025028160 A2025-02-289820Q96D31Espacenet
KR 1020250010750 A2025-01-219820Q96D31Espacenet
JP 2024109657 A2024-08-149827Q96D31Espacenet
US 11446398 B22022-09-2060230Q96D31Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,777

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleORAI1 papersNewest fiscal year
ZIADE000438Molecular Mechanisms Regulating Calcium Flux In Salivary Glands372025
R01DE017102TRPC1, Calcium, and Saliva Secretion202025
R01AI040127Signal transduction and gene induction in lymphocytes192025
ZIADE000735Ca2+ signaling and HCO3- secretion by exocrine glands192025
R01HL056470Neonatal Modulation of Airway Contractility142025
R35HL150778Ca2+ signaling Networks in Health and Disease132025
P30CA016087Cancer Center Support Grant112025
T32AI007290Molecular and Cellular Immunobiology102025
R01DE019245An experimental/computational approach for understanding salivary fluid secretion92025
ZIAHD000196Phosphoinositide-calcium Signaling In Cell Regulation92025

1 to 10 of 1,777Source NIH's project files

See all 1,777 nih grants

Papers3,783

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The phenotypic heterogeneity of tumor-derived cells in the bloodstream of pancreatic cancer patients.Front Cell Dev Biol202642807419PubTator, text miningPubMed
M184V: The Major Determinant of Cooperative ISL Resistance When in Combination with Multiple TAM2 Mutations in HIV-1 Subtype C.Viruses202642797877PubTator, text miningPubMed
Ginsenoside Compound K Differentially Regulates Neuronal and Astrocytic Ca2+ Homeostasis Under Trimethyltin-Induced Stress.Pharmaceuticals (Basel)202642797422PubTator, text miningPubMed
TH1177, Clemastine, and Benzhydryl Derivatives Act as Novel Extracellular Blockers of ORAI Channels.Biomolecules202642793204PubTator, text miningPubMed
TPC2-mediated lysosomal Ca2+ release puts the brakes on store-operated Ca2+ entry.Cell Calcium202642790318PubTator, text miningPubMed
FGF23 blockade induces maladaptive vascular remodelling, reducing pathologically increased arterial stiffness and blood pressure.Nephrol Dial Transplant202642784441PubTator, text miningPubMed
Targeting the Orai1 CRAC channel: translating molecular insights into therapeutic progress.Expert Opin Ther Targets202642766407PubTator, text miningPubMed
Retraction notice to "Combined diosmin and bisoprolol attenuate cobalt chloride-induced cardiotoxicity and endothelial dysfunction through modulating miR-143-3P/MAPK/MCP-1, ERK5/CXCR4, Orai-1/STIM-1 signaling pathways" [Int. Immunopharmacol. 140 (2024) 112777].
Int Immunopharmacol202642760158PubTator, text miningPubMed
β-carotene alleviates PM2.5-induced pulmonary fibrosis via suppression of the Frizzled5-mediated Wnt5a/Ca2+pathway.Ecotoxicol Environ Saf202642759460PubTator, text miningPubMed
The many faces of Orai1 dysfunction: Molecular mechanisms and clinical manifestations.J Gen Physiol202642671323PubTator, text miningPubMed

1 to 10 of 3,783

See all 3,783 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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