Gene · 84876
ORAI1: ORAI calcium release-activated calcium modulator 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ORAI1: ORAI calcium release-activated calcium modulator 1. Genes, record 84876. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/84876
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96D31 | Calcium release-activated calcium channel protein 1 | 301 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4640849 A2 | 2025-10-29 | 3768 | Q96D31 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 23303 | Q96D31 | Espacenet |
| JP 2025158948 A | 2025-10-17 | 5 | Q96D31 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 9820 | Q96D31 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 3768 | Q96D31 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 23303 | Q96D31 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 9820 | Q96D31 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 9820 | Q96D31 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 9827 | Q96D31 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 60230 | Q96D31 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,777
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ORAI1 papers | Newest fiscal year |
|---|---|---|---|
| ZIADE000438 | Molecular Mechanisms Regulating Calcium Flux In Salivary Glands | 37 | 2025 |
| R01DE017102 | TRPC1, Calcium, and Saliva Secretion | 20 | 2025 |
| R01AI040127 | Signal transduction and gene induction in lymphocytes | 19 | 2025 |
| ZIADE000735 | Ca2+ signaling and HCO3- secretion by exocrine glands | 19 | 2025 |
| R01HL056470 | Neonatal Modulation of Airway Contractility | 14 | 2025 |
| R35HL150778 | Ca2+ signaling Networks in Health and Disease | 13 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 11 | 2025 |
| T32AI007290 | Molecular and Cellular Immunobiology | 10 | 2025 |
| R01DE019245 | An experimental/computational approach for understanding salivary fluid secretion | 9 | 2025 |
| ZIAHD000196 | Phosphoinositide-calcium Signaling In Cell Regulation | 9 | 2025 |
1 to 10 of 1,777Source NIH's project files
See all 1,777 nih grantsPapers3,783
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The phenotypic heterogeneity of tumor-derived cells in the bloodstream of pancreatic cancer patients. | Front Cell Dev Biol | 2026 | 42807419 | PubTator, text mining | PubMed |
| M184V: The Major Determinant of Cooperative ISL Resistance When in Combination with Multiple TAM2 Mutations in HIV-1 Subtype C. | Viruses | 2026 | 42797877 | PubTator, text mining | PubMed |
| Ginsenoside Compound K Differentially Regulates Neuronal and Astrocytic Ca2+ Homeostasis Under Trimethyltin-Induced Stress. | Pharmaceuticals (Basel) | 2026 | 42797422 | PubTator, text mining | PubMed |
| TH1177, Clemastine, and Benzhydryl Derivatives Act as Novel Extracellular Blockers of ORAI Channels. | Biomolecules | 2026 | 42793204 | PubTator, text mining | PubMed |
| TPC2-mediated lysosomal Ca2+ release puts the brakes on store-operated Ca2+ entry. | Cell Calcium | 2026 | 42790318 | PubTator, text mining | PubMed |
| FGF23 blockade induces maladaptive vascular remodelling, reducing pathologically increased arterial stiffness and blood pressure. | Nephrol Dial Transplant | 2026 | 42784441 | PubTator, text mining | PubMed |
| Targeting the Orai1 CRAC channel: translating molecular insights into therapeutic progress. | Expert Opin Ther Targets | 2026 | 42766407 | PubTator, text mining | PubMed |
Retraction notice to "Combined diosmin and bisoprolol attenuate cobalt chloride-induced cardiotoxicity and endothelial dysfunction through modulating miR-143-3P/MAPK/MCP-1, ERK5/CXCR4, Orai-1/STIM-1 signaling pathways" [Int. Immunopharmacol. 140 (2024) 112777]. | Int Immunopharmacol | 2026 | 42760158 | PubTator, text mining | PubMed |
| β-carotene alleviates PM2.5-induced pulmonary fibrosis via suppression of the Frizzled5-mediated Wnt5a/Ca2+pathway. | Ecotoxicol Environ Saf | 2026 | 42759460 | PubTator, text mining | PubMed |
| The many faces of Orai1 dysfunction: Molecular mechanisms and clinical manifestations. | J Gen Physiol | 2026 | 42671323 | PubTator, text mining | PubMed |
1 to 10 of 3,783
See all 3,783 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/84876
GET https://conductscience.org/api/genes/v1/84876/patents?page=2