Gene · 8493
PPM1D: protein phosphatase, Mg2+/Mn2+ dependent 1D
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PPM1D: protein phosphatase, Mg2+/Mn2+ dependent 1D. Genes, record 8493. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8493
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15297 | Protein phosphatase 1D | 605 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents32
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 3983 | O15297 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3983 | O15297 | Espacenet |
| US 12201620 B2 | 2025-01-21 | 1 | O15297 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7917 | O15297 | Espacenet |
| US 11898154 B2 | 2024-02-13 | 84 | O15297 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 1899 | O15297 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 68971 | O15297 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 171942 | O15297 | Espacenet |
| US 11304938 B2 | 2022-04-19 | 1 | O15297 | Espacenet |
| JP 2022513375 A | 2022-02-07 | 16 | O15297 | Espacenet |
1 to 10 of 32
See all 32 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,526
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PPM1D papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 43 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 23 | 2025 |
| P01CA066996 | Development of Novel Therapeutic Strategies in Human Leukemias | 14 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 12 | 2025 |
| ZIABC011197 | Regulation and Function of WIP1 Phosphatase and its Role in Tumor Cells | 12 | 2025 |
| R01HL148565 | Clonal Hematopoiesis in the Women's Health Initiative | 10 | 2025 |
| P01CA265748 | Modifiable Drivers of Expansion and Malignant Transformation from Clonal Hematopoiesis | 7 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 7 | 2025 |
| P50CA097257 | Brain Tumor SPORE Grant | 7 | 2025 |
| K12CA087723 | Dana Farber/Harvard Cancer Consortium Career Development Program in Clinical Oncology | 6 | 2025 |
1 to 10 of 1,526Source NIH's project files
See all 1,526 nih grantsPapers2,396
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| MCPH1 and DNA Damage Response Pathway Genes as Candidate Susceptibility Loci in Hereditary Breast Cancer. | Diagnostics (Basel) | 2026 | 42793752 | PubTator, text mining | PubMed |
| Clonal Hematopoiesis of Indeterminate Potential Proteomic Risk Score for Predicting Clinical Outcome in Patients With Heart Failure With Preserved Ejection Fraction. | Circ Heart Fail | 2026 | 42765309 | PubTator, text mining | PubMed |
| SelO functions as a tumor suppressor through AMPylating Cdk5rap3. | Proc Natl Acad Sci U S A | 2026 | 42735321 | PubTator, text mining | PubMed |
| Cancer treatment alters mutant selection in normal esophagus. | Nat Genet | 2026 | 42728384 | PubTator, text mining | PubMed |
| Diffuse intrinsic pontine glioma in the era of H3 K27-altered diffuse midline glioma. | Crit Rev Oncol Hematol | 2026 | 42692100 | PubTator, text mining | PubMed |
| TP53-mutant CHIP defines a pro-inflammatory phenotype and predicts adverse outcomes after CAR T-cell therapy. | Leukemia | 2026 | 42637877 | PubTator, text mining | PubMed |
| Liquid biopsies reveal dual compartments of cancer risk from tumor and host-derived mutations. | Bioinformatics | 2026 | 42635246 | PubTator, text mining | PubMed |
| Weekly Metronomic Venetoclax and Decitabine/Cedazuridine in Acute Myeloid Leukemia Patient Declining Blood Transfusion. | Case Rep Oncol | 2026 | 42626761 | PubTator, text mining | PubMed |
| Aryl hydrocarbon receptor modulates dysregulatory inflammatory responses in human retinal pigment epithelial cells. | Biochem Biophys Res Commun | 2026 | 42617404 | PubTator, text mining | PubMed |
| Late acquisition of BCR::ABL1 during clonal evolution of SAMD9-associated MDS with phenotypic shift from AML to B-ALL. | Int J Hematol | 2026 | 42533241 | PubTator, text mining | PubMed |
1 to 10 of 2,396
See all 2,396 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8493
GET https://conductscience.org/api/genes/v1/8493/patents?page=2