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Gene · 8493

PPM1D: protein phosphatase, Mg2+/Mn2+ dependent 1D

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPM1D: protein phosphatase, Mg2+/Mn2+ dependent 1D. Genes, record 8493. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8493

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Gene

Symbol
PPM1D
HGNC
Name
protein phosphatase, Mg2+/Mn2+ dependent 1D
HGNC
NCBI Gene ID
8493
NCBI Gene
HGNC ID
HGNC:9277
HGNC
Ensembl
ENSG00000170836
NCBI Gene
Aliases
IDDGIP, JDVS, PP2C-DELTA, WIP1, Wip1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15297Protein phosphatase 1D6051Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-293983O15297Espacenet
JP 2025517969 A2025-06-123983O15297Espacenet
US 12201620 B22025-01-211O15297Espacenet
JP 2024123008 A2024-09-107917O15297Espacenet
US 11898154 B22024-02-1384O15297Espacenet
US 11708396 B22023-07-251899O15297Espacenet
US 11446398 B22022-09-2068971O15297Espacenet
JP 2022524081 A2022-04-27171942O15297Espacenet
US 11304938 B22022-04-191O15297Espacenet
JP 2022513375 A2022-02-0716O15297Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,526

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPM1D papersNewest fiscal year
P30CA008748Cancer Center Support Grant432025
P30CA016672Cancer Center Support Grant232025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias142025
P30CA021765Cancer Center Support Grant (CCSG)122025
ZIABC011197Regulation and Function of WIP1 Phosphatase and its Role in Tumor Cells122025
R01HL148565Clonal Hematopoiesis in the Women's Health Initiative102025
P01CA265748Modifiable Drivers of Expansion and Malignant Transformation from Clonal Hematopoiesis72025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant72025
P50CA097257Brain Tumor SPORE Grant72025
K12CA087723Dana Farber/Harvard Cancer Consortium Career Development Program in Clinical Oncology62025

1 to 10 of 1,526Source NIH's project files

See all 1,526 nih grants

Papers2,396

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MCPH1 and DNA Damage Response Pathway Genes as Candidate Susceptibility Loci in Hereditary Breast Cancer.Diagnostics (Basel)202642793752PubTator, text miningPubMed
Clonal Hematopoiesis of Indeterminate Potential Proteomic Risk Score for Predicting Clinical Outcome in Patients With Heart Failure With Preserved Ejection Fraction.Circ Heart Fail202642765309PubTator, text miningPubMed
SelO functions as a tumor suppressor through AMPylating Cdk5rap3.Proc Natl Acad Sci U S A202642735321PubTator, text miningPubMed
Cancer treatment alters mutant selection in normal esophagus.Nat Genet202642728384PubTator, text miningPubMed
Diffuse intrinsic pontine glioma in the era of H3 K27-altered diffuse midline glioma.Crit Rev Oncol Hematol202642692100PubTator, text miningPubMed
TP53-mutant CHIP defines a pro-inflammatory phenotype and predicts adverse outcomes after CAR T-cell therapy.Leukemia202642637877PubTator, text miningPubMed
Liquid biopsies reveal dual compartments of cancer risk from tumor and host-derived mutations.Bioinformatics202642635246PubTator, text miningPubMed
Weekly Metronomic Venetoclax and Decitabine/Cedazuridine in Acute Myeloid Leukemia Patient Declining Blood Transfusion.Case Rep Oncol202642626761PubTator, text miningPubMed
Aryl hydrocarbon receptor modulates dysregulatory inflammatory responses in human retinal pigment epithelial cells.Biochem Biophys Res Commun202642617404PubTator, text miningPubMed
Late acquisition of BCR::ABL1 during clonal evolution of SAMD9-associated MDS with phenotypic shift from AML to B-ALL.Int J Hematol202642533241PubTator, text miningPubMed

1 to 10 of 2,396

See all 2,396 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8493

GET https://conductscience.org/api/genes/v1/8493/patents?page=2