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Gene · 8503

PIK3R3: phosphoinositide-3-kinase regulatory subunit 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PIK3R3: phosphoinositide-3-kinase regulatory subunit 3. Genes, record 8503. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8503

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Gene

Symbol
PIK3R3
HGNC
Name
phosphoinositide-3-kinase regulatory subunit 3
HGNC
NCBI Gene ID
8503
NCBI Gene
HGNC ID
HGNC:8981
HGNC
Ensembl
ENSG00000117461
NCBI Gene
Aliases
p55, p55-GAMMA, p55PIK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92569Phosphatidylinositol 3-kinase regulatory subunit gamma4610Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-291682Q92569Espacenet
JP 2025517969 A2025-06-121682Q92569Espacenet
JP 2024123008 A2024-09-107632Q92569Espacenet
JP 2024123008 A2024-09-107635Q92569Espacenet
JP 2024123008 A2024-09-107636Q92569Espacenet
JP 2023123507 A2023-09-058Q92569Espacenet
US 11446398 B22022-09-2063161Q92569Espacenet
US 11446398 B22022-09-2063162Q92569Espacenet
US 11446398 B22022-09-2063164Q92569Espacenet
JP 2022524081 A2022-04-27166132Q92569Espacenet

1 to 10 of 45

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Drugs28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APITOLISIBCHEMBL1922094PI3-kinase class I inhibitorINHIBITORChEMBL
AZD-6482CHEMBL2165191PI3-kinase class I inhibitorINHIBITORChEMBL
BGT-226CHEMBL3545096PI3-kinase class I inhibitorINHIBITORChEMBL
BGT-226 FREE BASECHEMBL3218578PI3-kinase class I inhibitorINHIBITORChEMBL
BUPARLISIBCHEMBL2017974PI3-kinase class I inhibitorINHIBITORChEMBL
DACTOLISIBCHEMBL1879463PI3-kinase class I inhibitorINHIBITORChEMBL
DS-7423CHEMBL3545248PI3-kinase class I inhibitorINHIBITORChEMBL
GEDATOLISIBCHEMBL592445PI3-kinase class I inhibitorINHIBITORChEMBL
GSK-1059615CHEMBL3544966PI3-kinase class I inhibitorINHIBITORChEMBL
IZORLISIBCHEMBL1684984PI3-kinase class I inhibitorINHIBITORChEMBL

1 to 10 of 28

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Trials203

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07447076PAXALISIBPHASE2ClinicalTrials.gov
NCT07391215PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT07287202PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT06757634GEDATOLISIBPHASE3ClinicalTrials.gov
NCT06208657PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT06190899GEDATOLISIBPHASE1/PHASE2ClinicalTrials.gov
NCT05501886GEDATOLISIBPHASE3ClinicalTrials.gov
NCT05183204PAXALISIBPHASE2ClinicalTrials.gov
NCT05009992PAXALISIBPHASE2ClinicalTrials.gov
NCT04906096PAXALISIBPHASE2ClinicalTrials.gov

1 to 10 of 203

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NIH grants1,139

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePIK3R3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant202025
P30CA016672Cancer Center Support Grant112025
P30CA006516Dana-Farber/Harvard Cancer Center32025
P30CA006973Regional Oncology Research Center32025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant32025
P30CA023108Cancer Center Support Grant32025
P30CA046934University of Colorado Cancer Center Support Grant32025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center32025
P30DK036836Diabetes Research Center32025
P50CA092629SPORE in Prostate Cancer32025

1 to 10 of 1,139Source NIH's project files

See all 1,139 nih grants

Papers1,831

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genome-wide CRISPRi screen in human iNeurons identifies novel negative mTOR regulator genes associated with focal cortical dysplasia.Neurobiol Dis202642731765PubTator, text miningPubMed
[Retracted] MicroRNA‑365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3.Oncol Rep202642535403PubTator, text miningPubMed
Systematic pan-cancer analysis identifies PIK3R3 as a lipid metabolism and immune regulation prognostic biomarker.Open Med (Wars)202642483220PubTator, text miningPubMed
PI3K gene variants are associated with elevated IL-6 levels and COVID-19 severe outcomes in a multicenter study.Sci Rep202642469329PubTator, text miningPubMed
Network pharmacology, molecular docking, and In Vitro evaluation of morin against gastric cancer.Mol Divers202641961389PubTator, text miningPubMed
Endogenous promoter G-quadruplexes scaffold apurinic/apyrimidinic endonuclease (APE1) to drive gene expression.Nucleic Acids Res202641925230PubTator, text miningPubMed
Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.Signal Transduct Target Ther202641912482PubTator, text miningPubMed
Exploring hub genes related to adipocytokines in keloids: a combined analysis integrating single-cell, Mendelian randomization and bulk transcriptome data with experimental verification.Front Mol Biosci202641889636PubTator, text miningPubMed
Nanoperlite Particles Enhance Fibrogenesis in Thyroid Orbital Fibroblasts: A Potential Activated Cell Source for Ocular Tissue Engineering.Biomed Res Int202641810219PubTator, text miningPubMed
TRIM28 Is an E3 Ligase of IRP2 Suppressing Ischemia/Reperfusion-Induced Myocardial Ferroptosis.Circulation202641797698PubTator, text miningPubMed

1 to 10 of 1,831

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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