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Gene · 8505

PARG: poly(ADP-ribose) glycohydrolase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PARG: poly(ADP-ribose) glycohydrolase. Genes, record 8505. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8505

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Gene

Symbol
PARG
HGNC
Name
poly(ADP-ribose) glycohydrolase
HGNC
NCBI Gene ID
8505
NCBI Gene
HGNC ID
HGNC:8605
HGNC
Ensembl
ENSG00000227345
NCBI Gene
Aliases
PARG99
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q86W56Poly(ADP-ribose) glycohydrolase97625Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1911808Q86W56Espacenet
EP 4641201 A22025-10-2912570Q86W56Espacenet
JP 2025517969 A2025-06-1212570Q86W56Espacenet
JP 2025517970 A2025-06-1211808Q86W56Espacenet
EP 4464338 A22024-11-20326Q86W56Espacenet
US 11680268 B22023-06-20326Q86W56Espacenet
US 11446398 B22022-09-2064487Q86W56Espacenet
US 11446398 B22022-09-2064490Q86W56Espacenet
JP 2022524081 A2022-04-27167458Q86W56Espacenet
JP 2022524081 A2022-04-27167461Q86W56Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants853

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePARG papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines222025
R01DK069710The Role of Nuclear PARPs in Signal-Regulated Transcription172025
ZIAHL000659ADP-ribosylation Cycles162025
P30CA047904Cancer Center Support Grant142025
P30CA016672Cancer Center Support Grant82025
T32CA009110Training in Areas Fundamental to Cancer Research82025
P20GM113117Chemical Biology of Infectious Disease72025
P30CA008748Cancer Center Support Grant72025
P30CA014051Cancer Center Support (Core) Grant72025
P30CA056036Translational Research in Cancer72025

1 to 10 of 853Source NIH's project files

See all 853 nih grants

Papers1,648

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Synthetic lethality and context-selective DNA-damage response dependencies: from genetic vulnerability to pharmacological translation.Drug Discov Today202642727625PubTator, text miningPubMed
Delaying Stress Granule Disassembly by PARG Inhibition Attenuates Renal Tubular Cell Pyroptosis in Acute Kidney Injury.Int J Mol Sci202642653197PubTator, text miningPubMed
EXPRESSION OF CONCERN: PARG Activity Mediates Intestinal Injury Induced by Splanchnic Artery Occlusion and Reperfusion.FASEB J202642647113PubTator, text miningPubMed
RSF1-Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites.Adv Sci (Weinh)202642635688PubTator, text miningPubMed
PARP1 hyperactivity stalls translation and triggers stress granule formation following DNA damage.J Cell Biol202642524886PubTator, text miningPubMed
The Rh blood group system: RHCE update.Immunohematology202642490338PubTator, text miningPubMed
PARP1 as a Central Node in DNA Repair and Epigenetic Regulation: Implications for Biomarker Discovery and Targeted Therapy in NSCLC.Mini Rev Med Chem202642474024PubTator, text miningPubMed
Neuroinflammation- molecular target based therapeutic approach.Adv Protein Chem Struct Biol202642448410PubTator, text miningPubMed
PARG inhibition reduces ssDNA levels and limits RPA loading upon replication fork collapse.EMBO Rep202642401703PubTator, text miningPubMed
Decoding PARP roles in breast cancer therapy resistance.Mol Biol Rep202642390770PubTator, text miningPubMed

1 to 10 of 1,648

See all 1,648 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8505

GET https://conductscience.org/api/genes/v1/8505/patents?page=2