Gene · 8505
PARG: poly(ADP-ribose) glycohydrolase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PARG: poly(ADP-ribose) glycohydrolase. Genes, record 8505. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8505
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q86W56 | Poly(ADP-ribose) glycohydrolase | 976 | 25 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 11808 | Q86W56 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 12570 | Q86W56 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 12570 | Q86W56 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 11808 | Q86W56 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 326 | Q86W56 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 326 | Q86W56 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 64487 | Q86W56 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 64490 | Q86W56 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 167458 | Q86W56 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 167461 | Q86W56 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants853
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PARG papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 22 | 2025 |
| R01DK069710 | The Role of Nuclear PARPs in Signal-Regulated Transcription | 17 | 2025 |
| ZIAHL000659 | ADP-ribosylation Cycles | 16 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 14 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| T32CA009110 | Training in Areas Fundamental to Cancer Research | 8 | 2025 |
| P20GM113117 | Chemical Biology of Infectious Disease | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 7 | 2025 |
| P30CA056036 | Translational Research in Cancer | 7 | 2025 |
1 to 10 of 853Source NIH's project files
See all 853 nih grantsPapers1,648
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Synthetic lethality and context-selective DNA-damage response dependencies: from genetic vulnerability to pharmacological translation. | Drug Discov Today | 2026 | 42727625 | PubTator, text mining | PubMed |
| Delaying Stress Granule Disassembly by PARG Inhibition Attenuates Renal Tubular Cell Pyroptosis in Acute Kidney Injury. | Int J Mol Sci | 2026 | 42653197 | PubTator, text mining | PubMed |
| EXPRESSION OF CONCERN: PARG Activity Mediates Intestinal Injury Induced by Splanchnic Artery Occlusion and Reperfusion. | FASEB J | 2026 | 42647113 | PubTator, text mining | PubMed |
| RSF1-Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites. | Adv Sci (Weinh) | 2026 | 42635688 | PubTator, text mining | PubMed |
| PARP1 hyperactivity stalls translation and triggers stress granule formation following DNA damage. | J Cell Biol | 2026 | 42524886 | PubTator, text mining | PubMed |
| The Rh blood group system: RHCE update. | Immunohematology | 2026 | 42490338 | PubTator, text mining | PubMed |
| PARP1 as a Central Node in DNA Repair and Epigenetic Regulation: Implications for Biomarker Discovery and Targeted Therapy in NSCLC. | Mini Rev Med Chem | 2026 | 42474024 | PubTator, text mining | PubMed |
| Neuroinflammation- molecular target based therapeutic approach. | Adv Protein Chem Struct Biol | 2026 | 42448410 | PubTator, text mining | PubMed |
| PARG inhibition reduces ssDNA levels and limits RPA loading upon replication fork collapse. | EMBO Rep | 2026 | 42401703 | PubTator, text mining | PubMed |
| Decoding PARP roles in breast cancer therapy resistance. | Mol Biol Rep | 2026 | 42390770 | PubTator, text mining | PubMed |
1 to 10 of 1,648
See all 1,648 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8505
GET https://conductscience.org/api/genes/v1/8505/patents?page=2