Gene · 8535
CBX4: chromobox 4
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. CBX4: chromobox 4. Genes, record 8535. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8535
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O00257 | E3 SUMO-protein ligase CBX4 | 560 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents11
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 2708 | O00257 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2708 | O00257 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5001 | O00257 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 15217 | O00257 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 118188 | O00257 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 1643 | O00257 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 5001 | O00257 | Espacenet |
| JP 2018023373 A | 2018-02-15 | 27728 | O00257 | Espacenet |
| US 9572897 B2 | 2017-02-21 | 5001 | O00257 | Espacenet |
| US 9303079 B2 | 2016-04-05 | 5001 | O00257 | Espacenet |
1 to 10 of 11
See all 11 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,409
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CBX4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA014236 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 4 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30CA023168 | Cancer Center Support Grant | 4 | 2025 |
| U01CA209414 | The Boston Lung Cancer Survival Cohort | 4 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 3 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,409Source NIH's project files
See all 1,409 nih grantsPapers1,770
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Metabolic phenotype dimensions and longitudinal renal function in type 2 diabetes: a principal component analysis-based approach with UACR integration. | Front Endocrinol (Lausanne) | 2026 | 42741563 | PubTator, text mining | PubMed |
| Chromobox 4 interacts with pregnane X receptor to repress CYP3A4 expression through polycomb repressive complex 1/2-mediated epigenetic regulation. | Drug Metab Dispos | 2026 | 42685388 | PubTator, text mining | PubMed |
| Multidimensional physiological impairments are associated with frailty and survival in older patients with cancer. | J Transl Int Med | 2026 | 42657366 | PubTator, text mining | PubMed |
| Correlation Between Hysteroscopic Findings and Histopathological Evidence of Chronic Endometritis in Reproductive Age Women With Gynecological Disorders. | J Minim Invasive Gynecol | 2026 | 42617996 | PubTator, text mining | PubMed |
| Changes in Toddler Diet Quality Between Ages 12 and 24 Months Using the Healthy Eating Index-Toddlers-2020: A Secondary Analysis of a Prospective Cohort. | J Acad Nutr Diet | 2026 | 42342117 | PubTator, text mining | PubMed |
| Mechanisms by which chromobox homolog 4 regulates angiogenic mimicry and angiogenic activity in osteosarcoma. | J Pharmacol Exp Ther | 2026 | 42139798 | PubTator, text mining | PubMed |
| Postoperative Adjuvant Transcatheter Arterial Chemoembolization (TACE) for Hepatocellular Carcinoma: Patient Selection and Clinical Predictors of Therapeutic Benefit. | J Hepatocell Carcinoma | 2026 | 42093753 | PubTator, text mining | PubMed |
| Quantifying direct genetic signal captured by principal component adjustment. | Proc Natl Acad Sci U S A | 2026 | 42060716 | PubTator, text mining | PubMed |
| Correction: CBX4 facilitates EV71 replication by SUMOylation and stabilizing 3D polymerase. | Front Microbiol | 2026 | 42052387 | PubTator, text mining | PubMed |
| Metabolic Adaptations to Caloric Restriction: Time- and Group-Dependent Metabolomic Signatures from the CALERIE™ Trial. | Res Sq | 2026 | 41960328 | PubTator, text mining | PubMed |
1 to 10 of 1,770
See all 1,770 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8535
GET https://conductscience.org/api/genes/v1/8535/patents