Gene · 85358
SHANK3: SH3 and multiple ankyrin repeat domains 3
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. SHANK3: SH3 and multiple ankyrin repeat domains 3. Genes, record 85358. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/85358
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9BYB0 | SH3 and multiple ankyrin repeat domains protein 3 | 1,806 | 3 | GeneID, HGNC |
Source UniProt
Patents1
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein |
|---|---|---|---|
| WO 2021160937 A1 | 2021-08-19 | 36 | Q9BYB0 |
Source Espacenet
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,712
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SHANK3 papers | Newest fiscal year |
|---|---|---|---|
| U54NS092090 | Developmental Synaptopathies Associated with TSC, PTEN, SHANK3 and SynGAP1 Pathogenic Variants | 21 | 2025 |
| ZICMH002961 | Neurodevelopmental and Behavioral Phenotyping | 17 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 9 | 2025 |
| R01MH101221 | Rare Mutations and Autism Spectrum Disorders | 7 | 2025 |
| T32MH065215 | Postdoctoral Program in Functional Neurogenomics | 7 | 2025 |
| R01MH071316 | Rac-GEF signaling in dendritic spines | 6 | 2025 |
| P50HD105351 | Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center | 5 | 2025 |
| R01HD036071 | Genotype-Phenotype Relationships in Fragile X Families | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P50HD103555 | Baylor College of Medicine Intellectual and Developmental Disabilities Research Center | 4 | 2025 |
1 to 10 of 1,712Source NIH's project files
See all 1,712 nih grantsPapers2,252
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| SHANK3 regulates nuclear hnRNP K and oxidative stress-associated DNA damage signaling in neurons. | Neurobiol Dis | 2026 | 42815651 | PubTator, text mining | PubMed |
| Prenatal and Postnatal Identification of Phelan-McDermid Syndrome in a Tertiary Referral Center: A 15-Case Series and Literature Review. | J Clin Med | 2026 | 42795903 | PubTator, text mining | PubMed |
| Gut Microbiota-Elicited Aberrant Phosphorylation Induces Protein Structural Anomalies: A Non-Negligible Pathogenic Driver of Autism Spectrum Disorder. | Microorganisms | 2026 | 42795509 | PubTator, text mining | PubMed |
| Neuroimmune Dysregulation and Synaptic Pruning in Autism Spectrum Disorder. | Biology (Basel) | 2026 | 42737971 | PubTator, text mining | PubMed |
| Diagnostic Yield of Whole Exome Sequencing in Autism Spectrum Disorder Patients at a Tertiary Center in Saudi Arabia. | J Autism Dev Disord | 2026 | 42606785 | PubTator, text mining | PubMed |
| Early-life exposure to polypropylene microplastics and DEHP induces ASD-relevant neurodevelopmental alterations involving mTOR-regulated autophagy impairment. | Ecotoxicol Environ Saf | 2026 | 42600301 | PubTator, text mining | PubMed |
| Beyond the Spectrum: A Case Report of Phelan-McDermid Syndrome and the Atypical Teratoid/Rhabdoid Tumor Co-Occurrence. | Mol Syndromol | 2026 | 42598376 | PubTator, text mining | PubMed |
| Age-Related Increases in 40Hz Neural Synchrony Are Specific to Typical Development: A Cross-Sectional Study of Autism Spectrum Disorder. | bioRxiv | 2026 | 42523404 | PubTator, text mining | PubMed |
| Non-coding RNA dysregulation in autism spectrum disorder: Mechanisms, biomarkers, and therapeutic perspectives. | Behav Brain Res | 2026 | 42480870 | PubTator, text mining | PubMed |
| Subcortical Dendritic Scaffolding in Autism Spectrum Disorder: A Testable ANK2-SCN2A-SHANK Framework. | Int J Mol Sci | 2026 | 42450246 | PubTator, text mining | PubMed |
1 to 10 of 2,252
See all 2,252 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/85358
GET https://conductscience.org/api/genes/v1/85358/grants?page=2