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Gene · 85363

TRIM5: tripartite motif containing 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRIM5: tripartite motif containing 5. Genes, record 85363. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/85363

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Gene

Symbol
TRIM5
HGNC
Name
tripartite motif containing 5
HGNC
NCBI Gene ID
85363
NCBI Gene
HGNC ID
HGNC:16276
HGNC
Ensembl
ENSG00000132256
NCBI Gene
Aliases
RNF88, TRIM5alpha
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9C035Tripartite motif-containing protein 54932Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468188Q9C035Espacenet
EP 4650780 A22025-11-1910255Q9C035Espacenet
EP 4640849 A22025-10-291548Q9C035Espacenet
EP 4641201 A22025-10-2910565Q9C035Espacenet
JP 2025519096 A2025-06-241548Q9C035Espacenet
JP 2025517969 A2025-06-1210565Q9C035Espacenet
JP 2025517970 A2025-06-1210255Q9C035Espacenet
JP 2025032204 A2025-03-1137670Q9C035Espacenet
JP 2024161501 A2024-11-1910Q9C035Espacenet
EP 4461818 A22024-11-1337670Q9C035Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,840

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRIM5 papersNewest fiscal year
P30AI060354Harvard University Center for AIDS Research302025
P30AI027763UCSF-Bay Area Center for AIDS Research152025
P51OD011132Emory National Primate Research Center152025
R01AI052014HIV-1 Preintegration Trafficking and Nuclear Localization152025
P30AI050409Center for AIDS Research at Emory University132025
P51OD011106Wisconsin National Primate Research Center Support112025
R01AI120860Development of HIV capsid-targeting antivirals that affect immune response by modulating capsid stability and have improved resistance profiles102025
P51OD011104Tulane National Primate Research Center92025
P30AI036219Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)82025
P30CA015704Cancer Center Support Grant82025

1 to 10 of 1,840Source NIH's project files

See all 1,840 nih grants

Papers2,349

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TRIM21 Neutralizes Hazara Virus Using a Dual Mechanism of Nucleoprotein Caging and Ubiquitination.Viruses202642797805PubTator, text miningPubMed
Host genetic determinants of HTLV-1 infection outcomes.Immunol Res202642645607PubTator, text miningPubMed
In situ structure of the poxvirus portal complex.Nature202642527601PubTator, text miningPubMed
Independent proviral and antiviral host factors recognize the same capsid protein in divergent human herpesviruses.PLoS Pathog202642418426PubTator, text miningPubMed
Restraint of Powassan virus replication by TRIM5α facilitates viral avoidance of antiviral immunity.Commun Biol202642410041PubTator, text miningPubMed
TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus.Kaohsiung J Med Sci202642334177PubTator, text miningPubMed
Dynamic regulation-based stabilizing mutations are highly effective for designing RSV pre-fusion F mRNA vaccines.Biochem Biophys Res Commun202642172905PubTator, text miningPubMed
TRIM5 integrates hypoglycemic stress and influenza infection.Nat Commun202642086607PubTator, text miningPubMed
Restraint of Powassan virus replication by TRIM5α facilitates viral avoidance of antiviral immunity.bioRxiv202642051304PubTator, text miningPubMed
Host restriction factors and p17-Driven inflammaging in HIV-1: From molecular pathogenesis to functional cure.AIMS Microbiol202641938780PubTator, text miningPubMed

1 to 10 of 2,349

See all 2,349 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/85363

GET https://conductscience.org/api/genes/v1/85363/patents?page=2