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Gene · 8542

APOL1: apolipoprotein L1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. APOL1: apolipoprotein L1. Genes, record 8542. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8542

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Gene

Symbol
APOL1
HGNC
Name
apolipoprotein L1
HGNC
NCBI Gene ID
8542
NCBI Gene
HGNC ID
HGNC:618
HGNC
Ensembl
ENSG00000100342
NCBI Gene
Aliases
APO-L, APOL, APOL-I, FSGS4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14791Apolipoprotein L13985Ensembl, GeneID, HGNC

Source UniProt

Patents105

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026213607 A12026-10-0850O14791Espacenet
WO 2026171772 A12026-08-20107O14791Espacenet
JP 2026031975 A2026-02-251O14791Espacenet
JP 2026004568 A2026-01-1437685O14791Espacenet
JP 2026004568 A2026-01-1437686O14791Espacenet
JP 2026004568 A2026-01-1437687O14791Espacenet
JP 2026004568 A2026-01-1437688O14791Espacenet
EP 4650780 A22025-11-1911475O14791Espacenet
EP 4640849 A22025-10-291803O14791Espacenet
EP 4641201 A22025-10-2912023O14791Espacenet

1 to 10 of 105

See all 105 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,721

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAPOL1 papersNewest fiscal year
ZIAHG200362Genetic epidemiology of complex diseases172025
R01DK108803Multi-Omics and Chronic Kidney Disease: Correlation with Histology152025
UL1TR001881UCLA Clinical and Translational Science Institute152025
P30DK017047Diabetes Research Center142025
R01DK076077Adaptive and maladaptive repair after kidney injury142025
P30DK063491Diabetes Research Center (DRC)112025
R01DK108805APOL1 - associated nephropathy from human-derived, intrarenal perspective112025
U01DK11604114/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Scientific Data Research Center112025
U24HL135600Sickle Africa Data Coordinating Center112025
R01DK049419Role of bFGF low affinity receptors in childhood HIVAN102025

1 to 10 of 2,721Source NIH's project files

See all 2,721 nih grants

Papers3,519

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
HIV-associated nephropathy: A decade of clinical outcomes, global disparities and emerging promise.HIV Med202642808260PubTator, text miningPubMed
Autophagy and Mitophagy in Hypertensive Chronic Kidney Disease: Evidence Grading, Cell-Type Divergence, and a Working Lysosomal Hypothesis.Life (Basel)202642795346PubTator, text miningPubMed
APOL1, HIV, and Pregnancy Complications: Converging Risks for Kidney Disease.Kidney360202642782823PubTator, text miningPubMed
The APOL1 protective M1 modifier occurs exclusively with the KIK protein haplotype to suppress channel conductance.medRxiv202642779842PubTator, text miningPubMed
Blood pressure and APOL1 risk variants in a South African chronic haemodialysis population of African ancestry.Clin Kidney J202642761223PubTator, text miningPubMed
Coding, modifier, and regulatory effects shape circulating APOL1 levels.Hum Mol Genet202642758720PubTator, text miningPubMed
Differential regulation of basal and interferon-induced APOL1 gene expression in podocytes.Am J Physiol Renal Physiol202642734476PubTator, text miningPubMed
Sports Nephrology: Managing Hypertension, Acute Kidney Injury, and Cardiovascular Risk in a Collegiate Football Player.JACC Case Rep202642726044PubTator, text miningPubMed
APOL1 kidney disease: a critical narrative review of molecular mechanisms, clinical heterogeneity, and the emerging therapeutic landscape.Int Urol Nephrol202642709370PubTator, text miningPubMed
Beyond Genotype: Proteomic Risk Stratification for APOL1-Mediated Kidney Disease.Am J Kidney Dis202642705445PubTator, text miningPubMed

1 to 10 of 3,519

See all 3,519 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8542

GET https://conductscience.org/api/genes/v1/8542/patents?page=2