Gene · 8542
APOL1: apolipoprotein L1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. APOL1: apolipoprotein L1. Genes, record 8542. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8542
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14791 | Apolipoprotein L1 | 398 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents105
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026213607 A1 | 2026-10-08 | 50 | O14791 | Espacenet |
| WO 2026171772 A1 | 2026-08-20 | 107 | O14791 | Espacenet |
| JP 2026031975 A | 2026-02-25 | 1 | O14791 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 37685 | O14791 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 37686 | O14791 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 37687 | O14791 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 37688 | O14791 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 11475 | O14791 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1803 | O14791 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 12023 | O14791 | Espacenet |
1 to 10 of 105
See all 105 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,721
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | APOL1 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHG200362 | Genetic epidemiology of complex diseases | 17 | 2025 |
| R01DK108803 | Multi-Omics and Chronic Kidney Disease: Correlation with Histology | 15 | 2025 |
| UL1TR001881 | UCLA Clinical and Translational Science Institute | 15 | 2025 |
| P30DK017047 | Diabetes Research Center | 14 | 2025 |
| R01DK076077 | Adaptive and maladaptive repair after kidney injury | 14 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 11 | 2025 |
| R01DK108805 | APOL1 - associated nephropathy from human-derived, intrarenal perspective | 11 | 2025 |
| U01DK116041 | 14/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Scientific Data Research Center | 11 | 2025 |
| U24HL135600 | Sickle Africa Data Coordinating Center | 11 | 2025 |
| R01DK049419 | Role of bFGF low affinity receptors in childhood HIVAN | 10 | 2025 |
1 to 10 of 2,721Source NIH's project files
See all 2,721 nih grantsPapers3,519
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| HIV-associated nephropathy: A decade of clinical outcomes, global disparities and emerging promise. | HIV Med | 2026 | 42808260 | PubTator, text mining | PubMed |
| Autophagy and Mitophagy in Hypertensive Chronic Kidney Disease: Evidence Grading, Cell-Type Divergence, and a Working Lysosomal Hypothesis. | Life (Basel) | 2026 | 42795346 | PubTator, text mining | PubMed |
| APOL1, HIV, and Pregnancy Complications: Converging Risks for Kidney Disease. | Kidney360 | 2026 | 42782823 | PubTator, text mining | PubMed |
| The APOL1 protective M1 modifier occurs exclusively with the KIK protein haplotype to suppress channel conductance. | medRxiv | 2026 | 42779842 | PubTator, text mining | PubMed |
| Blood pressure and APOL1 risk variants in a South African chronic haemodialysis population of African ancestry. | Clin Kidney J | 2026 | 42761223 | PubTator, text mining | PubMed |
| Coding, modifier, and regulatory effects shape circulating APOL1 levels. | Hum Mol Genet | 2026 | 42758720 | PubTator, text mining | PubMed |
| Differential regulation of basal and interferon-induced APOL1 gene expression in podocytes. | Am J Physiol Renal Physiol | 2026 | 42734476 | PubTator, text mining | PubMed |
| Sports Nephrology: Managing Hypertension, Acute Kidney Injury, and Cardiovascular Risk in a Collegiate Football Player. | JACC Case Rep | 2026 | 42726044 | PubTator, text mining | PubMed |
| APOL1 kidney disease: a critical narrative review of molecular mechanisms, clinical heterogeneity, and the emerging therapeutic landscape. | Int Urol Nephrol | 2026 | 42709370 | PubTator, text mining | PubMed |
| Beyond Genotype: Proteomic Risk Stratification for APOL1-Mediated Kidney Disease. | Am J Kidney Dis | 2026 | 42705445 | PubTator, text mining | PubMed |
1 to 10 of 3,519
See all 3,519 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8542
GET https://conductscience.org/api/genes/v1/8542/patents?page=2