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LGR5: leucine rich repeat containing G protein-coupled receptor 5

1 protein, 172 patents, 0 drugs, 0 trials, 7,979 NIH grants and 10,968 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLGR5HGNC
Nameleucine rich repeat containing G protein-coupled receptor 5HGNC
NCBI Gene ID8549NCBI Gene
HGNC IDHGNC:4504HGNC
EnsemblENSG00000139292NCBI Gene
AliasesFEX, GPR49, GPR67, GRP49, HG38NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O75473Leucine-rich repeat-containing G protein-coupled receptor 59077Ensembl, GeneID, HGNCUniProt

Patents 172

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026125612 A2026-08-031O75473Espacenet
WO 2026121966 A22026-06-111O75473Espacenet
JP 2026083251 A2026-05-191O75473Espacenet
JP 2026077781 A2026-05-131O75473Espacenet
JP 2026004568 A2026-01-1451376O75473Espacenet
JP 2026500788 A2026-01-081O75473Espacenet
JP 2025542384 A2025-12-251O75473Espacenet
WO 2025244529 A12025-11-271O75473Espacenet
EP 4650780 A22025-11-192582O75473Espacenet
EP 4642443 A12025-11-051O75473Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 7979

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant882,025NIH's project files
P30CA016672Cancer Center Support Grant282,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology272,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital262,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases242,025NIH's project files
P30DK050306Center for Molecular Studies in Digestive and Liver Diseases232,025NIH's project files
P30DK056338Texas Medical Center Digestive Diseases Center232,025NIH's project files
P30DK034987Center for Gastrointestinal Biology and Disease222,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease202,025NIH's project files
P30CA014051Cancer Center Support (Core) Grant192,025NIH's project files

Papers 10968

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42806331PubTator, text miningPubMed
42770147PubTator, text miningPubMed
42765054PubTator, text miningPubMed
42763852PubTator, text miningPubMed
42763847PubTator, text miningPubMed
42761588PubTator, text miningPubMed
42738506PubTator, text miningPubMed
42738460PubTator, text miningPubMed
42737845PubTator, text miningPubMed
42736388PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license