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Gene · 8554

PIAS1: protein inhibitor of activated STAT 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PIAS1: protein inhibitor of activated STAT 1. Genes, record 8554. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8554

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Gene

Symbol
PIAS1
HGNC
Name
protein inhibitor of activated STAT 1
HGNC
NCBI Gene ID
8554
NCBI Gene
HGNC ID
HGNC:2752
HGNC
Ensembl
ENSG00000033800
NCBI Gene
Aliases
DDXBP1, GBP, GU/RH-II, ZMIZ3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75925E3 SUMO-protein ligase PIAS16511Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459680O75925Espacenet
EP 4650780 A22025-11-191280O75925Espacenet
EP 4641201 A22025-10-29915O75925Espacenet
WO 2025146688 A12025-07-101O75925Espacenet
JP 2025517969 A2025-06-12915O75925Espacenet
JP 2025517970 A2025-06-121280O75925Espacenet
US 11884978 B22024-01-30661O75925Espacenet
US 11446398 B22022-09-2068100O75925Espacenet
JP 2022524081 A2022-04-27171071O75925Espacenet
US 11078247 B22021-08-038446O75925Espacenet

1 to 10 of 20

See all 20 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,276

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePIAS1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant82025
P30CA033572Cancer Center Support Grant52025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center52025
P30CA016059Massey Cancer Center - Cancer Center Support Grant42025
P30CA076292Moffitt Cancer Center Support Grant42025
P30CA086862Cancer Center Support Grant42025
P30CA015704Cancer Center Support Grant32025
P30CA016042Cancer Center Support Grant32025
R01CA198279Shaping DNA Damage Response Networks Via Histone H2A Variants32025

1 to 10 of 1,276Source NIH's project files

See all 1,276 nih grants

Papers1,587

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Charting host structural variations in cervical cancer by long-read sequencing pinpoints a functional deletion in PIAS1.Genomics202642669360PubTator, text miningPubMed
Transcriptomic profiling reveals selective attenuation of interferon-associated inflammatory signaling and induction of metallothioneins by a zinc-containing oral rinse.Front Immunol202642577366PubTator, text miningPubMed
Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harb Perspect Biol202642575696PubTator, text miningPubMed
An Acetylation-Primed SUMOylation Switch Controls RORβ Stability through a p300-SIRT1 Regulatory Axis.Res Sq202642539049PubTator, text miningPubMed
Acetylation-Primed SUMOylation Drives RORβ Turnover via a p300-SIRT1 Regulatory Axis.bioRxiv202642427505PubTator, text miningPubMed
Reprogramming gut microenvironment for the treatment of acute severe ulcerative colitis via a synergistic therapy of necroptosis blockade and organoid transplantation.Nat Commun202642129174PubTator, text miningPubMed
PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly.Sci Adv202642054439PubTator, text miningPubMed
Identification of small ubiquitin-related modifier (SUMO)-related genes-based biomarkers in Alzheimer's disease based on bioinformatics analysis.Sci Rep202642009747PubTator, text miningPubMed
Targeted immune response gene expression profiles linked with necrosis and mortality in preterm infants with surgical necrotizing enterocolitis.World J Pediatr Surg202641919181PubTator, text miningPubMed
Genetic Influences on Disease-Modifying Therapy Response in Multiple Sclerosis: Current Insights and Future Directions.Balkan Med J202641918263PubTator, text miningPubMed

1 to 10 of 1,587

See all 1,587 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8554

GET https://conductscience.org/api/genes/v1/8554/patents