Gene · 8573
CASK: calcium/calmodulin dependent serine protein kinase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CASK: calcium/calmodulin dependent serine protein kinase. Genes, record 8573. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8573
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14936 | Peripheral plasma membrane protein CASK | 926 | 22 | Ensembl, GeneID, HGNC |
Source UniProt
Patents13
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 39733 | O14936 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 733 | O14936 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 733 | O14936 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10961 | O14936 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 10961 | O14936 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 113932 | O14936 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 589 | O14936 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 220168 | O14936 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 220168 | O14936 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 220168 | O14936 | Espacenet |
1 to 10 of 13
See all 13 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,095
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CASK papers | Newest fiscal year |
|---|---|---|---|
| P40OD010440 | Caenorhabditis Genetics Center | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 3 | 2025 |
| P30DK034989 | Yale Liver Center | 3 | 2025 |
| P40OD018537 | Bloomington Drosophila Stock Center at Indiana University | 3 | 2025 |
| R01MH101221 | Rare Mutations and Autism Spectrum Disorders | 3 | 2025 |
| R01NS117698 | Understanding the Etiology of CASK Associated Epileptic Encephalopathy | 3 | 2025 |
| K12HD000850 | Pediatric Scientist Development Program | 2 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 2 | 2025 |
| P50HD103538 | Intellectual and Developmental Disabilities Research Centers | 2 | 2025 |
1 to 10 of 1,095Source NIH's project files
See all 1,095 nih grantsPapers1,323
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| CNTNAP2 in neurodevelopmental disorders: Genetics, excitation/inhibition mechanisms and preclinical evidence. | Mol Cell Neurosci | 2026 | 42815598 | PubTator, text mining | PubMed |
| Clinical heterogeneity and diagnostic challenges in CASK-related neurodevelopmental disorders: a longitudinal observational study. | Front Psychiatry | 2026 | 42517139 | PubTator, text mining | PubMed |
| Synaptic Ca2+ channels and neurexins are linked through direct and indirect binding complexes. | Sci Rep | 2026 | 42457853 | PubTator, text mining | PubMed |
| Structural variant discovery and diagnostic impact in rare diseases from short-read and long-read sequencing. | medRxiv | 2026 | 42396270 | PubTator, text mining | PubMed |
| Intellectual Disability and Microcephaly With Pontine and Cerebellar Hypoplasia in Adults: Severity Spectrum and Diversity of the CASK Gene Aberrations. | Cureus | 2026 | 42367460 | PubTator, text mining | PubMed |
| Corrigendum to "Structural basis for the Ca2+/CaM-mediated regulation of CASK-CaMK" [Int. J. Biol. Macromol., 332 (2025) 148495]. | Int J Biol Macromol | 2026 | 42209362 | PubTator, text mining | PubMed |
| Clinical and genetic spectrum of CASK-related disorders in Chinese patients. | J Neurol | 2026 | 42133085 | PubTator, text mining | PubMed |
| CASK promotes non-small cell lung cancer growth through coordinated regulation of EGFR expression, trafficking, and p21 expression. | J Biomed Sci | 2026 | 42106797 | PubTator, text mining | PubMed |
| Helicobacter pylori-induced PPFIA4 orchestrates immune network-promoting gastritis and gastric bacterial colonization. | J Clin Invest | 2026 | 42065246 | PubTator, text mining | PubMed |
| Identification and validation of the potential therapeutic value of CASK in osteosarcoma: a computational analysis and in vitro experiments. | Front Oncol | 2026 | 41919243 | PubTator, text mining | PubMed |
1 to 10 of 1,323
See all 1,323 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8573
GET https://conductscience.org/api/genes/v1/8573/patents