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RUNX2: RUNX family transcription factor 2

1 protein, 73 patents, 0 drugs, 0 trials, 6,367 NIH grants and 22,018 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolRUNX2HGNC
NameRUNX family transcription factor 2HGNC
NCBI Gene ID860NCBI Gene
HGNC IDHGNC:10472HGNC
EnsemblENSG00000124813NCBI Gene
AliasesAML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2A1, PEBP2aA, PEBP2aA1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13950Runt-related transcription factor 25214Ensembl, GeneID, HGNCUniProt

Patents 73

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-299198Q13950Espacenet
JP 2025147176 A2025-10-0615590Q13950Espacenet
JP 2025517969 A2025-06-129198Q13950Espacenet
WO 2025096975 A12025-05-0815Q13950Espacenet
JP 2025028160 A2025-02-2815590Q13950Espacenet
EP 4504905 A22025-02-123Q13950Espacenet
KR 1020250010750 A2025-01-2115590Q13950Espacenet
KR 1020240170824 A2024-12-043Q13950Espacenet
JP 2024123008 A2024-09-108277Q13950Espacenet
JP 2024123008 A2024-09-108278Q13950Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 6367

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant572,025NIH's project files
P30CA008748Cancer Center Support Grant242,025NIH's project files
U54GM115516Northern New England Clinical and Translational Research Network202,025NIH's project files
ZIADE000380The role of stem cells in skeletal health and disease162,025NIH's project files
P30CA016058Cancer Center Support Grant142,025NIH's project files
T32AR056950Musculoskeletal Research Training Program142,025NIH's project files
P01AG036675Kynurenine accumulation drives loss of muscle and bone function with aging132,025NIH's project files
P30AR069620Michigan Integrative Musculoskeletal Health Core Center (Overall Application)132,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)132,025NIH's project files
R01DK047420Nuclear Events in PTHR1 Action on Bone132,025NIH's project files

Papers 22018

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826604PubTator, text miningPubMed
42823400PubTator, text miningPubMed
42821166PubTator, text miningPubMed
42820258PubTator, text miningPubMed
42802970PubTator, text miningPubMed
42802956PubTator, text miningPubMed
42802149PubTator, text miningPubMed
42792769PubTator, text miningPubMed
42791262PubTator, text miningPubMed
42788342PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license