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TNFSF11: TNF superfamily member 11

1 protein, 313 patents, 1 drug, 166 trials, 6,049 NIH grants and 24,404 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTNFSF11HGNC
NameTNF superfamily member 11HGNC
NCBI Gene ID8600NCBI Gene
HGNC IDHGNC:11926HGNC
EnsemblENSG00000120659NCBI Gene
AliasesCD254, ODF, OPGL, OPTB2, RANKL, TNLG6B, TRANCE, hRANKL2, sOdfNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O14788Tumor necrosis factor ligand superfamily member 113172Ensembl, GeneID, HGNCUniProt

Patents 313

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086743 A2026-05-26190O14788Espacenet
EP 4705273 A22026-03-11328O14788Espacenet
JP 2026004568 A2026-01-1468630O14788Espacenet
US 12473371 B22025-11-185O14788Espacenet
EP 4641202 A22025-10-29665O14788Espacenet
JP 2025147176 A2025-10-0613609O14788Espacenet
JP 2025147176 A2025-10-0616792O14788Espacenet
JP 2025532122 A2025-09-291O14788Espacenet
WO 2025186446 A12025-09-1240O14788Espacenet
EP 4613860 A12025-09-1040O14788Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DENOSUMABCHEMBL1237023Tumor necrosis factor ligand superfamily member 11 inhibitorINHIBITORChEMBL

Trials 166

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07537972DENOSUMABPHASE2ClinicalTrials.gov
NCT07283887DENOSUMABPHASE4ClinicalTrials.gov
NCT07281586DENOSUMABPHASE4ClinicalTrials.gov
NCT07085520DENOSUMABPHASE1ClinicalTrials.gov
NCT07062978DENOSUMABPHASE3ClinicalTrials.gov
NCT07056478DENOSUMABPHASE3ClinicalTrials.gov
NCT07034391DENOSUMABPHASE2ClinicalTrials.gov
NCT06938152DENOSUMABPHASE4ClinicalTrials.gov
NCT06811363DENOSUMABClinicalTrials.gov
NCT06804590DENOSUMABPHASE3ClinicalTrials.gov

NIH grants 6049

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant652,025NIH's project files
P30CA008748Cancer Center Support Grant402,025NIH's project files
P20GM125503Center for Musculoskeletal Disease Research (CMDR)272,025NIH's project files
R01AR043510Studies of the fate of the osteoclast242,025NIH's project files
P01CA100730Retrovirus Models of Cancer212,025NIH's project files
R01AR041398Novel Molecular Biomarkers of Bone Microarchitecture192,025NIH's project files
R01AR046713Cytokine regulation of RA synoviocyte phenotype192,025NIH's project files
R01AR062173The IL-23/IL-17 Axis in Inflammatory Arthritis192,025NIH's project files
R01AI044938Inhibition of STAT3 and inflammatory cytokine production182,025NIH's project files
R01AR050401Cytokine Balance in Rheumatoid Arthritis182,025NIH's project files

Papers 24404

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825930PubTator, text miningPubMed
42824795PubTator, text miningPubMed
42824268PubTator, text miningPubMed
42823111PubTator, text miningPubMed
42818898PubTator, text miningPubMed
42818447PubTator, text miningPubMed
42816999PubTator, text miningPubMed
42808736PubTator, text miningPubMed
42805952PubTator, text miningPubMed
42804367PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license