ConductScience.org, home

Gene · 8607

RUVBL1: RuvB like AAA ATPase 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. RUVBL1: RuvB like AAA ATPase 1. Genes, record 8607. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8607

On this page

Gene

Symbol
RUVBL1
HGNC
Name
RuvB like AAA ATPase 1
HGNC
NCBI Gene ID
8607
NCBI Gene
HGNC ID
HGNC:10474
HGNC
Ensembl
ENSG00000175792
NCBI Gene
Aliases
ECP-54, ECP54, INO80H, NMP 238, NMP238, PONTIN, Pontin52, RVB1, Rvb1, TIH1, TIP49, TIP49A, TIP49a
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y265RuvB-like 145636Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462504Q9Y265Espacenet
EP 4650780 A22025-11-195177Q9Y265Espacenet
JP 2025517970 A2025-06-125177Q9Y265Espacenet
WO 2024240908 A12024-11-2829Q9Y265Espacenet
JP 2023550657 A2023-12-041Q9Y265Espacenet
JP 2023513118 A2023-03-306Q9Y265Espacenet
KR 1020220139869 A2022-10-173Q9Y265Espacenet
US 11446398 B22022-09-2076200Q9Y265Espacenet
JP 2022524081 A2022-04-27179171Q9Y265Espacenet
WO 2021160464 A12021-08-193Q9Y265Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,304

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRUVBL1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30CA036727Buffett Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant42025
P40OD010440Caenorhabditis Genetics Center42025
R01GM094231COMPUTATIONAL TOOLS FOR MASS SPECTROMETRY-BASED INTERACTOME DATA42025
ZIASC010074HSP90 and HSP70 Chaperone Proteins and Interactors in Cellular Signal Transduction42025
P01CA013106Targeting Transcription and Splicing in Cancer32025
P01CA092584Structural Cell Biology of DNA Repair Machines32025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025
P30CA016086Cancer Center Support Grant32025

1 to 10 of 1,304Source NIH's project files

See all 1,304 nih grants

Papers1,564

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genome-scale perturbation signatures from primary human CD4+ T cells improve genetics-based prioritization of immune drug targets.bioRxiv202642779863PubTator, text miningPubMed
Interrogation of functional variants in COPD GWAS loci by massively parallel reporter assays.Am J Respir Cell Mol Biol202642745457PubTator, text miningPubMed
Cellular subpopulation remodeling and biphasic molecular dynamics in glioma recurrence: a multi-omics analysis and diagnostic markers screening using liquid biopsy samples.Transl Oncol202642691509PubTator, text miningPubMed
Disruption of RBPJ in liver cancer-infiltrating T cells enhances antitumor immunity through remodeling epigenetic landscape.Cell Death Differ202642562885PubTator, text miningPubMed
RUVBL1 supports TIP60-associated proteasome adaptation and temozolomide resistance in glioblastoma.Cell Signal202642551615PubTator, text miningPubMed
Effects of Kiperin Elixea, a multicomponent antioxidant supplement, on redox homeostasis and longevity-associated gene expression in human epithelial cell models.Front Aging202642375387PubTator, text miningPubMed
(+)-Miliusol suppresses the Warburg effect and induces regulated cell death in triple-negative breast cancer through targeting EIF3D and remodeling cancer metabolism.Acta Pharm Sin B202642368564PubTator, text miningPubMed
Identification and validation of prognostic genes related to centrosome amplification in multiple myeloma.PeerJ202642261309PubTator, text miningPubMed
Insights into the function and structure of the R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) chaperone complex.Cell Stress Chaperones202642248294PubTator, text miningPubMed
PIWIL1 activates the R2TP-TELO2-mTORC1 axis independently of piRNA to promote TOP mRNA translation in gastric cancer.Oncogene202642020726PubTator, text miningPubMed

1 to 10 of 1,564

See all 1,564 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8607

GET https://conductscience.org/api/genes/v1/8607/patents?page=2