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Gene · 8630

HSD17B6: hydroxysteroid 17-beta dehydrogenase 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HSD17B6: hydroxysteroid 17-beta dehydrogenase 6. Genes, record 8630. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8630

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Gene

Symbol
HSD17B6
HGNC
Name
hydroxysteroid 17-beta dehydrogenase 6
HGNC
NCBI Gene ID
8630
NCBI Gene
HGNC ID
HGNC:23316
HGNC
Ensembl
ENSG00000025423
NCBI Gene
Aliases
HSE, RODH, SDR9C6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O1475617-beta-hydroxysteroid dehydrogenase type 63170Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195203O14756Espacenet
JP 2025517970 A2025-06-125203O14756Espacenet
US 11446398 B22022-09-2039328O14756Espacenet
US 11446398 B22022-09-2039329O14756Espacenet
US 11446398 B22022-09-2039330O14756Espacenet
US 11446398 B22022-09-2039332O14756Espacenet
US 11446398 B22022-09-2039334O14756Espacenet
JP 2022524081 A2022-04-27142299O14756Espacenet
JP 2022524081 A2022-04-27142300O14756Espacenet
JP 2022524081 A2022-04-27142301O14756Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,025

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHSD17B6 papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology192025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer102025
P50CA097186The Pacific Northwest Prostate Cancer SPORE102025
P30CA016672Cancer Center Support Grant82025
P30CA008748Cancer Center Support Grant62025
P30CA016056Roswell Park Cancer Center Support Grant52025
R01EY009339Retinoids in Vision52025
P30CA013148Comprehensive Cancer Center Support Grant42025
U01DK061734Clinical Research on Nonalcoholic Fatty Liver Disease42025
P30CA015704Cancer Center Support Grant32025

1 to 10 of 1,025Source NIH's project files

See all 1,025 nih grants

Papers1,491

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Effects of Fermentation Broth from the Biocontrol Fungus Diaporthe novem on Colletotrichum jiangxiense, the Causal Agent of Rhododendron Brown Spot, and Transcriptomic Analysis of the Pathogen.Microorganisms202642514034PubTator, text miningPubMed
Discovery of a borylated aza-arene chemotype as a direct HSF1 inhibitor targeting the DNA-binding domain.Eur J Med Chem202642275931PubTator, text miningPubMed
An integrated computational framework for hazard identification of emerging contaminants: a case study of 6PPD.Environ Int202642225002PubTator, text miningPubMed
Biomimetic Compartmentalization of Enzymes for Sustainable Coenzyme Recycling in Oxidative Photocatalysis.Chembiochem202642178976PubTator, text miningPubMed
Vitamin A as an essential nutrient: advances in biosynthesis.Curr Opin Biotechnol202642161096PubTator, text miningPubMed
An integrated bioinformatics analysis identifying ALOX15 as a novel pharmacological target for retinitis pigmentosa and diabetic retinopathy.Medicine (Baltimore)202642152388PubTator, text miningPubMed
The proteomics analysis of mitochondria-enriched fractions reveals alteration of key mitochondrial pathways in breast cancer cell lines.J Proteomics202642025918PubTator, text miningPubMed
Genetic evidence for causal relationship between general cognition and treatment resistance in schizophrenia.Transl Psychiatry202641922311PubTator, text miningPubMed
CSF1 regulates inflammation and apoptosis in intervertebral disc degeneration.Sci Rep202641912624PubTator, text miningPubMed
Unraveling the toxicological impact of Bisphenol A exposure on dermatomyositis: An integration of network toxicology and machine learning approaches.PLoS One202641911226PubTator, text miningPubMed

1 to 10 of 1,491

See all 1,491 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8630

GET https://conductscience.org/api/genes/v1/8630/patents?page=2