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Gene · 8644

AKR1C3: aldo-keto reductase family 1 member C3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AKR1C3: aldo-keto reductase family 1 member C3. Genes, record 8644. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8644

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Gene

Symbol
AKR1C3
HGNC
Name
aldo-keto reductase family 1 member C3
HGNC
NCBI Gene ID
8644
NCBI Gene
HGNC ID
HGNC:386
HGNC
Ensembl
ENSG00000196139
NCBI Gene
Aliases
DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, KIAA0119, PGFS, hluPGFS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P42330Aldo-keto reductase family 1 member C332367Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437069P42330Espacenet
EP 4650780 A22025-11-1910332P42330Espacenet
JP 2025517970 A2025-06-1210332P42330Espacenet
JP 2025081326 A2025-05-2737P42330Espacenet
JP 2025062604 A2025-04-143973P42330Espacenet
JP 2025032204 A2025-03-1124365P42330Espacenet
JP 2025024198 A2025-02-199010P42330Espacenet
EP 4461818 A22024-11-1324365P42330Espacenet
JP 2023058610 A2023-04-2524365P42330Espacenet
US 11446398 B22022-09-203973P42330Espacenet

1 to 10 of 34

See all 34 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,514

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAKR1C3 papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology862025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer282025
P50CA097186The Pacific Northwest Prostate Cancer SPORE232025
R01CA172382Elucidating a novel molecular biomarker for castration-resistant prostate cancer112025
T32ES019851Translational Research Training Program in Environmental Health Sciences102025
P30CA016056Roswell Park Cancer Center Support Grant92025
P30CA006973Regional Oncology Research Center82025
P30CA016672Cancer Center Support Grant82025
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b582025
UL1TR001881UCLA Clinical and Translational Science Institute82025

1 to 10 of 1,514Source NIH's project files

See all 1,514 nih grants

Papers2,828

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Network toxicology and machine learning analysis of MC-LR-associated hepatocellular carcinoma.J Environ Sci Health B202642811799PubTator, text miningPubMed
Metabolomics and network pharmacology identify three key bioactive organic acid metabolites in Amomum tsao-ko.Genomics202642764030PubTator, text miningPubMed
Integrating target prediction and transcriptomic analysis identifies the AKR1C2-KRT8 axis in rotenone-induced dopaminergic neuron injury.Brain Res Bull202642679909PubTator, text miningPubMed
Integrated computational analysis prioritizes candidate targets and pathways linking ochratoxin A exposure to hepatocellular carcinoma.PLoS One202642672059PubTator, text miningPubMed
Triphala Targets the SLC7A11-GSH-GPX4 Axis to Trigger Ferroptosis in Oral Cancer: An Integrated Network Pharmacology, Molecular Docking, and Experimental Validation Study.Chem Biol Drug Des202642644728PubTator, text miningPubMed
Identification of candidate macrophage-ferroptosis crosstalk genes associated with immune infiltration in myocardial infarction: A bioinformatics analysis.PLoS One202642640988PubTator, text miningPubMed
Cotinine enhances androgen receptor stability and promotes androgen-dependent proliferation in prostate cancer cells: An in vitro study.Arch Biochem Biophys202642617929PubTator, text miningPubMed
Synthesis and Activity-Based Protein Profiling Identifies Aldo-Keto Reductase 1C3 as Target Protein of Myxoglucamides.Angew Chem Int Ed Engl202642573019PubTator, text miningPubMed
Integrated computational and in vitro investigation to explore the preliminary anti-proliferative and anti-mitotic potential of γ-oryzanol against breast cancer.Naunyn Schmiedebergs Arch Pharmacol202642525294PubTator, text miningPubMed
Naringin sensitizes nasopharyngeal carcinoma cells to paclitaxel by inducing AKR1C3 expression.J Int Med Res202642523162PubTator, text miningPubMed

1 to 10 of 2,828

See all 2,828 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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