Gene · 8644
AKR1C3: aldo-keto reductase family 1 member C3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. AKR1C3: aldo-keto reductase family 1 member C3. Genes, record 8644. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8644
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P42330 | Aldo-keto reductase family 1 member C3 | 323 | 67 | Ensembl, GeneID, HGNC |
Source UniProt
Patents34
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37069 | P42330 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10332 | P42330 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10332 | P42330 | Espacenet |
| JP 2025081326 A | 2025-05-27 | 37 | P42330 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3973 | P42330 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 24365 | P42330 | Espacenet |
| JP 2025024198 A | 2025-02-19 | 9010 | P42330 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 24365 | P42330 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 24365 | P42330 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 3973 | P42330 | Espacenet |
1 to 10 of 34
See all 34 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,514
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | AKR1C3 papers | Newest fiscal year |
|---|---|---|---|
| P30ES013508 | Center of Excellence in Environmental Toxicology | 86 | 2025 |
| P01CA163227 | Androgen Receptor Action in Castration Resistant Prostate Cancer | 28 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 23 | 2025 |
| R01CA172382 | Elucidating a novel molecular biomarker for castration-resistant prostate cancer | 11 | 2025 |
| T32ES019851 | Translational Research Training Program in Environmental Health Sciences | 10 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 9 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| R01GM086596 | Activation of androgen biosynthesis and drug metabolism by cytochrome b5 | 8 | 2025 |
| UL1TR001881 | UCLA Clinical and Translational Science Institute | 8 | 2025 |
1 to 10 of 1,514Source NIH's project files
See all 1,514 nih grantsPapers2,828
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Network toxicology and machine learning analysis of MC-LR-associated hepatocellular carcinoma. | J Environ Sci Health B | 2026 | 42811799 | PubTator, text mining | PubMed |
| Metabolomics and network pharmacology identify three key bioactive organic acid metabolites in Amomum tsao-ko. | Genomics | 2026 | 42764030 | PubTator, text mining | PubMed |
| Integrating target prediction and transcriptomic analysis identifies the AKR1C2-KRT8 axis in rotenone-induced dopaminergic neuron injury. | Brain Res Bull | 2026 | 42679909 | PubTator, text mining | PubMed |
| Integrated computational analysis prioritizes candidate targets and pathways linking ochratoxin A exposure to hepatocellular carcinoma. | PLoS One | 2026 | 42672059 | PubTator, text mining | PubMed |
| Triphala Targets the SLC7A11-GSH-GPX4 Axis to Trigger Ferroptosis in Oral Cancer: An Integrated Network Pharmacology, Molecular Docking, and Experimental Validation Study. | Chem Biol Drug Des | 2026 | 42644728 | PubTator, text mining | PubMed |
| Identification of candidate macrophage-ferroptosis crosstalk genes associated with immune infiltration in myocardial infarction: A bioinformatics analysis. | PLoS One | 2026 | 42640988 | PubTator, text mining | PubMed |
| Cotinine enhances androgen receptor stability and promotes androgen-dependent proliferation in prostate cancer cells: An in vitro study. | Arch Biochem Biophys | 2026 | 42617929 | PubTator, text mining | PubMed |
| Synthesis and Activity-Based Protein Profiling Identifies Aldo-Keto Reductase 1C3 as Target Protein of Myxoglucamides. | Angew Chem Int Ed Engl | 2026 | 42573019 | PubTator, text mining | PubMed |
| Integrated computational and in vitro investigation to explore the preliminary anti-proliferative and anti-mitotic potential of γ-oryzanol against breast cancer. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42525294 | PubTator, text mining | PubMed |
| Naringin sensitizes nasopharyngeal carcinoma cells to paclitaxel by inducing AKR1C3 expression. | J Int Med Res | 2026 | 42523162 | PubTator, text mining | PubMed |
1 to 10 of 2,828
See all 2,828 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8644
GET https://conductscience.org/api/genes/v1/8644/patents?page=2