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Gene · 8647

ABCB11: ATP binding cassette subfamily B member 11

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ABCB11: ATP binding cassette subfamily B member 11. Genes, record 8647. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8647

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Gene

Symbol
ABCB11
HGNC
Name
ATP binding cassette subfamily B member 11
HGNC
NCBI Gene ID
8647
NCBI Gene
HGNC ID
HGNC:42
HGNC
Ensembl
ENSG00000073734
NCBI Gene
Aliases
ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95342Bile salt export pump1,3218Ensembl, GeneID, HGNC

Source UniProt

Patents102

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4750895 A12026-06-037O95342Espacenet
JP 2026067851 A2026-04-2181O95342Espacenet
US 12508234 B22025-12-303O95342Espacenet
EP 4650780 A22025-11-1919668O95342Espacenet
JP 2025169942 A2025-11-14865O95342Espacenet
EP 4640849 A22025-10-294081O95342Espacenet
EP 4641201 A22025-10-2925479O95342Espacenet
JP 2025529142 A2025-09-04189O95342Espacenet
JP 2025525390 A2025-08-053650O95342Espacenet
US 12371689 B22025-07-29189O95342Espacenet

1 to 10 of 102

See all 102 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,737

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleABCB11 papersNewest fiscal year
P30DK034989Yale Liver Center282025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease252025
U01DK062453Colorado Center of Childhood Liver Disease ResearchNetwork192025
R35GM122576Mechanisms of Altered Hepatic Transport: Impact on Drug Therapy162025
P30DK026743UCSF Liver Center142025
U01DK062497Clinical Center for Cholestatic Liver Disease in Children122025
ZIABC005562Xenobiotic receptors122025
P30CA021765Cancer Center Support Grant (CCSG)102025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)102025
U01DK062481Advancing our Understanding of Rare Pediatric Liver Diseases102025

1 to 10 of 1,737Source NIH's project files

See all 1,737 nih grants

Papers3,310

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling.J Ethnopharmacol202742503322PubTator, text miningPubMed
Machine learning prediction of bile salt export pump inhibition with Boruta feature selection in imbalanced data.Front Pharmacol202642781341PubTator, text miningPubMed
Duodenal fluid analysis of 13 patients with progressive familial intrahepatic cholestasis type 2 from a single institution.Medicine (Baltimore)202642760696PubTator, text miningPubMed
Novel genetic variants and atypical phenotypes in pediatric progressive familial intrahepatic cholestasis.Pediatr Res202642754724PubTator, text miningPubMed
Genetic Spectrum of Cholestasis in Tunisia and Diagnostic Yield of Next-Generation Sequencing: Case Series of 70 Patients.Clin Genet202642742065PubTator, text miningPubMed
Mechanism of FXR signaling: from liver inflammation to hepatocellular carcinoma.Biochem Biophys Rep202642699277PubTator, text miningPubMed
Saxifraga umbellulata Attenuates Cholestatic Liver Injury and Modulates Farnesoid X Receptor-Related Bile Acid Homeostasis.Pharmazie202642695244PubTator, text miningPubMed
In Vitro Three-Dimensional Human Liver Model for Drug-Induced Liver and Bile Duct Injury Prediction.Toxics202642647006PubTator, text miningPubMed
Prediction of bile salt export pump inhibition using biomimetic chromatographic descriptors: Integrating membrane affinity and protein binding.ADMET DMPK202642633372PubTator, text miningPubMed
Progressive familial intrahepatic cholestasis disease burden and clinical approaches: a systematic review.J Comp Eff Res202642616472PubTator, text miningPubMed

1 to 10 of 3,310

See all 3,310 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8647

GET https://conductscience.org/api/genes/v1/8647/patents?page=2