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Gene · 8648

NCOA1: nuclear receptor coactivator 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NCOA1: nuclear receptor coactivator 1. Genes, record 8648. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8648

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Gene

Symbol
NCOA1
HGNC
Name
nuclear receptor coactivator 1
HGNC
NCBI Gene ID
8648
NCBI Gene
HGNC ID
HGNC:7668
HGNC
Ensembl
ENSG00000084676
NCBI Gene
Aliases
F-SRC-1, KAT13A, NCoA-1, RIP160, SRC1, bHLHe42, bHLHe74
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15788Nuclear receptor coactivator 11,441303Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456089Q15788Espacenet
JP 2026004568 A2026-01-1456092Q15788Espacenet
EP 4650780 A22025-11-195348Q15788Espacenet
EP 4641201 A22025-10-294938Q15788Espacenet
JP 2025147176 A2025-10-0615343Q15788Espacenet
JP 2025517969 A2025-06-124938Q15788Espacenet
JP 2025517970 A2025-06-125348Q15788Espacenet
JP 2025028160 A2025-02-2815343Q15788Espacenet
KR 1020250010750 A2025-01-2115343Q15788Espacenet
JP 2024109657 A2024-08-1415182Q15788Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,941

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNCOA1 papersNewest fiscal year
R01HD007857Sex Hormone Receptor Component And The Cell Genome352025
R01HD008188Reproductive Hormones - Biological and Molecular Actions322025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant292025
P30CA008748Cancer Center Support Grant192025
P30CA021765Cancer Center Support Grant (CCSG)172025
P30CA016672Cancer Center Support Grant122025
R35GM118041Regulation of xenobiotic receptors PXR and CAR, and CYP3A: implications in drug disposition102025
P30CA006973Regional Oncology Research Center92025
P30DK056338Texas Medical Center Digestive Diseases Center82025
ZIABC011387Studies of gene fusions in rhabdomyosarcoma72025

1 to 10 of 1,941Source NIH's project files

See all 1,941 nih grants

Papers3,138

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Panaxytriol up-regulates CYP2B6 expression through PXR and CAR and their interactions with RXRα and SRC-1.J Ethnopharmacol202642777982PubTator, text miningPubMed
Whole-exome sequencing-centered genetic evaluation for early-onset obesity in Chinese children: a retrospective single-center cohort.Transl Pediatr202642724349PubTator, text miningPubMed
Targeting host lipogenesis with a diarylamide inhibitor disrupts SARS-CoV-2 replication.iScience202642603033PubTator, text miningPubMed
Uterine tumour resembling ovarian sex cord tumour (utrosct) associated with ctnnb1, pten and other gene mutations: Expanding the molecular landscape.Virchows Arch202642593492PubTator, text miningPubMed
Dual MDM2 and PPARG regulatory axes mediate the antiepileptic effects of Gouteng: An integration of bioinformatics, network pharmacology, machine learning, molecular docking, and MD simulations.Neuropharmacology202642575349PubTator, text miningPubMed
Integrated Clinicopathologic and Multiomic Profiling Reveals MEIS1-Rearranged Sarcoma as a Distinct Entity With 2 Prognostic Subgroups.Mod Pathol202642471200PubTator, text miningPubMed
Biphenotypic Sinonasal Sarcomas with Recurrent PAX3::FOXO6 Gene Fusion.Head Neck Pathol202642446761PubTator, text miningPubMed
Elevated ESR2 and BRCA1 gene expression in adenomyosis associated with endometrial cancer: a pilot study.Gynecol Endocrinol202642329179PubTator, text miningPubMed
Evaluation of the Ligand-Dependent Coactivator Recruitment of the Nuclear Receptor Pregnane X Receptor Using Its Three-Alanine Residues-Inserted Mutant.Biol Pharm Bull202642324158PubTator, text miningPubMed
Nonsteroidal Mineralocorticoid Receptor Antagonists in Heart Failure: Mechanistic Basis, Clinical Evidence, and Therapeutic Integration.Drugs Drug Candidates202642305634PubTator, text miningPubMed

1 to 10 of 3,138

See all 3,138 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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