Gene · 8650
NUMB: NUMB endocytic adaptor protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NUMB: NUMB endocytic adaptor protein. Genes, record 8650. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8650
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49757 | Protein numb homolog | 651 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 56443 | P49757 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 56452 | P49757 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7029 | P49757 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7029 | P49757 | Espacenet |
| US 12186353 B2 | 2025-01-07 | 1 | P49757 | Espacenet |
| EP 4484957 A1 | 2025-01-01 | 151 | P49757 | Espacenet |
| WO 2023162878 A | 2023-08-31 | 151 | P49757 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 59184 | P49757 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 59191 | P49757 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 162155 | P49757 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,661
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NUMB papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 14 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| P50AA011999 | Southern California Research Center for ALPD and Cirrhosis | 7 | 2025 |
| R24AA012885 | Integrative Liver Cell Core | 6 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 5 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 5 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 5 | 2025 |
| P30CA023168 | Cancer Center Support Grant | 4 | 2025 |
| P30CA138292 | Winship Cancer Institute Cancer Center Support Grant | 4 | 2025 |
| P20GM103418 | Kansas IDeA Network of Biomedical Research Excellence 5 | 3 | 2025 |
1 to 10 of 1,661Source NIH's project files
See all 1,661 nih grantsPapers2,413
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| E3 Ubiquitin Ligase RNF126 Promotes Ovarian Cancer Progression and Cisplatin Resistance Through Targeting Numb/Notch1 Axis. | Front Biosci (Landmark Ed) | 2026 | 42689967 | PubTator, text mining | PubMed |
| MDM2/Notch-Ferroptosis crosstalk in cancer: metabolic rewiring, immune evasion, and organ-specific metastasis. | PeerJ | 2026 | 42371550 | PubTator, text mining | PubMed |
| Tumoral switch in NUMB splicing changes essential transcription pathways and induces malignant properties in tumour cells. | Genome Biol | 2026 | 42343463 | PubTator, text mining | PubMed |
| Numb mitigates intestinal epithelial cell senescence induced by radiation through a PLK1-dependent pathway. | Sci Rep | 2026 | 41896293 | PubTator, text mining | PubMed |
| The role of Notch signalling and its crosstalk with oestrogen receptor signalling in breast cancer. | Cancer Metastasis Rev | 2026 | 41894035 | PubTator, text mining | PubMed |
| Competition for the conserved branch point sequence influences physiological outcomes in pre-mRNA splicing. | Elife | 2026 | 41860977 | PubTator, text mining | PubMed |
| The JMJD family histone demethylases: structure, mechanism of action, diseases and therapeutic targets. | Mol Biomed | 2026 | 41857315 | PubTator, text mining | PubMed |
| O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy. | Cell Death Dis | 2026 | 41833953 | PubTator, text mining | PubMed |
| ROCK signaling at the crossroads of redox stress, mitochondrial dynamics, and metabolic disease. | Redox Biol | 2026 | 41791289 | PubTator, text mining | PubMed |
| Liquid-liquid phase separation in neural development. | Cell Mol Life Sci | 2026 | 41790295 | PubTator, text mining | PubMed |
1 to 10 of 2,413
See all 2,413 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8650
GET https://conductscience.org/api/genes/v1/8650/patents?page=2