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Gene · 8650

NUMB: NUMB endocytic adaptor protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NUMB: NUMB endocytic adaptor protein. Genes, record 8650. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8650

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Gene

Symbol
NUMB
HGNC
Name
NUMB endocytic adaptor protein
HGNC
NCBI Gene ID
8650
NCBI Gene
HGNC ID
HGNC:8060
HGNC
Ensembl
ENSG00000133961
NCBI Gene
Aliases
C14orf41, S171, c14_5527
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49757Protein numb homolog6512Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456443P49757Espacenet
JP 2026004568 A2026-01-1456452P49757Espacenet
EP 4641201 A22025-10-297029P49757Espacenet
JP 2025517969 A2025-06-127029P49757Espacenet
US 12186353 B22025-01-071P49757Espacenet
EP 4484957 A12025-01-01151P49757Espacenet
WO 2023162878 A2023-08-31151P49757Espacenet
US 11446398 B22022-09-2059184P49757Espacenet
US 11446398 B22022-09-2059191P49757Espacenet
JP 2022524081 A2022-04-27162155P49757Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,661

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNUMB papersNewest fiscal year
P30CA016672Cancer Center Support Grant142025
P30CA008748Cancer Center Support Grant132025
P50AA011999Southern California Research Center for ALPD and Cirrhosis72025
R24AA012885Integrative Liver Cell Core62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA015704Cancer Center Support Grant52025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202852025
P30CA023168Cancer Center Support Grant42025
P30CA138292Winship Cancer Institute Cancer Center Support Grant42025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 532025

1 to 10 of 1,661Source NIH's project files

See all 1,661 nih grants

Papers2,413

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
E3 Ubiquitin Ligase RNF126 Promotes Ovarian Cancer Progression and Cisplatin Resistance Through Targeting Numb/Notch1 Axis.Front Biosci (Landmark Ed)202642689967PubTator, text miningPubMed
MDM2/Notch-Ferroptosis crosstalk in cancer: metabolic rewiring, immune evasion, and organ-specific metastasis.PeerJ202642371550PubTator, text miningPubMed
Tumoral switch in NUMB splicing changes essential transcription pathways and induces malignant properties in tumour cells.Genome Biol202642343463PubTator, text miningPubMed
Numb mitigates intestinal epithelial cell senescence induced by radiation through a PLK1-dependent pathway.Sci Rep202641896293PubTator, text miningPubMed
The role of Notch signalling and its crosstalk with oestrogen receptor signalling in breast cancer.Cancer Metastasis Rev202641894035PubTator, text miningPubMed
Competition for the conserved branch point sequence influences physiological outcomes in pre-mRNA splicing.Elife202641860977PubTator, text miningPubMed
The JMJD family histone demethylases: structure, mechanism of action, diseases and therapeutic targets.Mol Biomed202641857315PubTator, text miningPubMed
O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy.Cell Death Dis202641833953PubTator, text miningPubMed
ROCK signaling at the crossroads of redox stress, mitochondrial dynamics, and metabolic disease.Redox Biol202641791289PubTator, text miningPubMed
Liquid-liquid phase separation in neural development.Cell Mol Life Sci202641790295PubTator, text miningPubMed

1 to 10 of 2,413

See all 2,413 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8650

GET https://conductscience.org/api/genes/v1/8650/patents?page=2