ConductScience.org, home

Library / Genes

PDE5A: phosphodiesterase 5A

1 protein, 50 patents, 13 drugs, 673 trials, 2,313 NIH grants and 6,240 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPDE5AHGNC
Namephosphodiesterase 5AHGNC
NCBI Gene ID8654NCBI Gene
HGNC IDHGNC:8784HGNC
EnsemblENSG00000138735NCBI Gene
AliasesCGB-PDE, CN5A, PDE5NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O76074cGMP-specific 3',5'-cyclic phosphodiesterase87550Ensembl, GeneID, HGNCUniProt

Patents 50

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026089002 A2026-04-301O76074Espacenet
JP 2026509481 A2026-03-195O76074Espacenet
JP 2026004568 A2026-01-1457752O76074Espacenet
KR 1020250164239 A2025-11-245O76074Espacenet
JP 2025537861 A2025-11-2021O76074Espacenet
EP 4641201 A22025-10-297019O76074Espacenet
KR 1020250126156 A2025-08-2221O76074Espacenet
JP 2025122052 A2025-08-2071O76074Espacenet
WO 2025144887 A12025-07-0315O76074Espacenet
JP 2025517969 A2025-06-127019O76074Espacenet

Drugs 13

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AVANAFILCHEMBL1963681Phosphodiesterase 5A inhibitorINHIBITORChEMBL
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
GISADENAFILCHEMBL1928262Phosphodiesterase 5A inhibitorINHIBITORChEMBL
IBUDILASTCHEMBL19449Phosphodiesterase 5A inhibitorINHIBITORChEMBL
PENTOXIFYLLINECHEMBL6283',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
PF-00489791CHEMBL4210847Phosphodiesterase 5A inhibitorINHIBITORChEMBL
PF-03049423CHEMBL591501Phosphodiesterase 5A inhibitorINHIBITORChEMBL
SILDENAFILCHEMBL192Phosphodiesterase 5A inhibitorINHIBITORChEMBL
SILDENAFIL CITRATECHEMBL1737Phosphodiesterase 5A inhibitorINHIBITORChEMBL
TADALAFILCHEMBL779Phosphodiesterase 5A inhibitorINHIBITORChEMBL

Trials 673

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07602608TADALAFILPHASE4ClinicalTrials.gov
NCT07601646SILDENAFILPHASE2ClinicalTrials.gov
NCT07576335TADALAFILPHASE2ClinicalTrials.gov
NCT07574268TADALAFILPHASE4ClinicalTrials.gov
NCT07537855TADALAFILPHASE2ClinicalTrials.gov
NCT07508358SILDENAFIL CITRATEPHASE1ClinicalTrials.gov
NCT07462260SILDENAFILPHASE2/PHASE3ClinicalTrials.gov
NCT07391579SILDENAFILPHASE4ClinicalTrials.gov
NCT07391579TADALAFILPHASE4ClinicalTrials.gov
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov

NIH grants 2313

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
T32HL007227Pathophysiology of Myocardial Disease202,025NIH's project files
R01EY010843Regulation of Retinal cGMP-Phosphodiesterases132,025NIH's project files
P30CA008748Cancer Center Support Grant102,025NIH's project files
R01HD072929Optimal Oxygenation in Neonatal Lung Injury82,025NIH's project files
P30CA056036Translational Research in Cancer62,025NIH's project files
T32HL007111Cardiovasology62,025NIH's project files
P30CA016059Massey Cancer Center - Cancer Center Support Grant52,025NIH's project files
R01HL124021An endothelial-fibroblast axis connecting senescence to amino acid metabolism for control of vascular stiffness in PAH52,025NIH's project files
P20GM113226Hepatobiology and Toxicology COBRE42,025NIH's project files
T32HL007915Training in Molecular Therapeutics for Pediatric Cardiology42,025NIH's project files

Papers 6240

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42765427PubTator, text miningPubMed
42764647PubTator, text miningPubMed
42740929PubTator, text miningPubMed
42732925PubTator, text miningPubMed
42725809PubTator, text miningPubMed
42714004PubTator, text miningPubMed
42679515PubTator, text miningPubMed
42663685PubTator, text miningPubMed
42638569PubTator, text miningPubMed
42622135PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license