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Gene · 8658

TNKS: tankyrase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TNKS: tankyrase. Genes, record 8658. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8658

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Gene

Symbol
TNKS
HGNC
Name
tankyrase
HGNC
NCBI Gene ID
8658
NCBI Gene
HGNC ID
HGNC:11941
HGNC
Ensembl
ENSG00000173273
NCBI Gene
Aliases
ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1, pART5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95271Poly [ADP-ribose] polymerase tankyrase-11,32742Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194767O95271Espacenet
EP 4641201 A22025-10-294339O95271Espacenet
JP 2025517969 A2025-06-124339O95271Espacenet
JP 2025517970 A2025-06-124767O95271Espacenet
JP 2024123008 A2024-09-108606O95271Espacenet
US 12023385 B22024-07-0229O95271Espacenet
EP 4119552 A12023-01-1843O95271Espacenet
US 11446398 B22022-09-2086662O95271Espacenet
JP 2022524081 A2022-04-27189633O95271Espacenet
US 11311609 B22022-04-2643O95271Espacenet

1 to 10 of 38

See all 38 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
2X-121CHEMBL3644587Tankyrase 1/2 inhibitorINHIBITOR

Source ChEMBL

Trials4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT066812202X-121PHASE1/PHASE2ClinicalTrials.gov
NCT038788492X-121PHASE2ClinicalTrials.gov
NCT035628322X-121PHASE2ClinicalTrials.gov
NCT016181362X-121PHASE1/PHASE2ClinicalTrials.gov

NIH grants1,651

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTNKS papersNewest fiscal year
P30CA016672Cancer Center Support Grant172025
P30CA008748Cancer Center Support Grant112025
P30CA014051Cancer Center Support (Core) Grant82025
T32CA009110Training in Areas Fundamental to Cancer Research82025
P20GM113117Chemical Biology of Infectious Disease62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)62025
P30CA023108Cancer Center Support Grant62025
P30CA046934University of Colorado Cancer Center Support Grant62025
P30CA047904Cancer Center Support Grant62025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center62025

1 to 10 of 1,651Source NIH's project files

See all 1,651 nih grants

Papers2,155

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Telomeres in mitosis: organization and dynamics.Nucleus202642758105PubTator, text miningPubMed
An Integrated Consensus Machine Learning and Structure-Based Workflow for the Discovery of Novel Tankyrase 1 Inhibitors.Pharmaceuticals (Basel)202642653805PubTator, text miningPubMed
Tankyrase-2 regulates adipocyte differentiation through AMPK/mTOR signaling.FEBS J202642563506PubTator, text miningPubMed
Replacement soaking for human tankyrase 2 enables studies on substrate analogues and inhibitors.Acta Crystallogr D Struct Biol202642522928PubTator, text miningPubMed
Disrupting the tumor-associated TNKS-USP25 protein-protein interface in cancer: structural basis, druggability, and therapeutic opportunities.RSC Adv202642441110PubTator, text miningPubMed
Tankyrase inhibition restores chemosensitivity in triple-negative breast cancer cells by disrupting TFEB/β-Catenin/ABCG2 axis.Mol Biol Rep202642423804PubTator, text miningPubMed
FMRP-Mediated Proteasome Regulation: A Novel Mechanism in ALS Pathology.FASEB J202642363684PubTator, text miningPubMed
Synthesis and Biological Evaluation of Novel Flavone-Sulfonamide Hybrid Derivatives as Potential Anticancer Agents.Curr Med Chem202642300302PubTator, text miningPubMed
Dual PARP/Tankyrase Inhibition Enhances Antitumor Efficacy in PTEN-Deficient Endometrial Cancer.J Cell Mol Med202642286682PubTator, text miningPubMed
Targeting VAMP5 suppresses PLK1-driven growth of gliomas with high NDRG4 expression.J Neurooncol202642257837PubTator, text miningPubMed

1 to 10 of 2,155

See all 2,155 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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