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IRS2: insulin receptor substrate 2

1 protein, 39 patents, 0 drugs, 0 trials, 2,728 NIH grants and 4,641 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIRS2HGNC
Nameinsulin receptor substrate 2HGNC
NCBI Gene ID8660NCBI Gene
HGNC IDHGNC:6126HGNC
EnsemblENSG00000185950NCBI Gene
AliasesIRS-2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9Y4H2Insulin receptor substrate 21,3382Ensembl, GeneID, HGNCUniProt

Patents 39

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449906Q9Y4H2Espacenet
EP 4650780 A22025-11-199699Q9Y4H2Espacenet
EP 4641201 A22025-10-299955Q9Y4H2Espacenet
EP 4641202 A22025-10-295645Q9Y4H2Espacenet
JP 2025517969 A2025-06-129955Q9Y4H2Espacenet
JP 2025517970 A2025-06-129699Q9Y4H2Espacenet
KR 1020250017231 A2025-02-045645Q9Y4H2Espacenet
US 12006548 B22024-06-11484Q9Y4H2Espacenet
US 11987613 B22024-05-211Q9Y4H2Espacenet
US 11726090 B22023-08-1512Q9Y4H2Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2728

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK036836Diabetes Research Center372,025NIH's project files
P30CA016672Cancer Center Support Grant242,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)222,025NIH's project files
P30CA008748Cancer Center Support Grant192,025NIH's project files
R01DK067536Role of IGF-1 and insulin receptors beta-cell survival132,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA72,025NIH's project files
P30CA077598Cancer Center Support Grant72,025NIH's project files
P30DK072476Pennington/Louisiana NORC72,025NIH's project files
R01AA011431FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays72,025NIH's project files
T32DK007260Training Grant in Diabetes and Metabolism72,025NIH's project files

Papers 4641

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42780728PubTator, text miningPubMed
42723547PubTator, text miningPubMed
42696501PubTator, text miningPubMed
42692008PubTator, text miningPubMed
42688698PubTator, text miningPubMed
42621150PubTator, text miningPubMed
42575435PubTator, text miningPubMed
42549336PubTator, text miningPubMed
42511968PubTator, text miningPubMed
42491925PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license