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Gene · 8671

SLC4A4: solute carrier family 4 member 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC4A4: solute carrier family 4 member 4. Genes, record 8671. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8671

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Gene

Symbol
SLC4A4
HGNC
Name
solute carrier family 4 member 4
HGNC
NCBI Gene ID
8671
NCBI Gene
HGNC ID
HGNC:11030
HGNC
Ensembl
ENSG00000080493
NCBI Gene
Aliases
HNBC1, KNBC, NBC1, NBC2, NBCe1, NBCe1-A, PMBED, PRTAO, SLC4A5, hhNMC, kNBC1, pNBC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y6R1Electrogenic sodium bicarbonate cotransporter 11,0791Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026090543 A2026-06-02819Q9Y6R1Espacenet
JP 2026004568 A2026-01-1464604Q9Y6R1Espacenet
EP 4650780 A22025-11-192361Q9Y6R1Espacenet
EP 4640849 A22025-10-29277Q9Y6R1Espacenet
EP 4641201 A22025-10-291935Q9Y6R1Espacenet
JP 2025529142 A2025-09-044254Q9Y6R1Espacenet
WO 2025169993 A2025-08-148Q9Y6R1Espacenet
US 12371689 B22025-07-294254Q9Y6R1Espacenet
JP 2025519096 A2025-06-24277Q9Y6R1Espacenet
JP 2025517969 A2025-06-121935Q9Y6R1Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,054

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC4A4 papersNewest fiscal year
ZIADE000735Ca2+ signaling and HCO3- secretion by exocrine glands72025
P30DK034854Integrated Epithelial and Muscosal Biology42025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology42025
P30ES009089Center for Environmental Health in Northern Manhattan42025
P30CA076292Moffitt Cancer Center Support Grant32025
P30DK034987Center for Gastrointestinal Biology and Disease32025
P30DK063491Diabetes Research Center (DRC)32025
P30EY003176UC Berkeley Vision Science CORE32025
P50HD103555Baylor College of Medicine Intellectual and Developmental Disabilities Research Center32025
R01DK057061Calcium Dynamics in Interstitial Cells of Cajal32025

1 to 10 of 1,054Source NIH's project files

See all 1,054 nih grants

Papers1,389

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Blood-Derived DNA Methylation Biomarkers Predict Diabetic Kidney Disease and Map to Epigenomic Remodeling in Renal Cells.Diabetes202642821458PubTator, text miningPubMed
Stroke drives glioma progression through the emergence of tumor-associated astrocytes with reduced Ca2+ activity.Nat Cancer202642791388PubTator, text miningPubMed
Mechanistic insights into Na+-dependent HCO3- transport by NBCn2 (SLC4A10).Structure202642641598PubTator, text miningPubMed
Lactylation of EIF4A3 mediates sustained circPTK2 biogenesis to drive prostate cancer metastasis.Cancer Lett202642595075PubTator, text miningPubMed
Sex differences in renal acid-base regulation.Curr Opin Nephrol Hypertens202642396848PubTator, text miningPubMed
Gill ionocytes of the Lake Magadi tilapia (Oreochromis Alcolapia grahami), an extremophilic teleost native to a highly alkaline environment.Cell Tissue Res202642334627PubTator, text miningPubMed
Uncovering genes driving developmental stage progression in prostate cancer through spatial transcriptomics.Genes Dis202642290662PubTator, text miningPubMed
Therapeutic Potential of Allomyrinasin in Oral Squamous Cell Carcinoma via Decreased NBC Activity.Pharmaceutics202642198315PubTator, text miningPubMed
Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread.Sci Adv202641861004PubTator, text miningPubMed
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema.Ann Clin Transl Neurol202641841191PubTator, text miningPubMed

1 to 10 of 1,389

See all 1,389 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8671

GET https://conductscience.org/api/genes/v1/8671/patents?page=2