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Gene · 868

CBLB: Cbl proto-oncogene B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CBLB: Cbl proto-oncogene B. Genes, record 868. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/868

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Gene

Symbol
CBLB
HGNC
Name
Cbl proto-oncogene B
HGNC
NCBI Gene ID
868
NCBI Gene
HGNC ID
HGNC:1542
HGNC
Ensembl
ENSG00000114423
NCBI Gene
Aliases
ADMIO3, Cbl-b, Nbla00127, RNF56
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13191E3 ubiquitin-protein ligase CBL-B98227Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440137Q13191Espacenet
EP 4650780 A22025-11-1911093Q13191Espacenet
EP 4641201 A22025-10-2911542Q13191Espacenet
JP 2025517969 A2025-06-1211542Q13191Espacenet
JP 2025517970 A2025-06-1211093Q13191Espacenet
JP 2025066723 A2025-04-2319Q13191Espacenet
JP 2025508061 A2025-03-2125Q13191Espacenet
JP 2025032204 A2025-03-1125882Q13191Espacenet
EP 4490152 A12025-01-1525Q13191Espacenet
KR 1020250004951 A2025-01-0825Q13191Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,313

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCBLB papersNewest fiscal year
ZIABC010977Cbl Proteins as Regulators of Tyrosine Kinase Signaling162025
ZIAHG200318Investigations of Methylmalonic Acidemia and Related Disorders122025
ZIASC007263Activating Cell Death Pathways in Breast Cancer Cells122025
P30CA008748Cancer Center Support Grant102025
R01DK045776B12 Trafficking and Inherited Defects102025
T32CA009476Cancer Biology Training Program102025
P30CA036727Buffett Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant72025
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR62025
P30CA016058Cancer Center Support Grant42025

1 to 10 of 1,313Source NIH's project files

See all 1,313 nih grants

Papers1,946

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting intracellular immune regulatory molecules for cancer immunotherapy in solid tumors.Crit Rev Oncol Hematol202642732787PubTator, text miningPubMed
Discovery of Cbl-b Targeting Cyclic Peptide Ligands by Phage Display.Org Lett202642726242PubTator, text miningPubMed
Pushing the boundaries of virtual screening scale of combinatorial spaces with the V-SYNTHES approach.NPJ Drug Discov202642686876PubTator, text miningPubMed
β-Hydroxy-β-methylbutyrate (HMB) Counteracts Atrophy and Restores Circadian Rhythms in Myotubes.Int J Mol Sci202642511533PubTator, text miningPubMed
Correction: miR-1323 promotes cell migration in lung adenocarcinoma by targeting Cbl-b and is an early prognostic biomarker.Front Oncol202642491279PubTator, text miningPubMed
CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16INK4A in Controlling TCR-Dependent and Independent CD8 T Cell Expansion.Eur J Immunol202642345443PubTator, text miningPubMed
Tumor Treating Fields modulate apoptotic and immune programs in T-cell acute lymphoblastic leukemia cell lines.Exp Ther Med202642305707PubTator, text miningPubMed
Identification of ubiquitination-related biomarkers in osteoarthritis: Combining transcriptome and Mendelian randomization analysis.SLAS Technol202642285256PubTator, text miningPubMed
N6-methyladenosine modification of CBLB affects LPS-induced endoplasmic reticulum stress in alveolar epithelial cells.Cent Eur J Immunol202642245124PubTator, text miningPubMed
Ablation of Cbl-b in ROBO1 CAR-NK92 Cells Enhances Their Antitumor Efficacy.Hum Gene Ther202642204417PubTator, text miningPubMed

1 to 10 of 1,946

See all 1,946 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/868

GET https://conductscience.org/api/genes/v1/868/patents?page=2