Gene · 868
CBLB: Cbl proto-oncogene B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CBLB: Cbl proto-oncogene B. Genes, record 868. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/868
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13191 | E3 ubiquitin-protein ligase CBL-B | 982 | 27 | Ensembl, GeneID, HGNC |
Source UniProt
Patents43
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 40137 | Q13191 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 11093 | Q13191 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 11542 | Q13191 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 11542 | Q13191 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 11093 | Q13191 | Espacenet |
| JP 2025066723 A | 2025-04-23 | 19 | Q13191 | Espacenet |
| JP 2025508061 A | 2025-03-21 | 25 | Q13191 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 25882 | Q13191 | Espacenet |
| EP 4490152 A1 | 2025-01-15 | 25 | Q13191 | Espacenet |
| KR 1020250004951 A | 2025-01-08 | 25 | Q13191 | Espacenet |
1 to 10 of 43
See all 43 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,313
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CBLB papers | Newest fiscal year |
|---|---|---|---|
| ZIABC010977 | Cbl Proteins as Regulators of Tyrosine Kinase Signaling | 16 | 2025 |
| ZIAHG200318 | Investigations of Methylmalonic Acidemia and Related Disorders | 12 | 2025 |
| ZIASC007263 | Activating Cell Death Pathways in Breast Cancer Cells | 12 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| R01DK045776 | B12 Trafficking and Inherited Defects | 10 | 2025 |
| T32CA009476 | Cancer Biology Training Program | 10 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P01AI091580 | Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR | 6 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,313Source NIH's project files
See all 1,313 nih grantsPapers1,946
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Targeting intracellular immune regulatory molecules for cancer immunotherapy in solid tumors. | Crit Rev Oncol Hematol | 2026 | 42732787 | PubTator, text mining | PubMed |
| Discovery of Cbl-b Targeting Cyclic Peptide Ligands by Phage Display. | Org Lett | 2026 | 42726242 | PubTator, text mining | PubMed |
| Pushing the boundaries of virtual screening scale of combinatorial spaces with the V-SYNTHES approach. | NPJ Drug Discov | 2026 | 42686876 | PubTator, text mining | PubMed |
| β-Hydroxy-β-methylbutyrate (HMB) Counteracts Atrophy and Restores Circadian Rhythms in Myotubes. | Int J Mol Sci | 2026 | 42511533 | PubTator, text mining | PubMed |
| Correction: miR-1323 promotes cell migration in lung adenocarcinoma by targeting Cbl-b and is an early prognostic biomarker. | Front Oncol | 2026 | 42491279 | PubTator, text mining | PubMed |
| CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16INK4A in Controlling TCR-Dependent and Independent CD8 T Cell Expansion. | Eur J Immunol | 2026 | 42345443 | PubTator, text mining | PubMed |
| Tumor Treating Fields modulate apoptotic and immune programs in T-cell acute lymphoblastic leukemia cell lines. | Exp Ther Med | 2026 | 42305707 | PubTator, text mining | PubMed |
| Identification of ubiquitination-related biomarkers in osteoarthritis: Combining transcriptome and Mendelian randomization analysis. | SLAS Technol | 2026 | 42285256 | PubTator, text mining | PubMed |
| N6-methyladenosine modification of CBLB affects LPS-induced endoplasmic reticulum stress in alveolar epithelial cells. | Cent Eur J Immunol | 2026 | 42245124 | PubTator, text mining | PubMed |
| Ablation of Cbl-b in ROBO1 CAR-NK92 Cells Enhances Their Antitumor Efficacy. | Hum Gene Ther | 2026 | 42204417 | PubTator, text mining | PubMed |
1 to 10 of 1,946
See all 1,946 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/868
GET https://conductscience.org/api/genes/v1/868/patents?page=2