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Gene · 8694

DGAT1: diacylglycerol O-acyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DGAT1: diacylglycerol O-acyltransferase 1. Genes, record 8694. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8694

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Gene

Symbol
DGAT1
HGNC
Name
diacylglycerol O-acyltransferase 1
HGNC
NCBI Gene ID
8694
NCBI Gene
HGNC ID
HGNC:2843
HGNC
Ensembl
ENSG00000185000
NCBI Gene
Aliases
ARAT, ARGP1, DGAT, DIAR7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75907Diacylglycerol O-acyltransferase 14885Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12600978 B22026-04-14355O75907Espacenet
JP 2026004568 A2026-01-1443723O75907Espacenet
US 12486470 B22025-12-0288O75907Espacenet
EP 4650780 A22025-11-1918676O75907Espacenet
US 12421523 B22025-09-2388O75907Espacenet
JP 2025529142 A2025-09-041249O75907Espacenet
US 12371689 B22025-07-291249O75907Espacenet
JP 2025517970 A2025-06-1218676O75907Espacenet
EP 4303288 A22024-01-1088O75907Espacenet
US 11859193 B22024-01-0288O75907Espacenet

1 to 10 of 73

See all 73 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD-7687CHEMBL4297354Diacylglycerol O-acyltransferase 1 inhibitorINHIBITORChEMBL
PRADIGASTATCHEMBL2364624Diacylglycerol O-acyltransferase 1 inhibitorINHIBITORChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04620161PRADIGASTATPHASE2ClinicalTrials.gov
NCT01811472PRADIGASTATPHASE22016-02-04ClinicalTrials.gov
NCT01594983PRADIGASTATPHASE2ClinicalTrials.gov
NCT01589237PRADIGASTATPHASE32016-11-15ClinicalTrials.gov
NCT01514461PRADIGASTATPHASE32015-06-03ClinicalTrials.gov
NCT01387958PRADIGASTATPHASE2ClinicalTrials.gov
NCT01146522PRADIGASTATPHASE1/PHASE2ClinicalTrials.gov

NIH grants1,307

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDGAT1 papersNewest fiscal year
R01DK045343Regional Fatty Acid Metabolism In Humans142025
P30DK026743UCSF Liver Center102025
R01DK040484FFA Metabolism in Different Types of Human Obesity92025
T32HL007343Postdoctoral Training in Arteriosclerosis Research82025
P30DK020572Michigan Diabetes Research Center (MDRC)72025
P30DK056341Washington University Nutrition Obesity Research Center72025
P30DK058404Molecular and Cellular Basis for Digestive Diseases72025
P30CA008748Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant52025
P30DK020579Diabetes Research Center52025

1 to 10 of 1,307Source NIH's project files

See all 1,307 nih grants

Papers2,292

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Role of HILPDA in Diseases: Mechanisms and Functional Insights.J Lipid Res202642810643PubTator, text miningPubMed
Function of HIF-1α in Regulating Sphingolipid Metabolism and Alleviating Oxidative Stress Damage in Callosobruchus chinensis Under Hypoxia.Insects202642783271PubTator, text miningPubMed
Bovine viral diarrhea virus (BVDV) relies on cellular lipid droplet biogenesis and lipolysis to provide energy for viral replication.Vet Res202642763408PubTator, text miningPubMed
Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria.Nat Commun202642749740PubTator, text miningPubMed
From physiological homeostasis to pathological injury: Cell-specific functions, imbalance mechanisms, and disease biomarker value of brain lipid droplets.Int Immunopharmacol202642721506PubTator, text miningPubMed
Lyssavirus Nucleoprotein Induces GPAT4-Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication.Adv Sci (Weinh)202642717496PubTator, text miningPubMed
Cutaneous papillomaviruses infection rewires fatty-acid metabolism.Front Cell Infect Microbiol202642688002PubTator, text miningPubMed
Advanced glycation end products drive blood-brain barrier lipid dysregulation via RAGE-ABCA1 signaling to promote neurovascular dysfunction in Alzheimer's disease.Mol Psychiatry202642686999PubTator, text miningPubMed
Global landscape of clinical trials and therapeutic targets in metabolic dysfunction-associated steatotic liver disease: an integrative multi-omics analysis.J Endocrinol Invest202642645756PubTator, text miningPubMed
A pan-genome perspective uncovers the core genetic basis and evolutionary adaptation of lipid synthesis and vesicular transport in Nannochloropsis.J Phycol202642615245PubTator, text miningPubMed

1 to 10 of 2,292

See all 2,292 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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