ConductScience.org, home

Gene · 8717

TRADD: TNFRSF1A associated via death domain

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. TRADD: TNFRSF1A associated via death domain. Genes, record 8717. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8717

On this page

Gene

Symbol
TRADD
HGNC
Name
TNFRSF1A associated via death domain
HGNC
NCBI Gene ID
8717
NCBI Gene
HGNC ID
HGNC:12030
HGNC
Ensembl
ENSG00000102871
NCBI Gene
Aliases
Hs.89862
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15628Tumor necrosis factor receptor type 1-associated DEATH domain protein3127Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-196631Q15628Espacenet
JP 2025147176 A2025-10-0616517Q15628Espacenet
JP 2025517970 A2025-06-126631Q15628Espacenet
JP 2025028160 A2025-02-2816517Q15628Espacenet
KR 1020250010750 A2025-01-2116517Q15628Espacenet
JP 2024123008 A2024-09-108726Q15628Espacenet
JP 2024109657 A2024-08-1416356Q15628Espacenet
US 11708396 B22023-07-252030Q15628Espacenet
US 11701379 B22023-07-18204Q15628Espacenet
US 11446398 B22022-09-2089125Q15628Espacenet

1 to 10 of 46

See all 46 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,604

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRADD papersNewest fiscal year
P30CA016672Cancer Center Support Grant202025
ZIASC010376TNF Signaling, Cell Death and Cancer92025
ZIABC010783Inflammation, Macrophage Differentiation, and Cancer52025
P01CA019014Viral Oncogenesis, Latency, and Replication42025
P30CA016056Roswell Park Cancer Center Support Grant42025
P30CA047904Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
ZIABC010440Protein Structure, Stability, and Amyloid Formation42025
ZIABC010441Biomolecular Recognition and Binding Mechanisms42025
ZIDAR041180Clinical Support Services for the NIAMS Intramural Research Program42025

1 to 10 of 1,604Source NIH's project files

See all 1,604 nih grants

Papers2,847

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Jaceidin Inhibits Proliferation and Promotes Apoptosis in Oral Squamous Cell Carcinoma Cells by Regulating Survivin and AKT/ERK Signaling Pathways.Int J Mol Sci202642737771PubTator, text miningPubMed
Structural characterization of PAMK and its protective effect against thymic necroptosis in goslings.Vet Q202642677992PubTator, text miningPubMed
Deciphering HPV-Associated Immune Evasion in Cervical Cancer Through Multi-Omics Profiling and Computational Screening.Anal Cell Pathol (Amst)202642635083PubTator, text miningPubMed
Binding of death receptor 3 (DR3) to intracellular TRADD and TRAF2 is independent of its natural ligand, TL1A.J Immunol202642522260PubTator, text miningPubMed
Diosgenin inhibits necroptosis to alleviate NAFLD by blocking the RIPK1/RIPK3/MLKL pathway.J Nutr Biochem202642323101PubTator, text miningPubMed
Functional variants in ATF4 and PMAIP1 reveal mitochondrial apoptosis dependencies driving pancreatic cancer progression.Naunyn Schmiedebergs Arch Pharmacol202642024236PubTator, text miningPubMed
Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers.Cancer Innov202642016510PubTator, text miningPubMed
Gene Expression Alterations Associated With Resveratrol-Induced Antiproliferative Effects and S-Phase Cell Cycle Arrest in Osteosarcoma Cancer Cells.J Cell Mol Med202641937498PubTator, text miningPubMed
Role of aging‑related cytokines in neurodegenerative disease (Review).Int J Mol Med202641930561PubTator, text miningPubMed
Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome.Nature202641922760Swiss-Prot, curatedPubMed

1 to 10 of 2,847

See all 2,847 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8717

GET https://conductscience.org/api/genes/v1/8717/patents?page=2