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Gene · 8720

MBTPS1: membrane bound transcription factor peptidase, site 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MBTPS1: membrane bound transcription factor peptidase, site 1. Genes, record 8720. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8720

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Gene

Symbol
MBTPS1
HGNC
Name
membrane bound transcription factor peptidase, site 1
HGNC
NCBI Gene ID
8720
NCBI Gene
HGNC ID
HGNC:15456
HGNC
Ensembl
ENSG00000140943
NCBI Gene
Aliases
CAOP, KIAA0091, PCSK8, S1P, SEDKF, SKI-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14703Membrane-bound transcription factor site-1 protease1,0523Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11575Q14703Espacenet
JP 2026004568 A2026-01-1453214Q14703Espacenet
EP 4650780 A22025-11-196875Q14703Espacenet
EP 4641201 A22025-10-296700Q14703Espacenet
JP 2025529142 A2025-09-042566Q14703Espacenet
US 12371689 B22025-07-292566Q14703Espacenet
JP 2025517969 A2025-06-126700Q14703Espacenet
JP 2025517970 A2025-06-126875Q14703Espacenet
JP 2025013347 A2025-01-24575Q14703Espacenet
EP 4406585 A22024-07-31575Q14703Espacenet

1 to 10 of 58

See all 58 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,074

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMBTPS1 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy112025
P30CA008748Cancer Center Support Grant102025
P30CA016059Massey Cancer Center - Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant82025
UL1TR001863Yale Clinical and Translational Science Award72025
P30DK056341Washington University Nutrition Obesity Research Center52025
P50AA011999Southern California Research Center for ALPD and Cirrhosis52025
P30CA016087Cancer Center Support Grant42025
P30DK020579Diabetes Research Center42025
R00GM141261The mechanistic basis for targeted protein degradation in lipid metabolism42025

1 to 10 of 2,074Source NIH's project files

See all 2,074 nih grants

Papers2,858

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Endothelial Collapse as a Convergent Immunovascular Phenotype in Sepsis and Severe Arboviral Disease: The SIMVAC Model.Pathogens202642796720PubTator, text miningPubMed
Combined Modulation of Ceramide and S1P Pathways Induces Strong Cytotoxicity in SH-SY5Y Neuroblastoma Cells.Int J Mol Sci202642794556PubTator, text miningPubMed
Sphingolipid Remodeling in Colorectal Cancer Reveals a Continuum-like Metabolic Organization.Antioxidants (Basel)202642792175PubTator, text miningPubMed
Hyaluronidase-enhanced delivery in gene therapy and regenerative medicine for improved vector, cell, and cargo access.Front Drug Deliv202642756066PubTator, text miningPubMed
C/EBPδ regulates SPHK1-dependent excessive autophagy in decidualization defects of chronic endometritis.Reproduction202642704675PubTator, text miningPubMed
Roles of Ceramide Glucosyltransferase in Controlling Cerebral Microvascular Endothelial Integrity and Angiogenesis Post-Ischemia/Reperfusion.Transl Stroke Res202642625084PubTator, text miningPubMed
Therapeutic targeting of G protein-coupled receptors in central nervous system disorders: from novel mechanisms to precision pharmacology.Eur J Pharmacol202642624449PubTator, text miningPubMed
Erratum: Macrophage polarization involved the inflammation of chronic obstructive pulmonary disease by S1P/HDAC1 signaling.Am J Cancer Res202642597431PubTator, text miningPubMed
Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circ Res202642594169PubTator, text miningPubMed
Liver reprogramming toward hepatocellular carcinoma following hepatitis C sustained virologic response: a narrative review.Transl Gastroenterol Hepatol202642592470PubTator, text miningPubMed

1 to 10 of 2,858

See all 2,858 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8720

GET https://conductscience.org/api/genes/v1/8720/patents?page=2