Gene · 8720
MBTPS1: membrane bound transcription factor peptidase, site 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MBTPS1: membrane bound transcription factor peptidase, site 1. Genes, record 8720. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8720
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14703 | Membrane-bound transcription factor site-1 protease | 1,052 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents58
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4705273 A2 | 2026-03-11 | 575 | Q14703 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 53214 | Q14703 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6875 | Q14703 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6700 | Q14703 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2566 | Q14703 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2566 | Q14703 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6700 | Q14703 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6875 | Q14703 | Espacenet |
| JP 2025013347 A | 2025-01-24 | 575 | Q14703 | Espacenet |
| EP 4406585 A2 | 2024-07-31 | 575 | Q14703 | Espacenet |
1 to 10 of 58
See all 58 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,074
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MBTPS1 papers | Newest fiscal year |
|---|---|---|---|
| P01CA097132 | Sphingolipids in Cancer Biology and Therapy | 11 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 7 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 5 | 2025 |
| P50AA011999 | Southern California Research Center for ALPD and Cirrhosis | 5 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 4 | 2025 |
| P30DK020579 | Diabetes Research Center | 4 | 2025 |
| R00GM141261 | The mechanistic basis for targeted protein degradation in lipid metabolism | 4 | 2025 |
1 to 10 of 2,074Source NIH's project files
See all 2,074 nih grantsPapers2,858
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Endothelial Collapse as a Convergent Immunovascular Phenotype in Sepsis and Severe Arboviral Disease: The SIMVAC Model. | Pathogens | 2026 | 42796720 | PubTator, text mining | PubMed |
| Combined Modulation of Ceramide and S1P Pathways Induces Strong Cytotoxicity in SH-SY5Y Neuroblastoma Cells. | Int J Mol Sci | 2026 | 42794556 | PubTator, text mining | PubMed |
| Sphingolipid Remodeling in Colorectal Cancer Reveals a Continuum-like Metabolic Organization. | Antioxidants (Basel) | 2026 | 42792175 | PubTator, text mining | PubMed |
| Hyaluronidase-enhanced delivery in gene therapy and regenerative medicine for improved vector, cell, and cargo access. | Front Drug Deliv | 2026 | 42756066 | PubTator, text mining | PubMed |
| C/EBPδ regulates SPHK1-dependent excessive autophagy in decidualization defects of chronic endometritis. | Reproduction | 2026 | 42704675 | PubTator, text mining | PubMed |
| Roles of Ceramide Glucosyltransferase in Controlling Cerebral Microvascular Endothelial Integrity and Angiogenesis Post-Ischemia/Reperfusion. | Transl Stroke Res | 2026 | 42625084 | PubTator, text mining | PubMed |
| Therapeutic targeting of G protein-coupled receptors in central nervous system disorders: from novel mechanisms to precision pharmacology. | Eur J Pharmacol | 2026 | 42624449 | PubTator, text mining | PubMed |
| Erratum: Macrophage polarization involved the inflammation of chronic obstructive pulmonary disease by S1P/HDAC1 signaling. | Am J Cancer Res | 2026 | 42597431 | PubTator, text mining | PubMed |
| Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation. | Circ Res | 2026 | 42594169 | PubTator, text mining | PubMed |
| Liver reprogramming toward hepatocellular carcinoma following hepatitis C sustained virologic response: a narrative review. | Transl Gastroenterol Hepatol | 2026 | 42592470 | PubTator, text mining | PubMed |
1 to 10 of 2,858
See all 2,858 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8720
GET https://conductscience.org/api/genes/v1/8720/patents?page=2