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Gene · 8726

EED: embryonic ectoderm development

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EED: embryonic ectoderm development. Genes, record 8726. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8726

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Gene

Symbol
EED
HGNC
Name
embryonic ectoderm development
HGNC
NCBI Gene ID
8726
NCBI Gene
HGNC ID
HGNC:3188
HGNC
Ensembl
ENSG00000074266
NCBI Gene
Aliases
COGIS, HEED, WAIT-1, WAIT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75530Polycomb protein EED44181Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4828973 A22026-10-2854O75530Espacenet
EP 4805378 A12026-09-16566O75530Espacenet
JP 2026523341 A2026-07-141025O75530Espacenet
EP 4771137 A12026-07-08563O75530Espacenet
EP 4771157 A12026-07-08563O75530Espacenet
US 12649003 B22026-06-091025O75530Espacenet
JP 2026510339 A2026-04-02563O75530Espacenet
EP 4713451 A22026-03-25563O75530Espacenet
EP 4713452 A22026-03-25563O75530Espacenet
US 12558437 B22026-02-241025O75530Espacenet

1 to 10 of 36

See all 36 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,528

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEED papersNewest fiscal year
P30CA008748Cancer Center Support Grant412025
P30CA016672Cancer Center Support Grant242025
P30CA016086Cancer Center Support Grant132025
P30CA016087Cancer Center Support Grant112025
P30CA021765Cancer Center Support Grant (CCSG)112025
P30CA006973Regional Oncology Research Center102025
P30CA016058Cancer Center Support Grant92025
R01CA097098Targeting the MUC1-C Oncoprotein in Triple-Negative Breast Cancer82025
R01CA199652Repression via Facultative Heterochromatin82025
P30CA023168Cancer Center Support Grant72025

1 to 10 of 2,528Source NIH's project files

See all 2,528 nih grants

Papers3,114

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Interrupted surveillance and delayed genetic evaluation in neurofibromatosis type 1 associated with advanced malignant peripheral nerve sheath tumor and breast cancer: A case report.Int Cancer Conf J202642781021PubTator, text miningPubMed
PRC2 loss in MPNST is accompanied by SWI/SNF complex rewiring and sensitization to SMARCA2/4 and BET inhibition in vivo.Mol Cell Proteomics202642759702PubTator, text miningPubMed
Polycomb scaffolding subunit EED supports the SCLC neuroendocrine identity and EGFR-mutant LUAD-to-SCLC transformation.J Clin Invest202642611544PubTator, text miningPubMed
Case Report: Recurrent malignant phyllodes tumor with malignant peripheral nerve sheath tumor-like differentiation and loss of H3K27me3/RB1 expression.Front Oncol202642582074PubTator, text miningPubMed
Oncogenic Ras drives EED degradation and PRC2 dysfunction to promote aggressive squamous cell carcinoma.Nat Commun202642443217PubTator, text miningPubMed
Polycomb protein embryonic ectoderm development supports UV-induced effector regulatory T-cell responses in cutaneous inflammation.J Invest Dermatol202642425363PubTator, text miningPubMed
Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.PLoS Genet202642371968PubTator, text miningPubMed
Identification and Prognostic Analysis of Immune-Related Genes Co-Regulated by Key Histone Modifications in Breast Cancer.Curr Issues Mol Biol202642353587PubTator, text miningPubMed
Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2-Selective Small Molecule Inhibitor.Adv Sci (Weinh)202642314051PubTator, text miningPubMed
EZH2 Serine 21 Phosphorylation Restrains Compact-State PRC2 Activation and H3K27me3 Propagation.bioRxiv202642282706PubTator, text miningPubMed

1 to 10 of 3,114

See all 3,114 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8726

GET https://conductscience.org/api/genes/v1/8726/patents?page=2