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Gene · 873

CBR1: carbonyl reductase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CBR1: carbonyl reductase 1. Genes, record 873. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/873

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Gene

Symbol
CBR1
HGNC
Name
carbonyl reductase 1
HGNC
NCBI Gene ID
873
NCBI Gene
HGNC ID
HGNC:1548
HGNC
Ensembl
ENSG00000159228
NCBI Gene
Aliases
CBR, PG-9-KR, SDR21C1, hCBR1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P16152Carbonyl reductase [NADPH] 12776Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440034P16152Espacenet
EP 4650780 A22025-11-193425P16152Espacenet
JP 2025517970 A2025-06-123425P16152Espacenet
JP 2025062604 A2025-04-1411760P16152Espacenet
US 11821020 B22023-11-211P16152Espacenet
US 11446398 B22022-09-2011760P16152Espacenet
JP 2022524081 A2022-04-27114731P16152Espacenet
JP 2022500063 A2022-01-041P16152Espacenet
US 11078247 B22021-08-031636P16152Espacenet
KR 1020210064292 A2021-06-021P16152Espacenet

1 to 10 of 42

See all 42 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,369

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCBR1 papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology212025
P30CA043703Case Comprehensive Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant72025
P30CA008748Cancer Center Support Grant62025
P30CA016056Roswell Park Cancer Center Support Grant52025
P30CA016520Abramson Cancer Center Support Grant42025
P30CA091842Cancer Center Support Grant42025
P40OD010440Caenorhabditis Genetics Center42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202832025

1 to 10 of 1,369Source NIH's project files

See all 1,369 nih grants

Papers2,488

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting prostaglandin catabolism via topical nanotherapy rescues vision in ischemic optic neuropathy.Neurotherapeutics202642748895PubTator, text miningPubMed
Addressing translational barriers in intra-articular drug delivery for cartilage regeneration.J Control Release202642716128PubTator, text miningPubMed
Carbonyl reductase 1: A redox-regulating carbonyl detoxification enzyme in health and disease.Chem Biol Interact202642674267PubTator, text miningPubMed
Artificial Intelligence- and Machine Learning-Assisted Structure-Based Virtual Screening of Compounds That Target 15PGDH.Pharmaceutics202642654074PubTator, text miningPubMed
Proteome-Wide Mendelian Randomization Identifies Causal Proteins for Multiple Sclerosis Susceptibility and Severity.Genes (Basel)202642510850PubTator, text miningPubMed
Inhibiting 15-PGDH restores redox homeostasis and confers neuroprotection in Parkinson's disease.Redox Biol202642398271PubTator, text miningPubMed
RNA polymerase inhibitors reveal active-site motions essential for the nucleotide addition cycle.Proc Natl Acad Sci U S A202642378287PubTator, text miningPubMed
Pachydermoperiostosis (Touraine-Solente-Gole syndrome): A case report and literature review.Medicine (Baltimore)202642332506PubTator, text miningPubMed
Genetic and health determinants of cancer risk in Bangladeshi and Pakistani individuals in the UK.Nat Commun202642315506PubTator, text miningPubMed
Integrative machine learning and network toxicology framework for assessing environmental pollutant TCDD-induced osteoarthritis risk: a computational cheminformatics approach.Front Pharmacol202642292825PubTator, text miningPubMed

1 to 10 of 2,488

See all 2,488 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/873

GET https://conductscience.org/api/genes/v1/873/patents?page=2